Test Price
750 AEDโ Home Collection Available
FISH t(12;21) (TEL/AML1) Translocation Detection โ ETV6-RUNX1 Gene Fusion Test in Dubai
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Fluorescence In Situ Hybridization (FISH) processing.
- Premium Logistics: Hospital Extraction Only โ Sample collection is conducted strictly within an accredited hospital facility; mobile home phlebotomy is disabled for safety. Secure medical courier retrieval is arranged for oncology clinics.
- Clinical Guidance: Telephonic post-test consultation with a specialist for result interpretation and clinical correlation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The FISH t(12;21) (TEL/AML1) test is a high-resolution molecular cytogenetic assay that detects the ETV6-RUNX1 gene fusion resulting from the t(12;21)(p13;q22) translocation. This cryptic rearrangement is the most common genetic abnormality in pediatric B-cell acute lymphoblastic leukemia (B-ALL) and is strongly associated with a favorable prognosis when managed with appropriate risk-adapted therapy. The assay utilizes dual-color fusion probe fluorescence in situ hybridization to analyze both interphase nuclei and metaphase chromosomes, ensuring >99% sensitivity for the target translocation.
Comparative Advantage Over Standard Cytogenetics
| Parameter | Our FISH t(12;21) Test | Standard Karyotyping (Alternative) |
|---|---|---|
| Methodology | Fluorescence In Situ Hybridization (dual-color fusion probes) | G-banded chromosome analysis |
| Sensitivity & Resolution | Detects translocation in 200+ interphase cells; >99% sensitivity | Requires dividing cells; resolution ~5-10 Mb |
| Turnaround Time | 4 working days | 10-14 days |
| Sample Types | Whole blood (sodium heparin) or bone marrow aspirate (green top tube) | Bone marrow aspirate only |
| Price | 750 AED | ~1,200-1,500 AED |
Physician Insight & Safety Protocols
โThe FISH t(12;21) assay is an indispensable tool in the diagnostic workup of B-ALL, particularly in pediatric patients. A positive ETV6-RUNX1 fusion signal indicates a favorable-risk genetic subgroup that typically responds well to intensified chemotherapy protocols. However, no single molecular result should be interpreted in isolation. Comprehensive risk stratification, including minimal residual disease monitoring by flow cytometry or PCR, is paramount for guiding therapy. As a consultant, I strongly advise integrating this FISH result with the patientโs full hematological profile before making any treatment decisions.โ
โ Mr. Prabhakar Reddy Kalathoor, Specialist Diagnostic Radiology | DHA Registration ID: 61713011
Advisory: Medical Precautions & Medication Continuation
Do not discontinue, adjust, or modify any prescribed anti-leukemic medication or supportive therapy without explicit instruction from your treating hematologist or oncologist. The FISH t(12;21) test is a diagnostic and monitoring tool; it is not a substitute for clinical judgment or a complete medical evaluation.
Exclusion Criteria & Procedural Red Flags
- Bone marrow collection risks: Patients with severe thrombocytopenia (platelets <20ร10โน/L) or uncorrected coagulopathy require platelet transfusion or medical optimisation prior to aspiration.
- Specimen integrity: Do not freeze the sample; maintain whole blood/bone marrow at 18โ22ยฐC during transport. Use only sodium heparin (green top) tubes.
- Mandatory form: A fully completed Chromosome & FISH Analysis Requisition Form (Form 17) must accompany the sample; failure delays processing.
- Urgent medical warning: If after collection you experience fever >38ยฐC, uncontrolled bleeding, rapidly expanding hematoma at the puncture site, or shortness of breath, seek emergency medical attention immediately.
Patient FAQ & Clinical Guidance
1. What is the FISH t(12;21) test used for in leukemia diagnosis?
The FISH t(12;21) test detects the ETV6-RUNX1 gene fusion that defines a common chromosomal rearrangement in pediatric B-cell acute lymphoblastic leukemia. This result helps oncologists classify the patient into a favorable prognostic group, guides the intensity of chemotherapy, and serves as a sensitive marker for monitoring minimal residual disease after treatment.
2. How is the sample collected and what is the turnaround time?
Sample collection requires either a peripheral whole blood draw into a sodium heparin (green top) tube or a bone marrow aspirate performed under local anaesthesia by an experienced clinician. This is a hospital-only procedure; home phlebotomy is not available for this test due to specimen integrity requirements. Results are delivered within 4 working days from receipt of the sample and complete requisition paperwork.
3. Does my insurance cover the cost of 750 AED?
Most major UAE health insurers, including Daman, AXA, and Neuron, provide coverage for FISH-based genetic testing when ordered by an oncologist. Direct billing can be verified instantly via WhatsApp at +971 54 548 8731. Our billing team will assist with pre-approval and explain any co-payment requirements specific to your policy.
UAE Regulatory & Data Privacy Adherence
Legal & Compliance Framework
This FISH t(12;21) test is conducted in strict compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical testing safety and patient consent adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Our laboratory holds ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139) and operates under DHA license number 1143, ensuring international quality management, data security, and patient confidentiality standards.
Clinical & Logistical Metadata
| Test Name | FISH t(12;21) (TEL/AML1) Translocation Detection โ ETV6-RUNX1 Gene Fusion |
| Price (AED) | 750 AED |
| Turnaround Time | 4 working days |
| Sample Type / Matrix | Whole blood (sodium heparin โ green top) or bone marrow aspirate |
| Methodology Used | Fluorescence In Situ Hybridization (FISH) โ dual-color fusion probe interphase and metaphase analysis |
| ICD-10-CM Code | C91.00 (Acute lymphoblastic leukemia, not having achieved remission) |
| LOINC Code | 34973-7 (Chromosome translocation t(12;21)(p13;q22) [Presence] in Blood or Bone Marrow by FISH) |
| DHA Facility License & Address | DHA License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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