Test Price
850 AEDโ Home Collection Available
IGH Gene Break Apart (14q32.3) FISH Test in UAE | 850 AED | DNA Labs UAE
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.
- Logistics: Hospital Extraction Only โ Bone marrow collection is conducted strictly within an accredited hospital facility; mobile home phlebotomy is disabled for safety.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance with result interpretation by Mr. Prabhakar Reddy Kalathoor's team.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The IGH Break Apart FISH test is a targeted molecular assay that detects translocations involving the IGH gene at 14q32.3, essential for diagnosing and prognosticating B-cell leukemias and lymphomas. This fluorescence in-situ hybridization (FISH) based analysis provides high-resolution detection of cryptic IGH rearrangements, guiding targeted therapy and risk stratification.
| Feature | Our Test (IGH Break Apart FISH) | Closest Alternative (Conventional Karyotyping) |
|---|---|---|
| Precision/Resolution | High โ detects cryptic IGH rearrangements at gene level | Low โ requires dividing cells, misses submicroscopic changes |
| Methodology | Fluorescence In-Situ Hybridization (FISH) โ ISO 9001:2015 Accredited | G-banded karyotype analysis |
| Turnaround Time | 4 working days | 7โ14 working days |
Physician Insight & Safety Protocols
"As a Specialist Diagnostic Radiology, I emphasize that FISH results should always be integrated with clinical history, morphology, and immunophenotyping. No single test defines the final diagnosis; a comprehensive multidisciplinary approach ensures accurate stratification and personalized treatment decisions."
โ Mr. Prabhakar Reddy Kalathoor, Specialist Diagnostic Radiology | DHA Registration ID: 61713011
Medication & Clinical Advisory
Important: Do not discontinue prescribed medication without consulting your doctor. This test is complementary and should not influence immediate therapy changes. Always consult with your hematologist or oncologist before making medical decisions.
Safety Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Active systemic infection, uncorrected severe coagulopathy (INR > 2.0, platelets < 20,000/ยตL) for bone marrow aspiration; history of severe vasovagal syncope without medical supervision.
- Emergency Red Flags Post-Collection: Persistent bleeding at puncture site, fever >38.5°C, severe local pain or hematoma. Seek immediate medical attention at the nearest emergency department.
Patient FAQ & Clinical Guidance
1. What is the IGH Break Apart FISH test and why is it needed?
The IGH Break Apart FISH test precisely identifies IGH gene rearrangements critical for leukemia diagnosis. This detects breaks in the IGH gene region on chromosome 14, which can fuse with other oncogenes, driving malignancies such as acute lymphoblastic leukemia, chronic lymphocytic leukemia, and multiple myeloma. Identifying the specific rearrangement guides targeted therapy and prognosis.
2. How is the sample collected and what are the preparation requirements?
Sample collection involves venipuncture for peripheral blood or bone marrow aspiration performed under sterile conditions within a hospital setting. No fasting is required for blood collection. A completed Chromosome & FISH Requisition Form 17 is mandatory. Peripheral blood is drawn into a green-top sodium heparin tube; bone marrow biopsy requires local anesthesia and is a hospital-only procedure. Samples must be shipped at 18โ22°C and never frozen to preserve cell viability.
3. What do the results mean and how will I receive them?
A 'positive' IGH break apart result indicates an IGH gene rearrangement detected, while a 'negative' result shows no rearrangement within the tested probe coverage. Results are reported as 'rearranged' or 'not rearranged' with detailed interpretation by our molecular pathologists. You will receive a secure digital report within 4 working days, and a free telephonic consultation with Mr. Prabhakar Reddy Kalathoorโs team to explain clinical implications and next steps.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance & Data Protection Framework
DNA Labs UAE operates under DHA Facility License Number 1143, strictly adhering to the Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical testing safety and patient consent protocols are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability. All genomic data is encrypted and processed within secure UAE-based infrastructure.
Clinical & Logistical Metadata
| Test Name | IGH Gene Break Apart (14q32.3) FISH |
| Price (AED) | 850 AED |
| Turnaround Time | 4 working days |
| Sample Type / Matrix | Peripheral Blood (Green-top Sodium Heparin Tube) or Bone Marrow Aspirate (Hospital-Only Procedure) |
| Methodology Used | Fluorescence In-Situ Hybridization (FISH) |
| ICD-10-CM Code | C91.9, C92.9, C90.0 |
| LOINC Code | 60528-5 |
| DHA Facility License & Address | License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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