Factor IX Functional Test
Overview
Factor IX is a clotting factor that plays a crucial role in the coagulation cascade. It is a glycoprotein produced in the liver and is essential for the normal blood clotting process. The factor IX functional test is a laboratory test that measures the activity level of factor IX in the blood. This test is used to diagnose and monitor bleeding disorders, such as hemophilia B (also known as Christmas disease), which is characterized by a deficiency or dysfunction of factor IX.
Test Details
The factor IX functional test measures the activity level of factor IX in the blood. During the test, a blood sample is collected from the patient and mixed with a substance that triggers the clotting process. The time it takes for the blood to clot is measured, and the result is compared to a reference range to determine the level of factor IX activity. A normal factor IX activity level is typically between 50% and 150%. If the activity level is below this range, it indicates a deficiency or dysfunction of factor IX, which can lead to excessive bleeding or delayed clotting. The severity of the bleeding disorder can be determined based on the factor IX activity level.
Test Procedure
To perform the factor IX functional test, a sample of 3 mL whole blood is collected in 1 Blue Top (Sodium Citrate) tube. The sample should be mixed thoroughly by inversion and transported to the lab within 4 hours. If immediate transportation is not possible, the sample should be centrifuged to make platelet-poor plasma (PPP) within 1 hour of collection. The PPP should be frozen immediately and shipped frozen. It is recommended to fast overnight before the test, and a duly filled Coagulation Requisition Form (Form 15) is mandatory.
Report Delivery
The report for the factor IX functional test is delivered on Wednesdays and Saturdays by 9 am. If the sample is collected on a Friday or Tuesday, the report will be delivered on the following Friday or Tuesday.
Pre-Test Information
It is preferred to fast overnight before the test. A duly filled Coagulation Requisition Form (Form 15) is mandatory. It is recommended to discontinue the use of Heparin for 1 day and Oral Anticoagulants for 7 days prior to sampling, as these drugs may affect the test results. Discontinuation should be done with prior consent from the treating Physician.
Conclusion
The factor IX functional test is a valuable diagnostic tool for identifying and monitoring bleeding disorders, specifically hemophilia B. By measuring the activity level of factor IX in the blood, healthcare professionals can determine the severity of the bleeding disorder and develop an appropriate treatment plan. DNA Labs UAE offers the factor IX functional test at a cost of AED 410.0. Contact our Hematology department to schedule an appointment or for more information.
| Test Name | FACTOR IX FUNCTIONAL Test |
|---|---|
| Components | |
| Price | 410.0 AED |
| Sample Condition | 3 mL whole blood in 1 Blue Top (Sodium Citrate) tube. Mix thoroughly by inversion. Transport to Lab within 4 hours. If this is not possible,make PPP within 1 hour of collection as follows: Centrifuge sample at 3600 rpm for 15 min. & transfer supernatant to a clean plastic tube. Centrifuge this supernatant again at 3600 rpm for 15 mins. & finally transfer the supernatant (PPP) to 1 labelled, clean plastic screw capped vial. FREEZE IMMEDIATELY. Ship frozen. DO NOT THAW. Overnight fasting is preferred. Duly filled Coagulation Requisition Form (Form 15) is mandatory. |
| Report Delivery | SampleWed / Sat by 9 am; Report Fri / Tue |
| Method | Photo-optical Clot Detection |
| Test type | Disorders of Coagulation |
| Doctor | Hematologist |
| Test Department: | |
| Pre Test Information | Overnight fasting is preferred. Duly filled Coagulation Requisition Form (Form 15) is mandatory. It is recommended that patient discontinues Heparin for 1 day and Oral Anticoagulants for 7 days prior to sampling as these drugs may affect test results. Discontinuation should be with prior consent from the treating Physician. |
| Test Details | Factor IX is a clotting factor that plays a crucial role in the coagulation cascade. It is a glycoprotein produced in the liver and is essential for the normal blood clotting process. The factor IX functional test is a laboratory test that measures the activity level of factor IX in the blood. This test is used to diagnose and monitor bleeding disorders, such as hemophilia B (also known as Christmas disease), which is characterized by a deficiency or dysfunction of factor IX. During the test, a blood sample is collected from the patient and mixed with a substance that triggers the clotting process. The time it takes for the blood to clot is measured, and the result is compared to a reference range to determine the level of factor IX activity. A normal factor IX activity level is typically between 50% and 150%. If the activity level is below this range, it indicates a deficiency or dysfunction of factor IX, which can lead to excessive bleeding or delayed clotting. The severity of the bleeding disorder can be determined based on the factor IX activity level. The factor IX functional test is usually performed in conjunction with other coagulation tests, such as the prothrombin time (PT) and activated partial thromboplastin time (aPTT), to provide a comprehensive evaluation of the clotting process. In summary, the factor IX functional test measures the activity level of factor IX in the blood and is used to diagnose and monitor bleeding disorders, particularly hemophilia B. |
