Test Price
1,200 AED✅ Home Collection Available
FISH for Ewing Sarcoma (EWSR1 Rearrangement, 22q12) – Definitive Molecular Confirmation
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing. Premium Logistics: Secure Medical Courier Solid Tissue Specimen Retrieval with ISO Certified Cold-Chain. Clinical Guidance: Complimentary Telephonic Post-Test Clinical Guidance for result interpretation. Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
ISO 9001:2015 Cert: INT/EGQ/2509DA/3139 | DHA Facility License: 1143 | Support: +971545488731
Test Overview & Methodology
The FISH for Ewing Sarcoma test precisely identifies the EWSR1 (22q12) gene rearrangement, the hallmark molecular alteration in Ewing sarcoma and related primitive neuroectodermal tumors. It is performed on formalin‑fixed paraffin‑embedded (FFPE) tissue blocks using fluorescence in‑situ hybridization, delivering a definitive diagnostic result within 7–8 working days. This assay employs a dual‑color break‑apart probe strategy to detect rearrangements involving the EWSR1 locus with >99% analytical sensitivity and specificity.
| Feature | Our FISH Test | Closest Alternative (NGS Panel) |
|---|---|---|
| Precision | >99% analytical sensitivity & specificity for EWSR1 break‑apart | Broader fusion detection but lower per‑target depth |
| Methodology | Fluorescence In‑Situ Hybridization (FISH) – DHA/MOHAP Standard | RNA‑based next‑generation sequencing (NGS) |
| Speed | 7–8 working days | Typically 14–21 days |
| Sample | FFPE tissue block (≥10% tumor) | FFPE or fresh tissue (higher tumor requirement) |
| Price | 1,200 AED | Often 2,500–4,000 AED |
Physician Insight & Safety Protocols
“FISH for EWSR1 rearrangement provides the definitive molecular anchor in diagnosing Ewing sarcoma, enabling precise risk stratification and targeted therapy selection. The test must always be interpreted alongside histopathology and imaging. Our laboratory ensures rigorous quality control on every FFPE block before reporting.” — Mr. Prabhakar Reddy Kalathoor, Specialist Diagnostic Radiology, DHA Registration ID: 61713011
Medication Advisory & Clinical Precautions
Medication Safety Notice
Do not discontinue, adjust, or initiate any prescribed oncologic therapy based solely on this FISH result without consulting your treating specialist. This diagnostic finding must be integrated into a comprehensive clinical assessment that includes radiological staging and histopathological review.
Exclusion Criteria & Emergency Red Flags
- Insufficient Tumor Content: FFPE block with <10% tumor cellularity – specimen unsuitable for reliable FISH analysis.
- Technical Artifacts: Improperly fixed, over‑decalcified, or necrotic tissue may produce false‑negative or inconclusive results.
- Clinical Red Flags (seek immediate medical attention): Sudden severe bone pain, pathological fracture, new neurological deficits, or signs of spinal cord compression.
Patient FAQ & Clinical Guidance
1. What does the FISH test for Ewing sarcoma detect, and why is it essential?
1. What does the FISH test for Ewing sarcoma detect, and why is it essential?
This FISH test detects the EWSR1 gene rearrangement at 22q12, confirming Ewing sarcoma diagnosis for targeted therapy. It uses fluorescent probes on formalin‑fixed tissue to visualize the break‑apart signal unique to Ewing family tumors. A positive result guides enrollment in clinical trials and selection of precision treatments. The assay achieves >99% analytical sensitivity for the canonical EWSR1‑FLI1 fusion and its variant translocations.
2. How should the sample be collected and shipped?
2. How should the sample be collected and shipped?
Archival Tissue Specimen – Secure Medical Courier Solid Tissue Specimen Retrieval. Submit a formalin‑fixed paraffin‑embedded tissue block containing at least 10% tumor tissue shipped at room temperature via our secure medical courier. The block must be accompanied by a duly filled Chromosome & FISH Analysis Requisition Form (Form 17). Mobile home phlebotomy is disabled for this test as it requires surgical or biopsy‑derived tissue.
3. Is this test covered by UAE medical insurance?
3. Is this test covered by UAE medical insurance?
Most UAE insurers cover this FISH assay when pre‑authorization is obtained through our direct billing verification service. Send your insurance card via WhatsApp to +971 54 548 8731 for instant eligibility checking and approval assistance under DHA/MOHAP guidelines. Our team coordinates with your insurer to confirm coverage and obtain the necessary pre‑certification.
4. How long does it take to receive results, and how are they communicated?
4. How long does it take to receive results, and how are they communicated?
Results are delivered within 7–8 working days from the date the FFPE block is received and verified by our laboratory. You will receive a secure digital PDF report via WhatsApp and email, with a complimentary telephonic post‑test clinical guidance session to help interpret the findings and plan next steps.
5. What are the limitations of the FISH test compared to other methods?
5. What are the limitations of the FISH test compared to other methods?
FISH is highly specific for EWSR1 rearrangements but does not detect fusion partners beyond the break‑apart signal. NGS panels can identify the exact fusion transcript and additional co‑occurring mutations, though at a higher cost and longer turnaround time. FISH remains the gold standard for initial diagnosis due to its speed, cost‑effectiveness, and robust performance on archival FFPE tissue.
UAE Regulatory & Data Privacy Adherence
Data Protection & Health Information Governance
All patient data and genetic test results are processed in strict compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Your genetic information is encrypted, access‑controlled, and never shared without explicit written consent. DNA Labs UAE maintains ISO 9001:2015 certification (INT/EGQ/2509DA/3139) and operates under DHA Facility License 1143.
Clinical & Logistical Metadata
| Test Name | FISH for Ewing Sarcoma (EWSR1 Rearrangement, 22q12) |
| Price (AED) | 1,200 AED |
| Turnaround Time | 7–8 Working Days |
| Sample Type / Matrix | Formalin‑Fixed Paraffin‑Embedded (FFPE) Tissue Block – Archival Tissue Specimen. Secure Medical Courier Solid Tissue Specimen Retrieval (mobile home phlebotomy disabled). |
| Methodology Used | Fluorescence In‑Situ Hybridization (FISH) – Dual‑Color Break‑Apart Probe Strategy |
| ICD-10-CM Code | C41.9 |
| LOINC Code | 49490-4 |
| DHA Facility License & Laboratory Address | License 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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