Test Price
2,800 AEDโ Home Collection Available
ADAM10 Gene Sequencing for Reticulate Acropigmentation of Kitamura (RAK) in UAE | 2800 AED
Executive Summary & Core Metrics
Test Overview & Methodology
The ADAM10 Gene Analysis utilises Next-Generation Sequencing (NGS) to detect pathogenic variants in the ADAM10 gene, confirming a diagnosis of Reticulate Acropigmentation of Kitamura (RAK), a rare autosomal dominant pigmentary disorder. This molecular diagnostic approach delivers definitive genetic confirmation, enabling targeted family screening and informed clinical management.
| Feature | Our Test โ Precision NGS | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Diagnostic Precision | 99.9% analytical sensitivity; full gene coverage (exons, splice sites, deep intronic regions) | 95โ98% sensitivity; limited to exonic regions, may miss deep intronic variants |
| Methodology | Next-Generation Sequencing (NGS) โ massive parallel sequencing | Sanger sequencing โ single amplicon analysis |
| Turnaround Time | 3โ4 weeks | 6โ8 weeks for full gene coverage |
| Sample and Logistics | Simple blood draw; ISO cold-chain home collection included | Blood draw; often requires hospital visit |
Physician Insight & Safety Protocols
โThe ADAM10 gene analysis is a highly specific molecular tool for confirming reticulate acropigmentation of Kitamura. However, clinical correlation with dermatoscopic findings and detailed pedigree assessment remains essential. A negative sequencing result does not exclude other genetic pigmentary disorders presenting with similar reticulate patterns. Test outcomes must always be interpreted by a qualified clinical geneticist. Patients should continue all current prescribed treatments and must never discontinue any medication without direct consultation with their treating physician.โ
Lina Osama Zaki Quteineh Consultant Medical Genetics | DHA Registration ID: 9294403
Medication Advisory
Medication Advisory:
Do not discontinue prescribed medication without consulting your doctor. This test does not replace clinical evaluation.
Exclusion Criteria and Emergency Red Flags
- Do not undergo blood collection if you have an active skin infection or cellulitis at the venepuncture site.
- Recent blood transfusion (within 4 weeks) may interfere with germline genetic analysis; please inform the phlebotomist.
- Emergency Red Flags: If you experience sudden, widespread skin blistering, severe photosensitivity, or signs of systemic illness such as fever, joint pain, or neurological symptoms, seek immediate medical attention. These manifestations are not typical of isolated RAK and require urgent evaluation.
Patient FAQ & Clinical Guidance
1. What is Reticulate Acropigmentation of Kitamura (RAK)?
Reticulate Acropigmentation of Kitamura is a rare genetic skin condition characterised by a network-like pattern of hyperpigmentation typically beginning in adolescence. It follows an autosomal dominant inheritance pattern and is caused by pathogenic variants in the ADAM10 gene.
2. How is the ADAM10 gene test performed?
The test requires a simple blood sample collected through our ISO-certified VIP home phlebotomy service, then analysed by Next-Generation Sequencing of the entire ADAM10 gene including coding exons, splice sites, and deep intronic regions.
3. How will I receive my results and understand them?
Results are delivered in a secure digital report within 3 to 4 weeks, followed by a mandatory post-test genetic counselling session to interpret findings, discuss implications for family members, and guide clinical management.
4. Who should consider this genetic test?
This test is indicated for individuals with clinical features consistent with reticulate acropigmentation of Kitamura, including progressive reticulate hyperpigmentation on the dorsa of hands and feet that may extend to proximal limbs. It is also appropriate for at-risk family members of a confirmed case.
UAE Regulatory & Data Privacy Adherence
UAE Regulatory Compliance
This service complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical testing, patient consent, and safety protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. All genetic data is handled with strict confidentiality and is not disclosed to third parties without explicit patient consent as required by UAE law.
Clinical & Logistical Metadata
| Test Name | ADAM10 Gene Sequencing for Reticulate Acropigmentation of Kitamura (RAK) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 weeks |
| Sample Type / Matrix | Peripheral whole blood collected via VIP Mobile Phlebotomy and Temperature-Controlled Cold-Chain Home Collection (available daily from 8 AM to 11 PM) |
| Methodology Used | Next-Generation Sequencing (NGS) with full gene coverage including exons, splice sites, and deep intronic regions |
| ICD-10-CM Code | L81.8 |
| LOINC Code | 21636-6 |
| DHA Facility License and Laboratory Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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