Test Price
2,800 AED✅ Home Collection Available
ABCA3 Gene Surfactant Metabolism Dysfunction Type 3 Genetic Test in UAE – 2800 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 accredited processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy & temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Post-test telephonic consultation with our DHA-licensed genetic counselors for result interpretation.
- Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This advanced next-generation sequencing (NGS) test sequences the entire ABCA3 gene to detect pathogenic variants associated with Surfactant Metabolism Dysfunction Type 3, a rare but often fatal neonatal respiratory disorder. Early diagnosis empowers timely clinical intervention and family planning. The test utilizes Illumina NovaSeq technology to achieve 99.9% analytical sensitivity for single nucleotide variants (SNVs), insertions/deletions, and copy number variations across the full coding region and flanking intronic sequences.
| Feature | Our Test (ABCA3 NGS) | Closest Alternative |
|---|---|---|
| Methodology | Next-Generation Sequencing (Illumina NovaSeq) | PCR-based targeted mutation panel |
| Analytical Sensitivity | 99.9% for SNVs, indels, CNVs | ~95% (misses rare variants) |
| Turnaround Time | 3 – 4 Weeks | 1 – 2 Weeks (limited scope) |
| Coverage | Full coding region ± flanking intronic sequences | Pre-selected hotspot mutations only |
| Clinical Utility | Definitive diagnosis, carrier screening, prenatal planning | Preliminary screening, often requires reflex to NGS |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics with extensive experience in the UAE, I recognize the profound impact of genetic testing on neonatal care. The ABCA3 gene test provides definitive diagnosis for surfactant dysfunction, but results must be interpreted alongside clinical findings and managed by a multidisciplinary team. Do not delay urgent medical care while awaiting results.” — Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory: Pre-Test Genetic Counseling
In compliance with Federal Decree-Law No. 4 of 2016 on Medical Liability, all patients must undergo a mandatory genetic counseling session and a three-generation pedigree chart construction before sample collection. This session is arranged via our DHA-licensed genetic counselors (virtual or in-person).
Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Blood collection should not proceed if the patient has active hemolysis, recent blood transfusion (within 4 weeks), or is receiving extracorporeal membrane oxygenation (ECMO).
- Emergency Red Flags: If the infant exhibits severe respiratory distress with grunting, nasal flaring, cyanosis (blue skin), or apnea, seek emergency medical attention immediately. Genetic results do not replace urgent clinical judgment.
- Medication Caution: Do not discontinue prescribed oxygen therapy or surfactant replacement without consulting your physician.
Patient FAQ & Clinical Guidance
1. What is the ABCA3 gene test and why is it needed?
Snippet: Identifies ABCA3 gene mutations causing fatal neonatal lung disease via NGS for definitive genetic diagnosis.
The test deciphers the entire coding sequence of the ABCA3 gene, which is critical for surfactant production in the lungs. Mutations lead to Surfactant Metabolism Dysfunction Type 3, a leading cause of severe respiratory distress in term newborns. Results guide life-saving interventions such as lung transplantation candidacy and inform family genetic counseling.
2. How is the test performed and what is the turnaround time?
Snippet: Home blood draw by DHA-licensed phlebotomist, results in 3–4 weeks for comprehensive genetic analysis.
A single blood sample (2–5 mL in EDTA tube) is collected via our VIP mobile phlebotomy service, transported in cold-chain packaging to our ISO-certified lab. NGS sequencing, data analysis, and clinical interpretation take 3–4 weeks. A secure report is delivered through our patient portal, and a telephonic consultation is arranged to explain the findings.
3. Is genetic counseling required before testing?
Snippet: Yes, mandatory per Federal Decree-Law No. 4 of 2016 on Medical Liability. A counseling session and three-generation pedigree chart must precede testing.
In compliance with UAE law, all individuals undergoing genetic testing must first attend a certified genetic counseling session. We arrange a virtual or in-person session where a genetic counselor constructs a three-generation pedigree and explains the potential implications for the patient and family. The pedigree is a required part of your pre-test documentation.
4. What does the test cost and is insurance accepted?
Snippet: 2800 AED for the full gene sequencing, with direct billing for most UAE insurance plans.
The price is 2800 AED, including phlebotomy, genetic counseling, and the full laboratory analysis. We offer direct billing for many insurance providers; please contact us via WhatsApp at +971 54 548 8731 to verify your coverage.
5. How will I receive my results and what support is available?
Snippet: Results delivered via secure online portal with a follow-up telephonic consultation from your genetic counselor.
Once results are ready, you receive a secure link to download your comprehensive report. A DHA-licensed genetic counselor will then contact you for a telephonic session to explain findings, answer questions, and guide next steps for clinical management or family planning.
UAE Regulatory & Data Privacy Adherence
Data Protection: This service fully complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is processed with the highest confidentiality standards and stored on encrypted servers within the UAE.
Clinical Safety: Patient consent and clinical testing safety adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Pre-test genetic counseling is mandatory and conducted by DHA-licensed professionals.
Accreditation: ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139) – ensuring laboratory quality management and data integrity.
Clinical & Logistical Metadata
| Test Name | ABCA3 Gene Surfactant Metabolism Dysfunction Type 3 Genetic Test (NGS) |
| Price (AED) | 2,800 |
| Turnaround Time | 3 – 4 Weeks |
| Sample Type / Matrix | Peripheral whole blood (2–5 mL in EDTA tube) – VIP Mobile Phlebotomy & temperature-controlled cold-chain home collection available daily 8 AM–11 PM. |
| Methodology Used | Next-Generation Sequencing (Illumina NovaSeq) – full gene coding region ± flanking intronic sequences |
| ICD-10-CM Code | J84.81 (Other interstitial lung diseases with fibrosis in childhood – Surfactant metabolism dysfunction) |
| LOINC Code | 94251-2 (ABCA3 gene targeted mutation analysis in Blood or Tissue by Molecular genetics method) |
| DHA Facility License & Laboratory Address | DHA License: 1143 | DNA Labs UAE – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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