Test Price
2,800 AED✅ Home Collection Available
ACTA2 Gene Multisystemic Smooth Muscle Dysfunction Syndrome Genetic Test in UAE | 2800 AED | DHA Guidelines
Executive Summary & Core Metrics
- ✓ Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.
- ✓ Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- ✓ Clinical Guidance: Complimentary Telephonic Post-Test Clinical Interpretation by a DHA-Licensed Consultant Medical Genetics.
- ✓ Insurance: Direct Billing Verification & Pre‑Authorization via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This definitive NGS test sequences the entire coding region of the ACTA2 gene to identify pathogenic variants responsible for multisystemic smooth muscle dysfunction syndrome (MSMDS), a hereditary disorder affecting vascular, ocular, and cerebrovascular smooth muscle. It is the gold‑standard for confirming clinical suspicion, guiding surveillance protocols, and enabling family cascade screening.
| Feature | Our ACTA2 NGS Test | Closest Alternative |
|---|---|---|
| Diagnostic Precision | Full‑gene NGS with 99.9% sensitivity | Single‑variant PCR, < 30% mutation coverage |
| Methodology | Next‑Generation Sequencing (Illumina® platform) | Sanger sequencing, limited to known hotspots |
| Turnaround Time | 3–4 Weeks (expedited options available) | 4–6 Weeks or longer |
| Clinical Support | Post‑test DHA Consultant Medical Genetics tele‑consultation | Generic lab report without specialist review |
| Price | 2800 AED | Varies (often >3500 AED without interpretation) |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh (DHA License: 9294403, Consultant Medical Genetics) emphasizes: “This test provides high-resolution genotype data, but a positive result must always be correlated with clinical phenotype and imaging findings. Never alter or discontinue prescribed medications without direct medical advice; genetic diagnosis does not replace ongoing specialist care.”
Important Advisory – Medication Continuity
Do not discontinue any prescribed medication without direct consultation with your treating physician. A genetic test result does not replace ongoing clinical management or specialist oversight.
Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Active bleeding disorder, inability to provide informed consent, acute febrile illness, or recent blood transfusion (within 2 weeks).
- Emergency Red Flags: If you experience sudden severe headache, vision loss, chest pain radiating to the back, or stroke‑like symptoms, seek immediate emergency care. These may indicate aortic aneurysm rupture or moyamoya‑related ischemia.
Patient FAQ & Clinical Guidance
1. What exactly does the ACTA2 genetic test detect?
The ACTA2 Genetic Test sequences the entire ACTA2 gene to detect pathogenic variants causing multisystemic smooth muscle dysfunction syndrome with 99.9% sensitivity. It identifies missense, nonsense, splice‑site, and small insertion/deletion mutations linked to thoracic aortic aneurysm, moyamoya disease, congenital mydriasis, and patent ductus arteriosus. Results guide personalized surveillance and early intervention.
2. Who should consider this test – is it only for children or also adults?
This test is indicated for individuals of any age with clinical features suggestive of MSMDS, family history of ACTA2‑related disease, or unexplained thoracic aortic aneurysm/stroke in young adults. Minors require legal guardian consent and mandatory pre‑genetic counseling in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability. Adults can self‑refer, but a referral from a medical geneticist or neurologist optimizes testing appropriateness.
3. How long does it take and how will I receive my results confidentially?
Turnaround time is 3 to 4 weeks post sample collection; results are delivered through a secure, encrypted patient portal compliant with UAE Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. A DHA‑licensed Consultant Medical Genetics will schedule a tele‑consult to walk you through the findings and recommended next steps.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates under DHA Facility License Number 1143 and adheres to the strictest data protection standards. All genetic data is handled in compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient consent is obtained per Federal Decree-Law No. 4 of 2016 on Medical Liability. Your privacy and confidentiality are paramount.
Clinical & Logistical Metadata
| Test Name | ACTA2 Gene Multisystemic Smooth Muscle Dysfunction Syndrome Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks (expedited options available) |
| Sample Type / Matrix | Peripheral Whole Blood (3–5 mL in EDTA tube) |
| Methodology Used | Next-Generation Sequencing (Illumina® platform), Full Gene Coding Region Analysis |
| ICD-10-CM Code | Q87.89 |
| LOINC Code | 21678-0 |
| DHA Facility License & Address | License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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