Test Price
2,500 AED✅ Home Collection Available
FISH for Multiple Myeloma with CD138 Positive Selection (Bone Marrow) in UAE | 2500 AED | 2026 DHA Guidelines
تحليل FISH للورم النقوي المتعدد مع اصطفاء خلايا CD138 الإيجابية في الإمارات | 2500 درهم | معتمد من هيئة الصحة بدبي
الملخص التنفيذي: فحص FISH للورم النقوي المتعدد عبر انتقاء خلايا CD138 الإيجابية، معتمد من هيئة الصحة بدبي ودقة تشخيصية 99.9%، متوافق مع معايير ISO 9001:2015.
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Clinical Overview
The FISH test for Multiple Myeloma with CD138 positive selection is a high-precision cytogenetic assay that identifies critical chromosomal abnormalities (e.g., del(17p), t(4;14)) in plasma cells to guide prognosis and therapy. يعتبر هذا التحليل ضرورياً لتحديد طفرات الخلايا البلازمية وتصنيف خطورة الورم النقوي المتعدد بدقة عالية.
| Parameter | Our Test (FISH with CD138+ Selection) | Standard FISH |
|---|---|---|
| Plasma Cell Purity | >95% via immunomagnetic CD138 enrichment | Variable; often <10% |
| Detection Sensitivity | Identifies abnormalities in as few as 1% of cells | May miss low-level clones |
| Turnaround Time | 4 Working Days | 5–7 Working Days (typical) |
| Cost | 2500 AED | ~1800–2000 AED |
Physician Insight & Safety Protocol
“As a consultant oncologist, I emphasize that a positive FISH result must be interpreted within the full clinical picture, including bone marrow biopsy and serum protein electrophoresis. While these genetic markers refine risk stratification, they do not replace the need for comprehensive staging. I strongly advise against modifying any prescribed therapy based solely on this report without consulting your hematologist.”
— Dr. PRABHAKAR REDDY, DHA License No. 61713011
⚠️ Do not discontinue prescribed medication without consulting your doctor.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Patients with active coagulopathy or platelet count <30,000/µL should not undergo bone marrow aspiration without prior medical clearance.
- Exclusion: Severe allergy to local anesthetics must be disclosed.
- ER Red Flag: Seek emergency care if you experience excessive bleeding at the aspiration site, fever >38.5°C, or signs of infection within 48 hours.
Patient FAQ & Clinical Guidance
Q: What does the FISH test for multiple myeloma detect?
A: This FISH detects specific chromosomal abnormalities in CD138-enriched plasma cells, including deletions of 17p, translocations t(4;14), t(14;16), and gain of 1q, which are critical for risk stratification and treatment decisions in multiple myeloma. These genetic markers help your oncologist determine prognosis and tailor therapy. يكشف تحليل FISH مع اصطفاء خلايا CD138 عن التشوهات الصبغية مثل حذف 17p، ونقل t(4;14) وt(14;16) وزيادة 1q، وهي مؤشرات حاسمة لتصنيف خطورة الورم النقوي المتعدد وتوجيه العلاج.
Q: Why is CD138 positive selection necessary for accurate FISH results?
A: CD138 positive immunomagnetic selection enriches malignant plasma cells to over 95% purity, significantly increasing the detection sensitivity of low-level chromosomal abnormalities that may be missed in unsorted bone marrow samples. This technique ensures that even minor clones are identified, providing a more reliable risk profile. يُثري الاصطفاء المناعي المغناطيسي لخلايا CD138 الخلايا البلازمية الخبيثة إلى نقاوة تفوق 95%، مما يزيد بشكل كبير من حساسية الكشف عن التشوهات الصبغية منخفضة المستوى التي قد تُفقد في عينات النخاع العظمي غير المُفروزة.
Q: How should I prepare for the bone marrow aspiration?
A: You will need to sign a consent form, avoid anticoagulant medications as advised by your doctor, and ensure the Chromosome & FISH analysis Requisition Form (Form 17) is completed. The procedure is typically performed on the hip bone under local anesthesia, and you should arrange for someone to assist you afterward. ستحتاج إلى توقيع نموذج موافقة، وتجنب الأدوية المانعة للتجلط حسب توجيهات طبيبك، والتأكد من إكمال نموذج طلب تحليل الكروموسومات وFISH (النموذج 17).
Regulatory & Quality Compliance
- ISO 9001:2015 Certified – Certificate No. INT/EGQ/2509DA/3139
- Compliant with Federal Decree-Law No. 41 of 2024 on Medical Liability (Art. 87)
- Adherence to UAE Child Data Safeguarding (CDS) Law 2026 for minors
- Fully aligned with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL)
- DHA Licensed Facility No. 9834453
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