Test Price
2,800 AED✅ Home Collection Available
ANO5 Gene Gnathodiaphyseal Dysplasia Genetic Test | 2800 AED | DNA Labs UAE
Executive Summary & Core Metrics
- Diagnostic Accuracy: 99.9% sensitivity via ISO-certified next-generation sequencing (NGS) for full-gene analysis including deep intronic regions.
- Premium Logistics: VIP mobile phlebotomy & temperature-controlled cold-chain home collection available daily 8 AM – 11 PM.
- Clinical Guidance: Complimentary telephonic consultation post-test to interpret results with a board‑certified medical geneticist.
- Insurance Support: Direct billing verification via WhatsApp at +971 54 548 8731; seamless pre‑approval assistance for UAE insurers.
Test Overview & Methodology
Comprehensive ANO5 Gene Sequencing
The ANO5 Genetic Test employs next‑generation sequencing (NGS) to detect single‑nucleotide variants, insertions/deletions, and copy‑number variations in the ANO5 gene. This test provides a definitive molecular diagnosis for gnathodiaphyseal dysplasia (GDD), a rare autosomal‑dominant skeletal‑dental disorder characterised by jaw swelling, long‑bone fragility, and cemento‑osseous lesions. It is indicated for individuals with compatible clinical features, a family history of GDD, or inconclusive radiographic findings.
| Feature | Our Test (NGS) | Closest Alternative (Sanger) |
|---|---|---|
| Methodology | Full‑gene Next‑Generation Sequencing – detects point mutations, indels, CNVs | Sanger sequencing – limited to pre‑defined exons, lower resolution |
| Diagnostic Sensitivity | >99% (including deep intronic variants) | ~95% (misses large rearrangements) |
| Turnaround Time | 3–4 weeks (ISO‑certified cold‑chain logistics) | 4–6 weeks (often requires multiple runs) |
Physician Insight & Safety Protocols
“As a consultant in medical genetics, I emphasize that a positive ANO5 mutation result must always be correlated with clinical and radiographic findings. This test provides a powerful diagnostic anchor, but it does not replace a thorough physical examination, family pedigree analysis, and multidisciplinary evaluation. I urge every patient to involve their treating physician in result interpretation and follow‑up care.”
– Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Pre‑Test Advisory
- A detailed clinical history focusing on jaw, dental, or long‑bone symptoms is required before sample collection.
- Mandatory genetic counselling session to construct a pedigree chart of affected family members ensures accurate variant classification.
- No dietary or drug restrictions are necessary; continue all prescribed medications unless your physician advises otherwise.
Safety Exclusions & Red Flags
- Minors: Genetic testing on individuals under 18 requires documented parental consent and certified genetic counselling as per UAE regulations.
- Acute Symptoms: Sudden jaw swelling, vision changes, severe bone pain, or breathing difficulty warrant immediate emergency care; do not rely on elective genetic testing.
- Pregnancy/Lactation: The test is safe, but result interpretation during pregnancy requires specialised prenatal consultation.
Patient FAQ & Clinical Guidance
1. What is the ANO5 Genetic Test?
The ANO5 NGS test sequences the entire ANO5 gene to identify disease‑causing mutations for gnathodiaphyseal dysplasia. It analyses all coding regions and adjacent intronic boundaries using next‑generation sequencing, delivering a definitive molecular diagnosis that can guide management by clinical geneticists, orthopaedic surgeons, and dentists.
2. How should I prepare for the ANO5 genetic test?
You must attend a genetic counselling session to draw a pedigree chart of affected relatives. This step is mandatory and ensures accurate variant interpretation. Our team will collect a blood sample via painless home collection with VIP mobile phlebotomy, and we provide all necessary clinical history forms beforehand. No fasting is required.
3. Is the test covered by insurance in the UAE?
We offer direct billing verification via WhatsApp at +971 54 548 8731 for UAE insurers. After you provide your policy details, our team confirms coverage within hours. We work with all major UAE networks and assist with pre‑approvals where required. Co‑payments or the full cost (2800 AED) can be settled via secure online payment.
UAE Regulatory & Data Privacy Adherence
Data Protection & Health Information Governance
All patient data and genetic results are handled in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical testing safety and patient consent follow Federal Decree-Law No. 4 of 2016 on Medical Liability. DNA Labs UAE maintains ISO‑certified processes and strict confidentiality protocols for all genetic data.
Clinical & Logistical Metadata
| Test Name | ANO5 Gene Gnathodiaphyseal Dysplasia Genetic Test (NGS) |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral whole blood (3–5 mL in EDTA tube) – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily 8 AM – 11 PM |
| Methodology Used | Next‑Generation Sequencing (NGS) – full gene sequencing with CNV detection |
| ICD-10-CM Code | M85.8 (Other specified disorders of bone density and structure), Z13.89 (Encounter for screening for other genetic diseases) |
| LOINC Code | 82293-6 (ANOS1 gene mutation analysis in Blood by NGS) |
| DHA Facility License & Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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