Test Price
2,800 AED✅ Home Collection Available
AIFM1 Gene Combined Oxidative Phosphorylation Deficiency Type 6 Genetic Test
Executive Summary & Core Metrics
Test Summary
The AIFM1 genetic test utilizes Next-Generation Sequencing (NGS) to diagnose combined oxidative phosphorylation deficiency type 6 with a guaranteed diagnostic accuracy of >99.9%. The test is performed at an ISO 9001:2015 accredited laboratory (Certificate: INT/EGQ/2509DA/3139) under the clinical oversight of Consultant Medical Genetics, Ms. Lina Osama Zaki Quteineh (DHA Registration ID: 9294403). VIP Mobile Phlebotomy and temperature-controlled cold-chain home collection is available daily from 8 AM to 11 PM. Direct billing verification via WhatsApp +971 54 548 8731. Strict adherence to UAE data protection laws.
Test Overview & Methodology
The AIFM1 gene encodes apoptosis-inducing factor, a mitochondrial protein essential for oxidative phosphorylation and energy production. Pathogenic mutations cause severe combined oxidative phosphorylation deficiency type 6, marked by neonatal encephalomyopathy, cardiomyopathy, and lactic acidosis. This NGS-based genetic test sequences the entire coding region and flanking intronic sequences of AIFM1 with >99.9% analytical sensitivity to detect pathogenic single-nucleotide variants, indels, and copy number variations, enabling definitive molecular diagnosis and informed family planning.
Why Choose Our AIFM1 NGS Test?
| Feature | Our AIFM1 NGS Test | Single-Gene Sanger Sequencing |
|---|---|---|
| Methodology | Next-Generation Sequencing (Illumina platform) | Sanger sequencing (exon-by-exon) |
| Gene Coverage | Complete coding region + flanking intronic sequences, CNV detection | Selected exons only; CNVs often missed |
| Turnaround Time | 3 – 4 weeks | 6 – 8 weeks |
| Analytical Sensitivity | >99.9% (validated per ISO 9001:2015) | ~99% (limited to targeted region) |
| Price (AED) | 2,800 | 1,800 |
Physician Insight & Safety Protocols
"I recognize the emotional burden of pursuing a genetic diagnosis for a suspected mitochondrial disorder. This test can provide critical molecular confirmation, but a negative result does not exclude other genetic or metabolic conditions—integrated clinical assessment by a pediatric neurologist or medical geneticist is vital. Please never alter any treatment based solely on this lab report; always review findings with your supervising physician."
– Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory
⚠️ Important Medication Warning
Do not discontinue any prescribed medication without consulting your doctor. This test does not provide therapeutic recommendations.
Safety & Eligibility Criteria
Exclusion Criteria
- This test is not suitable for completely asymptomatic individuals without a clinical indication or positive family history of mitochondrial disease; recreational genomics exploration is not supported.
- Minors must have legal guardian consent in compliance with UAE Federal Law No. 2 of 2019 concerning health information and communication technology.
Pre-Test Requirement
- A mandatory genetic counseling session to draw a pedigree chart of affected family members is provided; results are relayed only after this session.
Emergency Red Flags
- If the patient experiences new-onset seizures, acute encephalopathy, severe metabolic acidosis, or respiratory insufficiency, go to the nearest emergency department immediately—do not delay for test results.
Patient FAQ & Clinical Guidance
1. What does the AIFM1 gene test look for and how accurate is it?
The AIFM1 genetic test identifies pathogenic mutations in the AIFM1 gene linked to combined oxidative phosphorylation deficiency type 6 with >99.9% diagnostic sensitivity. Our NGS assay sequences the entire coding region and exon-intron boundaries to detect single nucleotide variants, small insertions/deletions, and copy number variations. It is validated on an ISO-accredited platform, and all clinically significant findings are confirmed by orthogonal methods before reporting.
2. How long do results take and what is the step-by-step process?
Results are typically available within 3 to 4 weeks after the laboratory receives your blood sample, following rigorous genomic analysis and biocurated interpretation. The process: schedule home collection via WhatsApp, a certified phlebotomist arrives (with cold-chain transport), sample is processed in our ISO-lab, data analysis is completed, and a post-test clinical guidance call is arranged to explain results in plain language.
3. Is this genetic test covered under UAE health insurance plans?
We offer direct billing verification via WhatsApp at +971 54 548 8731; many UAE insurers cover medically necessary genetic testing for suspected mitochondrial disorders. Coverage depends on your policy and eligibility for genetic diagnostics—typically required pre‑authorization from a specialist (General Physician, Pediatric Neurologist, or Medical Geneticist). Our team assists in obtaining approvals and can provide an itemized invoice for reimbursement if needed.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance
This test is conducted under the regulatory framework of the Dubai Health Authority (DHA) and in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient data is encrypted, access-controlled, and processed solely for diagnostic purposes with explicit consent. Clinical safety and patient consent adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | AIFM1 Gene Combined Oxidative Phosphorylation Deficiency Type 6 Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3 – 4 weeks |
| Sample Type / Matrix | Whole Blood (Peripheral) – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection |
| Methodology Used | Next-Generation Sequencing (NGS) – Illumina platform, targeted gene panel with full coverage |
| ICD-10-CM Code | E88.4 |
| LOINC Code | 92762-7 |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE Corporate Lab Branding: DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians