Test Price
700 AEDโ Home Collection Available
MAF/IGH FISH Test (Multiple Myeloma Translocation) in UAE โ 700 AED โ DHA Licensed
Executive Summary & Core Metrics
Executive Summary
- โ 99.9% diagnostic precision via ISO-accredited processing pipeline.
- โ Hospital extraction only โ bone marrow aspiration performed in accredited facility; mobile home phlebotomy disabled for safety.
- โ Post-test teleconsultation with a consultant medical geneticist for result interpretation and clinical guidance.
- โ Insurance coverage verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The MAF/IGH FISH test detects the t(14;16)(q32;q23) translocation, a high-risk cytogenetic abnormality strongly associated with aggressive multiple myeloma and poor prognosis. This highly sensitive fluorescence in-situ hybridization assay identifies the fusion of the IGH gene on chromosome 14 and the MAF oncogene on chromosome 16, providing crucial information for risk stratification and treatment personalization in plasma cell disorders.
Why Our Test Leads
| Feature | Our MAF/IGH FISH Test | Conventional Cytogenetics |
|---|---|---|
| Precision | >99% diagnostic sensitivity for t(14;16) using dual-color, dual-fusion probes | ~60โ70% sensitivity; limited by culture failure and low metaphase yield |
| Method | FISH (no cell culture required) โ directly targets IGH/MAF fusion | Karyotyping with G-banding; requires viable dividing cells |
| Turnaround | 3โ4 business days | 7โ14 days |
| Sample | Bone marrow aspirate or peripheral blood | Bone marrow only |
Physician Insight & Safety Protocols
โA positive MAF/IGH FISH result identifies a high-risk cytogenetic subgroup in multiple myeloma. This finding must be integrated with serum biomarkers, bone marrow histology, and the patientโs overall performance status to guide therapy. Our multidisciplinary team ensures every result is interpreted in full clinical context, enabling personalized treatment decisions including intensified regimens and early transplant evaluation.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA: 9294403
Medication Advisory
Important Medication Advisory
Do not discontinue any prescribed therapy, including anti-myeloma agents or supportive medications, without consulting your treating physician. Abrupt changes may compromise disease control and lead to adverse outcomes.
Safety Exclusion Criteria & Red Flags
- Exclusion: Severe coagulopathy (INR >1.5, platelet count <50,000/ฮผL) or active infection at the bone marrow aspiration site are contraindications for bone marrow sampling.
- Exclusion: Patients unable to lie prone or in a stable lateral position for the procedure may require alternative arrangements.
- Red Flag: If after sample collection you develop excessive bleeding, expanding hematoma, severe pain, or fever >38ยฐC, seek immediate emergency care.
- Red Flag: Signs of anaphylaxis โ difficulty breathing, facial swelling, rapid heartbeat โ call 998 or proceed to the nearest emergency department.
Patient FAQ & Clinical Guidance
1. What does a positive MAF/IGH FISH result mean for my myeloma prognosis?
First-Line Insight: MAF/IGH translocation t(14;16) is a high-risk genetic change that drives aggressive multiple myeloma and therapy resistance. This rearrangement causes overexpression of the MAF oncogene, accelerating proliferation and reducing response to standard-risk treatments. Patients with this abnormality are advised to receive intensive protocols including proteasome inhibitors, immunomodulatory drugs, and early evaluation for stem cell transplantation if eligible.
2. How is the MAF/IGH FISH test performed and what sample is required?
First-Line Insight: The test uses fluorescent DNA probes on bone marrow cells to detect the IGH/MAF fusion. A small bone marrow sample is aspirated from the hip bone under local anesthesia. Peripheral blood may be used if circulating plasma cells are present, but bone marrow remains the standard specimen. The aspiration procedure takes approximately 15โ20 minutes and is conducted in an accredited hospital facility. Hospital extraction only โ mobile home phlebotomy is disabled for safety.
3. Does my insurance cover the MAF/IGH FISH test and how do I verify?
First-Line Insight: Most UAE insurance plans cover cytogenetic testing when medically necessary; we verify coverage instantly via WhatsApp. Send your Emirates ID and policy number to +971 54 548 8731, and our billing team will confirm eligibility and any required copay before sample collection. Our direct billing facility eliminates upfront payment for many major insurers.
UAE Regulatory & Data Privacy Adherence
Data Privacy & Health Information Governance: Your genetic data is processed under the strictest confidentiality frameworks. This service complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All clinical procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability to ensure patient safety and informed consent. Your information is used solely for diagnostic purposes and is never shared without your explicit authorization.
Clinical & Logistical Metadata
| Test Name | MAF/IGH FISH Test (Multiple Myeloma Translocation) |
| Price (AED) | 700 |
| Turnaround Time | 3โ4 business days |
| Sample Type / Matrix | Bone Marrow Aspirate (Primary) / Peripheral Blood (Alternative) โ Hospital Extraction Only |
| Methodology Used | Fluorescence In-Situ Hybridization (FISH) |
| ICD-10-CM Code | C90.0 |
| LOINC Code | 49498-9 |
| DHA Facility License & Address | License 1143 โ Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE โ DNA Labs UAE |
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