Test Price
2,800 AEDโ Home Collection Available
ACTA2 Gene (Familial Thoracic Aortic Aneurysm Type 6) Genetic Test in Dubai, UAE
Executive Summary & Core Metrics
Executive Summary: This premium NGS-based genetic test delivers 99.9% diagnostic sensitivity for detecting pathogenic ACTA2 variants, enabling proactive management of familial thoracic aortic aneurysm type 6. The service includes ISO-certified cold-chain home collection (8 AM to 11 PM), direct insurance billing support via WhatsApp +971 54 548 8731, and post-test DHA-licensed physician teleconsultation for result interpretation. DNA Labs UAE strictly adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
Test Overview & Methodology
The ACTA2 gene encodes smooth muscle alpha-actin; mutations cause familial thoracic aortic aneurysm and dissection (TAAD) type 6, a life-threatening condition. This test screens the entire coding region via next-generation sequencing (NGS), identifying pathogenic variants for accurate risk stratification and family screening.
| Feature | Our ACTA2 NGS Test | Conventional Sanger Sequencing |
|---|---|---|
| Precision & Sensitivity | 99.9% analytical sensitivity; full gene coverage | High per-exon accuracy but limited to pre-defined mutations |
| Methodology | Next-Generation Sequencing (NGS) with deep bioinformatic analysis | Single-exon capillary electrophoresis |
| Turnaround Time | 3 to 4 weeks | 4 to 6 weeks (multi-exon) |
| Gene Coverage | Complete coding region plus splice sites | Selected exons only |
| Cost-Effectiveness | Comprehensive at 2,800 AED | Cumulative cost escalates with each exon |
*Clinical validation performed on an ISO 9001:2015 certified platform.
Physician Insight & Safety Protocols
โUnderstanding your genetic risk for Thoracic Aortic Aneurysm is a profound step towards preventative healthcare. As a Consultant Medical Genetics specialist, I emphasize that a positive ACTA2 result provides a critical opportunity for life-saving surveillance and timely intervention. This test must always be interpreted alongside a complete clinical and family history by a qualified genetic counsellor or cardiologist.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Safety Advisory
Do not discontinue or modify any prescribed medication without direct consultation with your treating physician.
Clinical Exclusion Criteria & Emergency Red Flags
Exclusion Criteria
- Active uncontrolled systemic infection or sepsis
- Severe anemia (Hb <7 g/dL) limiting safe blood draw volume
- Inability to provide informed consent; for minors, consent must be provided by a legal guardian in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability
- Known coagulopathy not managed by a haematologist
Emergency Red Flags โ Seek Immediate Help
Sudden severe chest or back pain, shortness of breath, faintness, or loss of consciousness may signal acute aortic dissection. Call 998 or visit the nearest emergency department immediately.
Patient FAQ & Clinical Guidance
1. What is the ACTA2 gene test, and who should consider it?
This test analyzes the entire coding region of the ACTA2 gene via next-generation sequencing to detect mutations linked to familial thoracic aortic aneurysm type 6. It is indicated for individuals with a personal or family history of unexplained aortic dilation, dissection, or sudden cardiac death.
2. Is fasting required before sample collection?
No fasting is necessary. A standard venous blood draw is sufficient for high-quality DNA extraction. You may eat and drink normally before the appointment.
3. How long does it take to receive results?
The turnaround time is 3 to 4 weeks from sample receipt. This includes library preparation, deep sequencing, bioinformatic interpretation, and clinical report sign-off. Results are delivered securely via encrypted email or the patient portal.
4. How is the sample collected for this genetic test?
A peripheral whole blood sample is collected by our DHA-licensed phlebotomists. We offer VIP Mobile Phlebotomy with temperature-controlled cold-chain logistics for home collection, available daily from 8 AM to 11 PM.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE strictly adheres to the highest standards of data protection and patient confidentiality as mandated by Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted, securely stored, and processed exclusively for clinical diagnostic purposes with explicit patient consent. Our DHA facility license (Number: 1143) ensures compliance with Dubai Healthcare City regulatory frameworks.
Clinical & Logistical Metadata
| Test Name | ACTA2 Gene (Familial Thoracic Aortic Aneurysm Type 6) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 weeks |
| Sample Type / Matrix | Peripheral Whole Blood |
| Methodology Used | Next-Generation Sequencing (NGS) |
| ICD-10-CM Code | I71.2 |
| LOINC Code | 55247-0 |
| DHA Facility License & Laboratory Address | DNA Labs UAE, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | License: 1143 |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians