Test Price
2,800 AED✅ Home Collection Available
CRYBA4 Gene Cataract Type 23 Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين CRYBA4 لإعتام عدسة العين النوع 23 بتقنية التسلسل الجيني من الجيل التالي في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Executive Summary
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing. الدقة التشخيصية 99.9% عبر معالجة حاصلة على شهادة الآيزو
- Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection and VIP Mobile Phlebotomy. خدمة سحب الدم المنزلي بمعايير المستشفيات ونقل مبرد معتمد
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation. إرشاد سريري عبر الهاتف بعد الفحص لتفسير النتائج
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731. التحقق من تغطية التأمين عبر واتساب
Overview
This Next-Generation Sequencing (Genetic Test screens the entire coding region of the CRYBA4 gene to detect pathogenic variants associated with autosomal dominant congenital cataract type 23. It delivers definitive molecular diagnosis with 99.9% analytical sensitivity when performed on blood, extracted DNA, or FTA card samples, supporting personalized surgical and genetic counseling decisions. يقوم هذا الفحص الجيني بتقنية التسلسل من الجيل التالي بمسح كامل لمنطقة التشفير لجين CRYBA4 للكشف عن الطفرات المسببة لإعتام عدسة العين الخلقي النوع 23 بدقة تصل إلى 99.9%.
| Feature | Our Test (CryBA4 NGS) | Standard Sanger Sequencing |
|---|---|---|
| Precision | 99.9% analytical sensitivity & specificity, full gene coverage | ~98% sensitivity, limited to targeted exons only |
| Method | Next-Generation Sequencing (Illumina NovaSeq, verified by Sanger) | Capillary Electrophoresis (Sanger) – lower throughput |
| Speed (TAT) | 3–4 Weeks | 5–6 Weeks |
Physician Insight & Safety Protocol
“As the clinical director overseeing this diagnostic pathway, I emphasize that every CRYBA4 result must be correlated with detailed phenotyping and family history. A positive genetic finding guides early intervention and cascade screening, while a negative result does not rule out other cataract-related genes. Please discuss all results with your ophthalmologist or geneticist before any clinical decision.” — Dr. PRABHAKAR REDDY, DHA License 61713011
⚠️ Medication Warning: Do not discontinue prescribed medication without consulting your doctor. This test does not replace ophthalmic follow-up.
Exclusion Criteria & Emergency Red Flags
- Patients with acute ocular infection or trauma – sample collection deferred.
- Anticoagulation therapy not clinically corrected – risk of hematoma from venipuncture.
- Seek immediate ophthalmic assessment if sudden vision loss, severe eye pain, or acute onset of floaters/flashes occur after sample collection.
- This test is not indicated for acquired cataracts without suspected genetic etiology.
All procedures comply with UAE Federal Decree-Law No. 41 of 2024 (Art. 87), CDS Law 2026 (Minors), and UAE PDPL. ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139).
Patient FAQ & Clinical Guidance
Q1: Why do I need a genetic test for congenital cataract when I already have a clinical diagnosis?
س1: لماذا أحتاج إلى فحص جيني لإعتام عدسة العين الخلقي إذا كان لدي تشخيص سريري بالفعل؟
Identifying the exact CRYBA4 mutation confirms the inheritance pattern, enables accurate genetic counseling for family members, and often guides the timing of cataract surgery in children.
Q2: How is the sample collected, and will it be painful for my child?
س2: كيف يتم جمع العينة وهل ستكون مؤلمة لطفلي؟
A small blood draw (similar to a routine vaccination) or a completely painless cheek swab for DNA extraction is used, performed by our pediatric-trained home collection team within minutes.
Q3: What happens if no mutation is found in the CRYBA4 gene? Does it rule out all risk?
س3: ماذا يحدث إذا لم يتم العثور على طفرة في جين CRYBA4، هل يعني ذلك استبعاد جميع المخاطر؟
A negative result only excludes mutations in this specific gene; your ophthalmologist may recommend broader panel testing or whole-exome sequencing if clinical suspicion remains high.
Pre‑ Requirements
Provide a detailed clinical history including age at cataract onset, laterality, morphologic type. A genetic counseling session to construct a three‑generation pedigree is mandatory before sample submission. For a child, parental consent forms and DHA‑compliant minor assent are required under CDS Law 2026.
Accepted samples: Whole Blood (EDTA), Extracted DNA, or one drop of blood on FTA Card. TAT: 3–4 Weeks.
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
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توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians