DOG-1 Immunohistochemistry Test in UAE | 450 AED | DHA Licensed Lab in Dubai Healthcare City

Executive Summary & Core Metrics

Core Performance Indicators

Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.
Premium Logistics: Secure Medical Courier Solid Tissue Specimen Retrieval for Formalin-Fixed Paraffin-Embedded (FFPE) Blocks and Histopathology Slides.
Clinical Guidance: Telephonic Post-Test Clinical Guidance for comprehensive result interpretation by a Specialist Diagnostic Radiologist.
Insurance & Billing: Direct Billing Verification via WhatsApp +971 54 548 8731.

Test Overview & Methodology

DOG-1 Immunohistochemistry (IHC) is a highly specific tissue-based diagnostic assay that detects the DOG1 protein, a critical biomarker for gastrointestinal stromal tumors (GIST) and other soft-tissue neoplasms. This test provides definitive subtyping to differentiate GIST from morphologically similar tumors, enabling precise targeted therapy decisions. The assay is performed exclusively on archival tissue specimens using validated IHC protocols.

Parameter	DNA Labs UAE DOG-1 IHC Test	Standard Pathology Lab
Methodology	Immunohistochemistry (IHC) with ISO 9001:2015 accredited processing & dual pathologist verification	Standard IHC, often without ISO oversight or dual review
Turnaround Time	5–7 Business Days for archival tissue blocks	7–10 Business Days
Diagnostic Sensitivity	99.9% with expert pathologist review & clinical correlation	Variable, often not quantified
Price (AED)	450	350–450

Physician Insight & Safety Protocols

Mr. Prabhakar Reddy Kalathoor | Specialist Diagnostic Radiology | DHA Registration ID: 61713011 notes: As a specialist in diagnostic radiology and pathology, I emphasize that DOG‑1 IHC, when correlated with clinical history and complementary markers such as CD117, provides a definitive diagnosis for GIST. This enables timely and precisely targeted treatment strategies. A negative result does not entirely exclude malignancy, and further molecular testing may be required. Always discuss your integrated pathology report with your oncologist before making any treatment decisions.

Advisory: Archival Tissue Specimen Handling

To ensure optimal IHC staining quality, the biopsy specimen must be shipped as a formalin-fixed paraffin-embedded (FFPE) block or unstained histopathology slides accompanied by the corresponding histopathology report. Improperly fixed tissue or inadequate tumor material may invalidate the results. This test is classified as an archival tissue retrieval procedure; mobile phlebotomy services are not applicable for this solid tissue matrix.

Exclusion Criteria & Emergency Red Flags

Exclusion: Improperly fixed tissue (not placed immediately in 10% neutral buffered formalin), inadequate tumor material, or missing histopathology report.
Red Flag: If the biopsy specimen is not shipped as a formalin-fixed paraffin-embedded (FFPE) block at room temperature, results may be invalid or significantly delayed.
Red Flag: Onset of severe pain, fever, or uncontrolled bleeding post-biopsy — seek emergency medical care immediately.

Patient FAQ & Clinical Guidance

1. What is the DOG‑1 test used for?

DOG‑1 immunohistochemistry is a diagnostic test that detects the DOG1 protein, primarily used to confirm gastrointestinal stromal tumors (GIST) and differentiate them from other soft tissue sarcomas and spindle cell tumors. It is routinely combined with CD117/c‑KIT staining for accurate tumor subtyping and treatment stratification.

2. What type of sample is required for this test?

This test requires an archival tissue specimen. A formalin-fixed paraffin-embedded (FFPE) tissue block or unstained histopathology slides cut from the block must be submitted along with a copy of the original histopathology report. Blood samples are not acceptable for this solid tissue immunohistochemistry assay.

3. How should I prepare for the DOG‑1 IHC test?

No special patient preparation such as fasting or medication adjustment is required. The tissue sample is collected during a prior surgical or endoscopic biopsy procedure. Simply ensure that your referring physician provides the formalin-fixed tissue block or slides to the laboratory for processing.

4. How long does it take to receive the results?

The turnaround time for DOG‑1 IHC is typically 5 to 7 business days from the time the laboratory receives the specimen. A detailed pathology report interpreting the staining intensity and distribution, along with a clinical recommendation for oncology consultation, will be provided electronically.

UAE Regulatory & Data Privacy Adherence

DNA Labs UAE operates in strict compliance with the UAE's legislative framework for health data protection and medical liability. Patient data is processed and stored in accordance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All clinical testing and patient consent protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. This ensures that your diagnostic information is handled with the highest standards of confidentiality, security, and clinical integrity.

Clinical & Logistical Metadata

Test Name	DOG-1 Immunohistochemistry (IHC)
Price (AED)	450
Turnaround Time	5–7 Business Days
Sample Type / Matrix	Formalin-Fixed Paraffin-Embedded (FFPE) Tissue Block / Histopathology Slides
Methodology Used	Immunohistochemistry (IHC) – ISO 9001:2015 Accredited Processing
ICD-10-CM Code	C49.4 (Malignant neoplasm of connective and soft tissue of abdomen)
LOINC Code	94222-7 (DOG1 [Presence] in Tissue by Immune stain)
DHA Facility License & Address	License No: 1143 \| Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE