Test Price
2,800 AED✅ Home Collection Available
AK2 Gene Reticular Dysgenesis Genetic Test in UAE
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139) at DNA Labs UAE.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM) for standard blood samples.
- Clinical Guidance: Comprehensive pre- and post-test genetic counselling by DHA-licensed Consultant Medical Genetics (DHA ID: 9294403).
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
- Regulatory Compliance: DHA Facility License 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE.
Test Overview & Methodology
The AK2 Gene Reticular Dysgenesis Genetic Test employs Next-Generation Sequencing (NGS) to analyze the entire coding region and splice-site junctions of the AK2 gene. This assay provides a definitive molecular diagnosis for severe combined immunodeficiency (SCID) caused by biallelic pathogenic variants, enabling precise therapeutic planning and cascade screening for at-risk family members.
| Feature | Our Test (AK2 NGS) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Precision | 99.9% analytical sensitivity & specificity; covers full coding region ± 20 bp intronic boundaries with >100× read depth | 99.9% for targeted region only; limited to known hotspot mutations |
| Method | Next‑Generation Sequencing (NGS) – Illumina platform, high-throughput parallel sequencing | Sanger Sequencing – low-throughput, single amplicon processing |
| Turnaround Time | 3–4 Weeks (expedited processing available upon request) | 6–8 Weeks for full gene analysis (multiple fragments) |
Physician Insight & Safety Protocols
"As a Consultant Medical Genetics specializing in inherited immunodeficiency disorders, I confirm that the AK2 gene NGS test is the gold standard for diagnosing reticular dysgenesis. The high coverage and read depth of this assay ensure comprehensive detection of pathogenic variants. It is imperative that results are interpreted alongside clinical findings and immunological phenotyping. Pre- and post-test genetic counselling is essential for patient understanding and family planning."
– Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Medication and Clinical Advisory
Do not discontinue prescribed medication without consulting your doctor. Immunosuppressive therapy, immunoglobulin replacement, or antimicrobial prophylaxis must be maintained as directed by your treating physician. Abrupt cessation could trigger life-threatening infections or autoimmune complications.
Exclusion Criteria and Emergency Red Flags
- Acute febrile illness or uncontrolled infection at time of blood draw – reschedule.
- Recently transfused (< 2 weeks) – may cause sample contamination; notify lab prior to collection.
- Emergency signs requiring immediate hospital visit: severe respiratory distress, high fever unresponsive to antipyretics, or signs of septic shock.
- Minors must have legal guardian consent per Federal Decree-Law No. 4 of 2016 on Medical Liability.
Patient FAQ & Clinical Guidance
1. What is the clinical utility of the AK2 gene test for reticular dysgenesis?
This test definitively confirms reticular dysgenesis by detecting biallelic pathogenic variants in the AK2 gene. It enables targeted treatment planning, including urgent hematopoietic stem cell transplantation evaluation, and allows for accurate recurrence risk counselling and family cascade screening.
2. How is the sample collected and what are the pre-test requirements?
A mandatory pre-test genetic counselling session is required to construct a three-generation pedigree and obtain informed consent. A standard peripheral blood sample (EDTA tube) or DNA FTA card is collected by our certified phlebotomists via VIP Mobile Phlebotomy or at our Dubai Healthcare City facility.
3. What is the turnaround time for this genetic test?
The standard turnaround time is 3–4 weeks from sample receipt in the laboratory. An expedited processing option is available for urgent clinical cases upon physician request.
4. Is this test covered by insurance in the UAE?
We verify direct billing with major UAE insurers. Please contact our billing team via WhatsApp at +971 54 548 8731 to confirm your specific policy coverage for genetic testing.
5. How does next-generation sequencing benefit the diagnosis of SCID?
NGS allows simultaneous analysis of multiple genes associated with severe combined immunodeficiency, including AK2, with high sensitivity and specificity. It can detect novel variants, copy number variations, and deep intronic mutations that might be missed by traditional sequencing methods, providing a comprehensive molecular diagnosis.
UAE Regulatory & Data Privacy Adherence
Trust & Compliance Framework
DNA Labs UAE strictly adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genomic data is encrypted, securely stored, and processed exclusively within the UAE. Results are released only to the ordering physician and patient with explicit written consent. We are fully compliant with DHA facility licensing standards and international laboratory quality management systems.
Clinical & Logistical Metadata
| Test Name | AK2 Gene Reticular Dysgenesis Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA) or DNA FTA Card |
| Methodology Used | Next‑Generation Sequencing (NGS) – Illumina Platform, >100× read depth |
| ICD-10-CM Code | D81.0 |
| LOINC Code | 101371-1 |
| DHA Facility License & Laboratory Address | DHA License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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