Test Price
850 AEDโ Home Collection Available
PDGFRA (4q12) Gene Rearrangement FISH Test in Dubai, UAE | DNA Labs UAE
Executive Summary & Core Metrics
- โAccuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 15189 Accredited Molecular Cytogenetics.
- โClinical Utility: Essential for targeted therapy decisions (e.g., Imatinib) in PDGFRA-rearranged leukemias.
- โClinical Logistics: Hospital Extraction Only โ Bone marrow sample collection is conducted strictly within an accredited hospital facility.
- โClinical Oversight: Report signed and interpreted by Consultant Medical Genetics.
- โInsurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
- โMandatory Form: Duly filled Chromosome & FISH Analysis Requisition Form (Form 17) required prior to collection.
Test Overview & Methodology
The PDGFRA (platelet-derived growth factor receptor alpha) gene rearrangement test utilizes Fluorescence In-Situ Hybridization (FISH) to detect pathogenic fusions and deletions at the 4q12 chromosomal locus. A positive result is a defining molecular marker for chronic eosinophilic leukemia (CEL) and identifies patients likely to respond to tyrosine kinase inhibitors (TKIs) such as imatinib mesylate. The assay employs dual-color break-apart probes to reliably detect cryptic rearrangements invisible to conventional karyotyping.
| Feature | PDGFRA FISH (Our Test) | Conventional Karyotype |
|---|---|---|
| Precision | Detects cryptic rearrangements; high specificity & sensitivity | May miss submicroscopic deletions/fusions |
| Methodology | Dual-color break-apart FISH (Molecular Cytogenetics) | G-banded chromosome analysis |
| Turnaround Time | 4 Working Days | 7โ14 Working Days |
Physician Insight & Safety Protocols
"Testing for PDGFRA rearrangements via FISH is a critical step in diagnosing eosinophilic myeloid neoplasms. A positive genetic finding directly informs the use of targeted therapies, potentially altering the disease trajectory. It is imperative, however, to correlate cytogenetic results with peripheral blood morphology, bone marrow histology, and clinical examination to ensure diagnostic accuracy."
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Clinical Advisory & Medication Notice
Do not alter or discontinue any prescribed medication, including tyrosine kinase inhibitors, based solely on the results of this test without direct consultation and interpretation by your supervising hematologist or clinical geneticist. This test is an adjunct to clinical decision-making and must be integrated with the full clinical picture.
Safety Exclusion Criteria & Emergency Indicators
- Hospital Extraction Only: Sample collection is conducted strictly within an accredited hospital facility; mobile home phlebotomy is disabled for safety.
- Coagulopathy Contraindication: Bone marrow aspiration is contraindicated in patients with INR > 1.5, platelet count < 50,000/ยตL, or known bleeding diathesis.
- Transport Stability: Maintain bone marrow aspirate or blood sample at 18โ22ยฐC. Do not freeze. Hemolyzed or clotted samples will be rejected.
- Emergency Red Flags: If you develop severe bleeding, high fever with neutropenia, or new neurological deficits during diagnostic workup, seek immediate emergency medical care.
Patient FAQ & Clinical Guidance
1. What is the PDGFRA gene rearrangement FISH test used for?
This molecular cytogenetic test is used to detect specific genetic abnormalities in the PDGFRA gene located on chromosome 4q12. It plays a crucial role in diagnosing chronic eosinophilic leukemia (CEL) and other myeloproliferative neoplasms with eosinophilia, and in identifying patients who may benefit from targeted therapies such as imatinib.
2. How is the sample collected for this test?
The test requires a bone marrow aspirate or a peripheral blood sample. Bone marrow aspiration is performed by a qualified physician in a hospital setting under sterile conditions. Peripheral blood can be drawn via standard venipuncture at a DNA Labs UAE collection center or a partner hospital.
3. How should I prepare, and what is the turnaround time?
No special preparation like fasting is required. If you are on blood thinners, inform your doctor before the bone marrow procedure. The turnaround time for the final clinical report is 4 working days from the time the sample is received by the laboratory.
UAE Regulatory & Data Privacy Adherence
Data Privacy & Confidentiality: DNA Labs UAE strictly adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic and clinical data are encrypted and handled with the highest degree of confidentiality.
Clinical Safety Framework: All diagnostic procedures are conducted under the ethical and medical liability guidelines set forth by Federal Decree-Law No. 4 of 2016 on Medical Liability.
Accreditation: Our laboratory holds ISO 15189:2022 accreditation for molecular cytogenetic testing, ensuring international standards of quality and competence.
Clinical & Logistical Metadata
| Test Name | PDGFRA (4q12) Gene Rearrangement FISH |
| Price (AED) | 850 |
| Turnaround Time | 4 Working Days |
| Sample Type / Matrix | Bone Marrow Aspirate or Peripheral Whole Blood (Sodium Heparin Green Top) |
| Methodology Used | Dual-Color Break-Apart Fluorescence In-Situ Hybridization (FISH) |
| ICD-10-CM Code | C92.3 (Myeloid sarcoma), D47.8 (Other specified neoplasms of uncertain behavior of lymphoid, hematopoietic and related tissue) |
| LOINC Code | 49492-3 (FISH.w/Probe for Gene Rearrangement in Blood or Marrow) |
| DHA Facility License & Lab Address | DHA License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Corporate Lab: DNA Labs UAE |
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