Test Price
950 AED✅ Home Collection Available
FISH for 17p (TP53) Deletion Test in UAE | 950 AED | DHA Licensed
Executive Summary & Core Metrics
Executive Summary: This fluorescence in-situ hybridization (FISH) test precisely detects deletion of the TP53 tumour suppressor gene on chromosome 17p — a high‑risk prognostic marker in multiple myeloma. With 99.9% diagnostic sensitivity, the assay is performed on interphase nuclei from bone marrow aspirate. Hospital Extraction Only – Sample collection is conducted strictly within an accredited hospital facility; mobile home phlebotomy is disabled for safety. Results are reported within 4 working days by ISO‑certified laboratories. Direct insurance billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The FISH for 17p (TP53) deletion test identifies loss of the TP53 gene using fluorescent probes targeting the 17p13.1 locus. This highly specific molecular cytogenetic method provides critical prognostic stratification for multiple myeloma patients, enabling tailored treatment decisions. The assay is performed on interphase nuclei obtained from bone marrow aspirate collected under sterile hospital conditions.
| Feature | Our Test | Closest Alternative |
|---|---|---|
| Precision | 99.9% Diagnostic Sensitivity, targeted FISH probes for 17p13.1 | Standard karyotyping (lower resolution, 5–10% false‑negative rate) |
| Methodology | Fluorescence In‑Situ Hybridization (FISH) on interphase nuclei | Conventional cytogenetics / G‑banding |
| Turnaround Time | Report within 4 days (sample by 4 pm) | 7–14 days for karyotype, often requiring repeat cultures |
Physician Insight & Safety Protocols
Insight from Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA ID: 9294403): This FISH assay provides highly reliable detection of TP53 deletion in multiple myeloma. However, a negative result does not exclude other high‑risk genetic abnormalities. All findings must be correlated with clinical history, serum protein electrophoresis, and bone marrow morphology. Treatment decisions should never rely solely on a single genetic test.
Advisory Note
Important: Do not discontinue or adjust any prescribed medication without direct consultation with your managing oncologist. Always bring a complete list of current medications to the hospital collection appointment.
Exclusion Criteria & Emergency Red Flags
- Active infection with fever >38°C at the time of scheduled collection – reschedule once afebrile.
- Severe thrombocytopenia (platelets <30 × 10⁹/L) without haematologist clearance – risk of bleeding/haematoma.
- Known allergy to sodium heparin – alternative anticoagulant must be discussed with the laboratory.
- If you experience unprovoked bleeding, severe bone pain, sudden vision changes, or confusion, seek emergency care immediately.
Patient FAQ & Clinical Guidance
1. What does a TP53 deletion on 17p mean for my multiple myeloma?
Answer: A TP53 deletion indicates a high‑risk myeloma subtype that often shows aggressive behaviour and may require more intensive treatment approaches, but your oncologist will interpret the result alongside your complete clinical picture.
2. How should I prepare for the sample collection?
Answer: Ensure the mandatory Chromosome & FISH analysis Requisition Form (Form 17) is fully completed and signed by your referring physician; no fasting or medication changes are required unless specifically instructed by your doctor.
3. Is this test covered by insurance and where is it performed?
Answer: This is a hospital‑only procedure performed at accredited facilities under the supervision of a Consultant Medical Genetics. Send your insurance details via WhatsApp at +971 54 548 8731 to verify direct billing eligibility. Collection is not available at home.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance: This test is performed in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient safety and consent procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. All data handling meets DHA and UAE data protection standards.
Clinical & Logistical Metadata
| Test Name | FISH for 17p (TP53) Deletion Test |
| Price (AED) | 950 |
| Turnaround Time | 4 working days |
| Sample Type / Matrix | Bone marrow aspirate (hospital extraction only) |
| Methodology Used | Fluorescence In-Situ Hybridization (FISH) on interphase nuclei |
| ICD-10-CM Code | C90.00 (Multiple myeloma not having achieved remission) |
| LOINC Code | 76590-2 (TP53 gene rearrangement and deletion analysis in bone marrow by FISH) |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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