Test Price
2,800 AEDโ Home Collection Available
ALPL Gene Hypophosphatasia (Adult) Genetic Test in UAE | 2800 AED | DHA Certified
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by a DHA-licensed specialist.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The ALPL gene NGS (Next Generation Sequencing) test provides a definitive molecular diagnosis of adult hypophosphatasia, enabling targeted management by specialists such as Endocrinologists, Clinical Geneticists, and Rheumatologists. Full gene sequencing and deletion/duplication analysis ensures detection of novel or rare mutations.
Our Test vs. Closest Alternative
| Feature | Our ALPL NGS Test | Competitor Standard |
|---|---|---|
| Methodology | Full gene NGS + deletion/duplication analysis (LC-MS/MS validated) | Targeted mutation panel or Sanger sequencing only |
| Diagnostic Precision | 99.9% sensitivity, detects novel variants | 80โ90% sensitivity, limited variant coverage |
| Turnaround Time | 3 to 4 Weeks | 4 to 6 Weeks |
| Pre-test Counselling | Included genetic counselling session & pedigree charting | Often not included |
| Sample Options | Whole Blood, Extracted DNA, or Dried Blood Spot (FTA Card) | Whole Blood only |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh (Consultant Medical Genetics, DHA: 9294403) โ โWaiting for genetic test results can be distressing. This analysis provides vital molecular clarity but must always be interpreted alongside biochemical markers, imaging, and the complete clinical picture. Do not alter any prescribed therapy until you have discussed the findings with your managing physician.โ
Advisory Notice
โ Do not discontinue or adjust any prescribed medications without consulting your doctor. The test result alone should not be used for treatment decisions.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Recent blood transfusion (within 2 weeks) may compromise DNA integrity โ reschedule accordingly.
- Exclusion: Inability to provide informed consent or, for minors, absence of legal guardian consent as per Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Red Flag: Sudden severe bone pain, atraumatic fractures, or symptoms of hypercalcemia (confusion, vomiting, excessive thirst) โ seek emergency medical attention immediately.
- Red Flag: Any signs of respiratory distress or seizures โ contact emergency services.
Patient FAQ & Clinical Guidance
1. What does the ALPL gene test detect, and how will it help?
The ALPL NGS test identifies mutations causing adult hypophosphatasia, providing accurate diagnosis and guiding personalized treatment and monitoring. This comprehensive DNA analysis scans the entire gene to detect rare or novel mutations associated with low alkaline phosphatase activity. A positive result helps your Endocrinologist or Geneticist plan enzyme replacement, manage bone health, and screen at-risk family members. Genetic counselling is provided before and after the test.
2. How should I prepare and what is the sample collection process?
No fasting is required. You may provide a blood sample, extracted DNA, or a finger-prick dried blood spot on an FTA card. Our VIP home collection team arrives with temperature-controlled cold-chain equipment for whole blood or DNA samples. The entire process complies with UAE PDPL privacy regulations, and samples are processed under ISO 9001:2015 certified protocols. A pre-test genetic counselling session is included to document family pedigree.
3. How long do results take and who will interpret them?
Results are ready in 3 to 4 weeks from sample receipt. A detailed report includes identified variants, clinical significance, and ICD-10 codes. A DHA-licensed physician provides a telephonic clinical interpretation and coordinates with your referring doctor. Direct insurance billing verification is available via WhatsApp.
UAE Regulatory & Data Privacy Adherence
This test is fully compliant with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Your personal health data is encrypted, stored securely, and accessed only by authorized personnel for clinical interpretation. The laboratory holds ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | ALPL Gene Hypophosphatasia (Adult) Genetic Test (NGS + Deletion/Duplication) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA, or Dried Blood Spot (FTA Card) |
| Methodology Used | Next Generation Sequencing (NGS) with deletion/duplication analysis, validated by LC-MS/MS |
| ICD-10-CM Code | E83.30, Z15.09 |
| LOINC Code | 81239-4 |
| DHA Facility License & Laboratory Address | DHA Facility License No: 1143 Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE Corporate Lab: DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians