Test Price
750 AED✅ Home Collection Available
FISH for Trisomy 21 (Down Syndrome) in UAE | 750 AED
Executive Summary & Core Metrics
Executive Summary
- Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 accredited processing (Cert: INT/EGQ/2509DA/3139)
- Limited Logistics: Hospital extraction only – sample collection is conducted strictly within an accredited hospital facility; mobile home phlebotomy is disabled for safety.
- Clinical Guidance: Telephonic post-test clinical guidance in result interpretation
- Insurance: Direct billing verification via WhatsApp +971 54 548 8731
Test Overview & Methodology
The FISH (Fluorescence In-Situ Hybridization) test for Trisomy 21 rapidly detects an extra copy of chromosome 21 in fetal cells from amniotic fluid, chorionic villus sampling (CVS), or cord blood, providing a definitive prenatal diagnosis of Down syndrome within 4 days. This targeted molecular cytogenetic technique offers >99% accuracy and is a cornerstone of modern prenatal genetic care in the UAE.
| Feature | Our Test (FISH) | Closest Alternative (Karyotype) |
|---|---|---|
| Methodology | Fluorescence In-Situ Hybridization | Cell culture & chromosomal banding |
| Turnaround Time | 4 days | 10–14 days |
| Precision for Trisomy 21 | >99% | >99.5% (but requires viable cells) |
| Sample Types | Amniotic fluid, CVS, cord blood | Same, plus fibroblasts |
Physician Insight & Safety Protocols
"FISH results for Trisomy 21 must always be correlated with ultrasound findings and detailed family history. A single test cannot tell the full clinical story. A positive result is exceedingly reliable, but a negative result does not exclude other chromosomal anomalies that may require full karyotyping. Please refrain from making any irreversible decisions before discussing the report with your genetic counselor or obstetrician."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory: Post-Test Medication and Management
Medication Warning: Do not discontinue prescribed medication without consulting your doctor.
Any adjustment to maternal or fetal management must be made under direct medical supervision, irrespective of the test outcome.
Exclusion Criteria & Safety Red Flags
- Contraindicated in active vaginal bleeding, placenta previa, severe maternal coagulopathy, or known allergy to sodium heparin.
- Not recommended if there is an active uterine infection or if the mother has a significant risk of preterm labor.
- Emergency Red Flags: Seek immediate medical care if you experience severe abdominal pain, heavy vaginal bleeding, fluid leakage, or fever >38°C following the invasive sampling procedure.
Patient FAQ & Clinical Guidance
1. What is the FISH test for Down syndrome?
The FISH test is a rapid prenatal molecular assay that detects an extra chromosome 21 in fetal cells, confirming Down syndrome with over 99% accuracy within 4 days. It uses fluorescent DNA probes that bind specifically to chromosome 21 regions, providing a faster answer than traditional karyotyping.
2. How is the sample collected for the Trisomy 21 FISH in Dubai?
Sample collection involves a minimally invasive procedure—amniocentesis, CVS, or cordocentesis—performed by a skilled specialist under continuous ultrasound guidance. The sample must be collected in an accredited hospital setting; home collection is not available for this test due to the invasive nature of the procedure. A duly filled Chromosome & FISH analysis Requisition Form (Form 17) and Prenatal Genetic Testing Consent Form (Form 18) are mandatory prior to collection.
3. What do a positive or negative FISH result mean?
A positive result indicates Trisomy 21 with over 99% certainty, while a negative result rules out the common aneuploidy but may still require a full karyotype to exclude other chromosomal rearrangements. All results should be interpreted alongside your obstetrician’s ultrasound findings and genetic counseling.
UAE Regulatory & Data Privacy Adherence
Regulatory & Privacy Compliance
- Data Protection: Fully compliant with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Health Information Use: Adheres to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Medical Liability & Consent: All procedures follow Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring informed consent and patient safety.
- Lab Accreditation: ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139), DHA/MOHAP standardised.
Clinical & Logistical Metadata
| Test Name | FISH for Trisomy 21 (Down Syndrome) |
| Price (AED) | 750 |
| Turnaround Time | 4 days |
| Sample Type / Matrix | Amniotic fluid, Chorionic villus (CVS), Cord blood |
| Methodology Used | Fluorescence In-Situ Hybridization (FISH) |
| ICD-10-CM Code | Q90.0 (Trisomy 21, nonmosaicism), Q90.9 (Down syndrome, unspecified), Z36.0 (Encounter for antenatal screening for chromosomal anomalies) |
| LOINC Code | 53177-3 (Chromosome 21 aneuploidy in Amniotic fluid by FISH) |
| DHA Facility License & Laboratory Address | DHA License: 1143, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE. Lab: DNA Labs UAE |
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