Test Price
1,600 AEDโ Home Collection Available
๐ Results in 1โ2 calendar days
PNH Comprehensive Workup (Flow Cytometry) โ FLAER, CD14, CD15, CD24, CD45, CD59, CD64, Glycophorin A in UAE
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 accredited flow cytometry processing at DNA Labs UAE.
- Premium Logistics: VIP mobile phlebotomy and temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM across Dubai and the UAE.
- Clinical Guidance: Complimentary telephonic post-test consultation to help you and your physician interpret clone size and clinical correlation.
- Insurance & Billing: Direct billing verification and insurance pre-approval support via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The PNH Comprehensive Workup is a high-sensitivity, 8-color flow cytometry assay that detects and quantifies glycosylphosphatidylinositol (GPI)โdeficient blood cells using the FLAER probe together with a curated panel of lineage-specific markers: CD14, CD15, CD24, CD45, CD59, CD64, and Glycophorin A. This test is the gold-standard method for diagnosing paroxysmal nocturnal hemoglobinuria (PNH), monitoring clone size over time, and guiding clinical decisions regarding anticoagulation, complement inhibition, or bone marrow transplantation.
| Feature | Our Test | Standard Alternative |
|---|---|---|
| Precision | FLAER-based detection of clones as low as 0.01% with full GPI-anchor deficiency profiling | Conventional CD55/CD59 only; may miss clones below 1% |
| Method | 8-color flow cytometry with immunophenotyping and lineage-specific gating | 2โ3 color basic panel |
| Turnaround Time | 1โ2 calendar days | 3โ5 working days |
Physician Insight & Safety Protocols
โThe PNH Comprehensive Workup provides a detailed map of GPI-anchor protein deficiency across granulocytes, monocytes, and red cells. Clone size must always be interpreted alongside hemoglobin, LDH, reticulocyte count, and thrombotic risk profile. Patients should continue all prescribed therapies and discuss results with their hematologist before making any treatment changes.โ
โ Mr. Prabhakar Reddy Kalathoor, Specialist Diagnostic Radiology | DHA Registration ID: 61713011
Medication Advisory
Do not alter or discontinue prescribed anticoagulants, steroids, or immunosuppressants without explicit instruction from your treating physician. Abrupt withdrawal may precipitate thromboembolic events, hemolytic crises, or bone marrow decompensation. Always carry your medication list to the phlebotomy appointment.
Exclusion Criteria & Emergency Red Flags
- Blood transfusion within the last 14 days (may dilute PNH clone and falsely reduce sensitivity).
- Severe neutropenia with absolute neutrophil count below 0.5 ร 10โน/L requiring urgent medical evaluation.
- Active uncontrolled infection or sepsis.
- Known anaphylactic reaction to phlebotomy or EDTA components.
Seek emergency care immediately if you experience:
- Sudden dark or cola-colored urine accompanied by abdominal or flank pain.
- Acute dyspnea, chest pain, or hemoptysis (possible pulmonary embolism).
- Severe headache, confusion, visual disturbances, or focal neurologic deficits (suggestive of cerebral thrombosis).
Patient FAQ & Clinical Guidance
1. What does the PNH Comprehensive Workup measure?
This test uses the FLAER probe and six cell-surface markers (CD14, CD15, CD24, CD45, CD59, CD64, Glycophorin A) to identify and quantify blood cells that lack GPI-anchored proteins. The result is reported as the percentage of PNH clones in granulocytes, monocytes, and red blood cells.
2. How should I prepare for the blood draw?
No fasting is required. A single 3 mL EDTA tube of peripheral blood is collected. Please inform the phlebotomist if you have received a blood transfusion within the past two weeks, as this may affect the accuracy of clone detection.
3. When will I receive my results and who interprets them?
Results are available within 1โ2 calendar days. The report includes the precise clone percentage for each cell lineage. A hematologist or the referring physician should correlate these findings with your clinical symptoms, LDH level, reticulocyte count, and thrombotic risk profile for accurate diagnosis and management.
4. Is home sample collection available for this test?
Yes. DNA Labs UAE offers VIP mobile phlebotomy and temperature-controlled cold-chain home collection daily from 8 AM to 11 PM. A trained phlebotomist will visit your home or office across Dubai and the UAE, ensuring proper sample handling and timely delivery to our ISO-accredited laboratory.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates under DHA Facility License No. 1143 and complies fully with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All patient data, test results, and clinical records are processed, stored, and transmitted using encrypted systems with strict access controls. Clinical laboratory operations adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring patient safety and informed consent protocols are maintained at every step.
Clinical & Logistical Metadata
| Test Name | PNH Comprehensive Workup (Flow Cytometry) โ FLAER, CD14, CD15, CD24, CD45, CD59, CD64, Glycophorin A |
| Price (AED) | 1,600 AED |
| Turnaround Time | 1โ2 calendar days |
| Sample Type / Matrix | Peripheral whole blood (3 mL EDTA tube). VIP mobile phlebotomy and temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM. |
| Methodology Used | 8-color flow cytometry with FLAER probe, CD14, CD15, CD24, CD45, CD59, CD64, Glycophorin A โ immunophenotyping with lineage-specific gating |
| ICD-10-CM Code | D59.5 (Paroxysmal Nocturnal Hemoglobinuria), D61.09 (Constitutional Aplastic Anemia), D64.9 (Anemia, Unspecified) |
| LOINC Code | 73592-1 (GPI-linked protein deficiency analysis [Presence] in Blood) |
| DHA Facility License & Laboratory Address | DHA Facility License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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Available in Arabic, English, Hindi & Urdu
Preparation Required
["No fasting is required.", "Inform the phlebotomist if you have received a blood transfusion within the past two weeks."]
Medically Reviewed by Dr. Dr. Prabhakar Reddy Kalathoor
All content reviewed by qualified professionals for accuracy.
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians