PSEN1 Gene (Dementia, Frontotemporal) Genetic Test in UAE – 2800 AED – DNA Labs UAE

Executive Summary & Core Metrics

Comprehensive genetic analysis of the PSEN1 gene for early-onset familial Alzheimer’s disease and frontotemporal dementia, with integrated genetic counseling and ISO-accredited processing. This test delivers 99.9% diagnostic sensitivity via next-generation sequencing (NGS).

Accuracy Guarantee: 99.9% diagnostic sensitivity through ISO-accredited NGS methodology.
Premium Logistics: VIP mobile phlebotomy and temperature-controlled cold-chain home collection available daily 8 AM–11 PM.
Clinical Guidance: Post-test telephonic interpretation by a consultant medical geneticist.
Insurance Support: Direct billing verification via WhatsApp +971 54 548 8731.

Test Overview & Methodology

The PSEN1 Genetic Test provides comprehensive analysis of the presenilin-1 gene, which is strongly associated with early-onset familial Alzheimer’s disease and frontotemporal dementia. Using next-generation sequencing (NGS) at our ISO-certified laboratory, this test detects coding region mutations, deep intronic variants, and copy number variations with exceptional accuracy. The result must be interpreted in the context of clinical and family history by a qualified geneticist.

Feature	Our Test (NGS)	Closest Alternative (Sanger Sequencing)
Precision	Full gene coverage including deep intronic variants	Limited to targeted exons; may miss large deletions
Method	Next-Generation Sequencing (NGS) – Gold Standard	Sanger sequencing – lower throughput
Speed	3 to 4 Weeks	4 to 6 Weeks

Physician Insight & Safety Protocols

“This genetic test reveals crucial information about your risk for inherited dementias, but clinical correlation with a neurologist or genetic counselor is vital. The result is not a standalone diagnosis and must be integrated with your personal and family history.”

— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403

Advisory – Medication and Clinical Safety

Do not discontinue prescribed medication without consulting your physician. The test result does not replace a clinical diagnosis; always discuss findings with your doctor before making any lifestyle or treatment changes.

Exclusion Criteria & Emergency Red Flags

Not recommended for asymptomatic minors without legal guardian consent as per Federal Decree-Law No. 4 of 2016 on Medical Liability.
If you experience sudden cognitive decline, severe confusion, or suicidal thoughts, seek emergency care immediately.
This test is not a substitute for comprehensive neurological evaluation; always discuss results with your physician before any lifestyle or treatment changes.

Patient FAQ & Clinical Guidance

1. What does PSEN1 gene testing for frontotemporal dementia detect?

PSEN1 gene testing by NGS analyzes the entire coding sequence to identify pathogenic mutations linked to early-onset familial Alzheimer’s disease and frontotemporal dementia. It also detects deep intronic variants and copy number changes that may be missed by other methods.

2. How long do results take and how accurate is this test?

Results are available within 3–4 weeks, with analytical sensitivity exceeding 99.9% using next-generation sequencing technology at our ISO-certified laboratory.

3. Is genetic counseling included before and after the test?

Yes, a mandatory genetic counseling session with pedigree analysis is provided to ensure informed consent and accurate interpretation of your results. This is conducted by our consultant medical geneticist.

4. What are the risks of genetic testing for dementia?

Genetic testing may reveal information about your future risk of dementia, which can have psychological and familial implications. Pre- and post-test counseling helps you understand and manage these outcomes.

UAE Regulatory & Data Privacy Adherence

Legal & Regulatory Compliance:

This service adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL).
Clinical testing safety and patient consent follow Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
Patient consent and medical liability practices comply with Federal Decree-Law No. 4 of 2016 on Medical Liability.
Laboratory is ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139).

Clinical & Logistical Metadata

Test Name	PSEN1 Gene (Dementia, Frontotemporal) Genetic Test
Price (AED)	2,800
Turnaround Time	3 to 4 Weeks
Sample Type / Matrix	Peripheral whole blood (EDTA) – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
Methodology Used	Next-Generation Sequencing (NGS) – full gene coverage including intronic regions and CNV analysis
ICD-10-CM Code	G31.0
LOINC Code	69047-9
DHA Facility License & Laboratory Address	DHA Facility License Number: 1143 Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE Corporate Lab: DNA Labs UAE