Test Price
1,600 AED✅ Home Collection Available
PNH Comprehensive Workup (Flow Cytometry) – FLAER, CD14, CD15, CD24, CD45, CD59, CD64, Glycophorin A in UAE | 1600 AED | 2026 DHA Guidelines
تحليل فحص PNH الشامل (قياس التدفق الخلوي) في الإمارات | 1600 درهم | إرشادات هيئة الصحة بدبي 2026
Executive Summary
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.
- Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection and VIP Mobile Phlebotomy.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
ضمان الدقة: حساسية تشخيصية بنسبة 99.9% عبر معالجة معتمدة من ISO. خدمات لوجستية متميزة: سحب منزلي بمعايير المستشفى ونقل مبرد معتمد. دعم طبي: استشارة هاتفية بعد الفحص لتفسير النتائج. تأمين: تحقق مباشر من التغطية عبر واتساب.
Overview
The PNH Comprehensive Workup is a high-sensitivity flow cytometry assay that detects and quantifies GPI‑deficient blood cells using the FLAER probe and a curated panel of lineage‑specific markers (CD14, CD15, CD24, CD45, CD59, CD64, Glycophorin A). This test is essential for diagnosing paroxysmal nocturnal hemoglobinuria, monitoring clone size, and guiding management of associated cytopenias or thrombosis. يقيس هذا الفحص خلايا الدم المصابة بعوز بروتينات GPI باستخدام تقنية FLAER وعلامات CD لتشخيص ومتابعة مرض الهيموغلوبينية الانتيابية الليلية.
| Feature | Our Test | Standard Alternative |
|---|---|---|
| Precision | FLAER‑based, detects clones as low as 0.01% with full GPI‑anchor deficiency | Conventional CD55/CD59 only; may miss clones <1% |
| Method | 8‑color flow cytometry with immunophenotyping and lineage gating | 2‑3 color basic panel |
| Speed (TAT) | 1–2 calendar days | 3–5 working days |
UAE Regulatory Compliance:
This service adheres to Federal Decree‑Law No. 41 of 2024 (Art. 87), the CDS Law 2026 (minors), and UAE PDPL (Data Privacy). All processing is performed under DHA‑approved clinical pathology license.
Medical Coding: ICD‑10‑CM D59.5 (Paroxysmal Nocturnal Hemoglobinuria), D61.09 (Constitutional Aplastic Anemia), D64.9 (Anemia, Unspecified); PIGA gene susceptibility marker. LOINC: 73592‑1 (GPI‑linked protein deficiency analysis [Presence] in Blood).
Physician Insight & Safety Protocol
“Dear Patient, the PNH Comprehensive Workup is a highly specialized diagnostic tool that identifies the absence of GPI‑anchored proteins on your blood cells. Results must be interpreted alongside your full clinical picture—particularly signs of hemolysis, thrombosis, or marrow failure. Please continue all prescribed therapies and discuss the findings with your attending physician.”
— Dr. PRABHAKAR REDDY (DHA License: 61713011)
Medication Warning
Do not discontinue prescribed medication without consulting your doctor. Abrupt withdrawal of anticoagulants, steroids, or immunosuppressants can precipitate serious complications.
Exclusion Criteria & Emergency Red Flags
- Recent blood transfusion within 14 days (may dilute PNH clone).
- Severe neutropenia (ANC <0.5 × 10⁹/L) requiring urgent medical management.
- Active uncontrolled infection or sepsis.
- Known history of anaphylaxis to phlebotomy components.
Seek Emergency Care if You Experience:
- Sudden dark‑colored urine with abdominal or back pain.
- Acute shortness of breath, chest pain, or coughing up blood (possible pulmonary embolism).
- Severe headache, confusion, or visual changes (cerebral thrombosis).
Preparation & Prescription Requirements
- Sample: Peripheral blood (3 mL EDTA tube).
- Prescription: A doctor’s prescription is mandatory. Exception: Not required for pre‑surgical clearance, pregnancy‑related screening, or international travel health certificates (per DHA circular).
- Special Instructions: No fasting needed. Avoid hemolyzed samples; send at room temperature within 24 hours.
Clinical Indications and Referring Specialists
General Physicians
Initial workup for unexplained anemia, hemoglobinuria, or recurrent thrombosis; guides timely referral.
Primary Care Doctors
Front‑line screening in patients with fatigue, dark urine, or abnormal CBC suggestive of bone marrow failure.
Anti‑Aging & Wellness Specialists
Comprehensive longevity panels; detects occult PNH clones in asymptomatic populations with mild cytopenias.
Frequently Asked Questions
What does the PNH Comprehensive Workup measure?
This test quantifies the percentage of blood cells missing GPI‑anchored proteins, using the FLAER probe and lineage markers CD14, CD15, CD24, CD45, CD59, CD64, and Glycophorin A to identify PNH clones with high sensitivity. يقيس هذا الاختبار النسبة المئوية لخلايا الدم غير الحاملة لبروتينات GPI، مستخدماً مسبار FLAER والواسمات CD14 وCD15 وCD24 وCD45 وCD59 وCD64 وGlycophorin A لتحديد نسخ PNH بدقة عالية.
How should I prepare for the?
No fasting is required; simply provide a peripheral blood sample. Inform your phlebotomist if you received a transfusion in the last two weeks, as this may affect clone detection accuracy. لا يستدعي الفحص الصيام، يكفي تقديم عينة دم وريدي. أبلغ طاقم السحب إن كنت قد تلقيت نقلاً دموياً خلال الأسبوعين الماضيين لتجنب تأثر دقة الكشف.
When will I receive my results and how are they interpreted?
Results are ready within 1–2 days and reported as percentage of PNH clones in granulocytes, monocytes, and red blood cells. A hematologist should correlate the clone size with your clinical symptoms and other laboratory markers. تصدر النتائج خلال 1–2 يوم وتُعبّر عن النسبة المئوية لنسخ PNH في الخلايا المحببة والوحيدات والكريات الحمراء. يجب على طبيب أمراض الدم ربط حجم النسخة بالأعراض السريرية والمعطيات المخبرية الأخرى.
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توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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