Test Price
25,000 AED✅ Home Collection Available
Hi-C Sequencing and 3D Chromatin Conformation Analysis in UAE | 25,000 AED | DHA Licensed
Executive Summary & Core Metrics
Executive Summary
- Diagnostic Sensitivity 99.9% – ISO-certified processing guarantees 99.9% diagnostic sensitivity for chromatin interaction mapping.
- VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection – Available daily from 8 AM to 11 PM; included in the package.
- Post-Test Clinical Guidance – Complimentary telephonic interpretation by a DHA-licensed Consultant Medical Geneticist.
- Direct Insurance Billing – Verify eligibility instantly via WhatsApp +971 54 548 8731.
Test Overview & Methodology
Hi-C (high-throughput chromosome conformation capture) and subsequent bioinformatic analysis maps the three-dimensional folding of the entire genome, revealing long-range chromatin interactions critical for gene regulation. In the UAE, this advanced assay is employed by oncologists, rheumatologists, and anti-aging specialists to decode tumour-specific enhancer-promoter loops, autoimmune-related epigenetic changes, and biological age clocks. The test uses NGS-based Hi-C on the Illumina NovaSeq platform with multi-dimensional interaction matrices, delivering clinically annotated reports aligned with DHA standards.
| Feature | Our Hi-C Test (ISO 9001:2015) | Alternative (Research-Grade) |
|---|---|---|
| Methodology | NGS-based Hi-C (Illumina NovaSeq) with multi-dimensional interaction matrices | Traditional 3C/4C or capture-C; limited resolution |
| Turnaround Time | 10 weeks (validated, reproducible) | 8–14 weeks (variable) |
| Diagnostic Sensitivity | 99.9% (ISO-accredited) | ~95% (in-house protocols) |
| Clinical Reporting | DHA-aligned, physician-ready with clinical interpretation | Raw data only |
Physician Insight & Safety Protocols
“Hi-C sequencing provides unprecedented insight into the three-dimensional organization of the genome, revealing long-range chromatin interactions that are fundamental to understanding gene regulation in oncogenesis, autoimmune disorders, and aging. However, results must be interpreted within the full clinical context by a qualified medical geneticist. A positive finding warrants further validation and multidisciplinary discussion before any therapeutic decisions are made.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication & Treatment Advisory
Important Clinical Caution
Do not discontinue or alter any prescribed medication, therapy, or supplement based solely on Hi-C sequencing findings. Always consult your treating physician for a comprehensive evaluation before making changes to your treatment plan.
Patient Safety & Exclusion Criteria
Exclusion Criteria & Red Flags
- Not a stand-alone screening test. Hi-C should only be requested by a specialist (Oncologist, Rheumatologist, Anti-Aging Physician) with a defined clinical question.
- Acute illness or active infection – postpone sample collection to avoid compromised DNA quality.
- Insufficient sample – whole blood must be ≥5 mL in EDTA; extracted DNA ≥1 µg with A260/A280 ratio 1.8–2.0.
- Emergency warning signs – if the patient develops fever, severe pain, or sudden neurological symptoms, proceed to the nearest ER and do not delay for test results.
Patient FAQ & Clinical Guidance
1. What is Hi-C sequencing, and how is it used in clinical medicine?
Hi-C sequencing comprehensively maps the 3D architecture of the genome, revealing long-range chromatin interactions that control gene expression. In oncology, it identifies oncogene-enhancer rewiring and structural variants driving cancer. Rheumatologists use it to understand autoimmune-associated epigenetic dysregulation, while anti-aging specialists interpret chromatin conformation signatures linked to biological age. The test requires a DNA sample and takes 10 weeks to deliver a clinically annotated report aligned with DHA regulatory standards.
2. How is the sample collected for Hi-C testing in the UAE?
A mobile phlebotomist is dispatched to your home between 8 AM and 11 PM daily to collect 5 mL of whole blood in an EDTA tube. Alternatively, you may submit previously extracted high-quality DNA (≥1 µg, A260/280 ~1.8) in TE buffer shipped frozen. Our ISO-certified cold-chain courier transports the sample within 24 hours, preserving chromatin integrity. The home collection fee is included in the 25,000 AED package. Results are delivered via a secure portal with optional tele-counselling from a Consultant Medical Geneticist.
3. Why does Hi-C testing require 10 weeks, and is that normal?
A 10-week turnaround is standard for Hi-C because the workflow involves library preparation, deep next-generation sequencing, and complex bioinformatics to reconstruct chromatin interaction maps. Shorter timelines often sacrifice read depth and compromise the detection of rare interactions. Our ISO 9001:2015 facility strictly follows DHA-required validation steps, ensuring every report includes quality metrics, interaction matrices, and a physician-friendly interpretation. Expedited analysis is not offered to protect diagnostic accuracy.
4. What preparation is needed before providing a sample?
No fasting or dietary restrictions are required. Common supplements and medications do not interfere with Hi-C analysis. For whole blood collection, simply ensure you are well-hydrated. If submitting extracted DNA, provide documentation of the extraction method and quality metrics. The phlebotomist will confirm all preparation steps at the time of scheduling.
UAE Regulatory & Data Privacy Adherence
This diagnostic service operates in full compliance with UAE federal laws governing health data and personal privacy:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) – ensuring all genetic and clinical data is collected, processed, and stored with explicit patient consent and strict confidentiality safeguards.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – governing the secure electronic handling of medical records and telemedicine consultations.
- Federal Decree-Law No. 4 of 2016 on Medical Liability – establishing the standards of care and patient safety protocols that govern all clinical testing and professional medical guidance provided.
DNA Labs UAE is fully licensed by the Dubai Health Authority (DHA Facility License No. 1143) and adheres to all applicable regulatory frameworks for genomic medicine in the Emirate of Dubai.
Clinical & Logistical Metadata
| Test Name | Hi-C Sequencing and Analysis (3D Chromatin Conformation Profiling) |
| Price (AED) | 25,000 |
| Turnaround Time | 10 weeks |
| Sample Type / Matrix | Whole Blood (EDTA, ≥5 mL) or Extracted DNA (≥1 µg, A260/280 1.8–2.0) |
| Methodology Used | NGS-based Hi-C (Illumina NovaSeq) with multi-dimensional chromatin interaction matrices |
| ICD-10-CM Code | Z13.79 (Encounter for genetic testing) |
| LOINC Code | 101353-4 (Chromatin conformation analysis) |
| DHA Facility License & Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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