Test Price
2,800 AEDโ Home Collection Available
MSH3 Gene Familial Adenomatous Polyposis Type 4 Genetic Test โ 2,800 AED
Executive Summary & Core Metrics
This genetic test evaluates the MSH3 gene for pathogenic variants linked to attenuated familial adenomatous polyposis (AFAP) type 4, enabling early colorectal cancer risk stratification and surveillance planning. The test is performed in our ISO 9001:2015 accredited laboratory with 99.9% diagnostic sensitivity.
Test Overview & Methodology
The MSH3 Gene Familial Adenomatous Polyposis Type 4 Genetic Test uses next-generation sequencing (NGS) to analyze the entire coding region and conserved splice sites of the MSH3 gene. Pathogenic variants in MSH3 are associated with an attenuated form of familial adenomatous polyposis, characterized by fewer than 100 colorectal adenomas and a reduced risk of colorectal cancer if managed with regular surveillance. Our NGS platform provides superior sensitivity and accuracy compared to conventional Sanger sequencing, minimizing the chance of missed variants.
| Feature | Our Test (MSH3 Full Gene NGS) | Closest Alternative (Singleโgene Sanger Sequencing) |
|---|---|---|
| Precision | 99.9% sensitivity; full coding region & splice sites | 95โ97% sensitivity; limited to known hotspots |
| Methodology | Next Generation Sequencing (NGS) with Sanger confirmation | Capillary (Sanger) Sequencing |
| Turnaround Time | 3โ4 Weeks | 4โ6 Weeks |
Physician Insight & Safety Protocols
โIdentifying an MSH3 pathogenic variant should be seen as an opportunity for proactive colorectal health management. While it confers an increased lifetime risk for adenomatous polyps and colorectal cancer, adherence to a surveillance colonoscopy program every one to two years starting from age 20โ25 significantly reduces that risk. I advise all patients to undergo preโ and post-test genetic counselling to fully understand their results.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory โ Medication & Treatment Continuation
โ ๏ธ Important Caution
Do not discontinue any prescribed medications, dietary modifications, or screening schedules without consulting your physician. Genetic test results should complement, not replace, standard medical care.
Safety Exclusion Criteria & Emergency Red Flags
Conditions That May Affect Test Accuracy or Safety
- Blood transfusion or bone marrow transplant within the last 2 weeks (may interfere with germline DNA extraction).
- Inability or refusal to provide informed consent after genetic counselling.
- Active infection, fever, or haemodynamic instability โ defer elective testing.
- Emergency Red Flags: Sudden severe abdominal pain, visible rectal bleeding, or unexplained rapid weight loss require immediate medical attention. Call 999 or proceed to the nearest emergency department.
Patient FAQ & Clinical Guidance
1. What does a positive MSH3 gene variant mean for my colorectal cancer risk?
A positive result indicates an inherited predisposition to attenuated familial adenomatous polyposis (AFAP). While the risk of colorectal cancer is increased, regular colonoscopy every 1โ2 years beginning at age 20โ25 can effectively prevent cancer by removing precancerous polyps.
2. How is the sample collected, and is home collection available?
A certified phlebotomist will collect 2 mL of whole blood into a DNA-stabilizing tube during a scheduled home visit. The sample is transported under temperature-controlled cold chain to our ISO 9001:2015 accredited laboratory.
3. Is this test covered by UAE insurance?
Many UAE health insurance plans cover genetic testing when ordered with a referral from a genetic counsellor. Direct billing verification is available via WhatsApp at +971 54 548 8731.
4. How long does it take to receive results?
Our standard turnaround time is 3 to 4 weeks from sample receipt. You will be notified when the report is ready and a genetic counsellor will schedule a telephonic consultation to review the findings.
UAE Regulatory & Data Privacy Adherence
Your data is protected under UAE federal law.
- All genetic and personal data are processed in compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Health information handling adheres to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Patient consent and medical liability protocols follow Federal Decree-Law No. 4 of 2016 on Medical Liability.
DNA Labs UAE is licensed by the Dubai Health Authority under facility number 1143 and operates in full conformity with DHA standards for genetic testing.
Clinical & Logistical Metadata
| Test Name | MSH3 Gene Familial Adenomatous Polyposis Type 4 Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 Weeks |
| Sample Type / Matrix | Whole Blood (Peripheral) โ 2 mL in DNA stabilising tube |
| Methodology Used | Next Generation Sequencing (NGS) with Sanger confirmation |
| ICD-10-CM Code | Z15.09 |
| LOINC Code | 21636-6 |
| DHA Facility License & Address | License 1143 โ Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians