Test Price
2,800 AEDโ Home Collection Available
NLRC4 Gene โ Familial Cold Autoinflammatory Syndrome Type 4 Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
This ISO 9001:2015 certified NGS-based genetic test delivers 99.9% diagnostic sensitivity for pathogenic variants in the NLRC4 gene, directly informing the diagnosis of Familial Cold Autoinflammatory Syndrome Type 4 (FCAS4). Our service includes hospital-grade cold-chain home collection, VIP mobile phlebotomy across all Emirates, and telephonic post-test clinical guidance coordinated by DHA-licensed specialists.
Test Overview & Methodology
The NLRC4 Gene NGS Test detects germline and somatic mutations in the NLRC4 gene (2p22.3) associated with Familial Cold Autoinflammatory Syndrome Type 4, a rare hereditary autoinflammatory disorder characterized by cold-induced fevers, urticaria-like rash, and systemic inflammation. Next-Generation Sequencing (NGS) technology enables simultaneous analysis of all coding exons and splice sites with single-nucleotide resolution, providing coverage depth exceeding 100x for confident variant calling. Bioinformatics pipelines aligned to GRCh38/hg38 with ACMG/AMP 2026 classification criteria ensure accurate interpretation.
| Parameter | DNA Labs UAE (DHA-Licensed) | Closest Alternative |
|---|---|---|
| Precision | Single-nucleotide resolution, CNV detection via NGS | Sanger sequencing limited to known hotspots |
| Methodology | NGS with bioinformatics confirmation (100x depth) | Targeted mutation panels with lower coverage |
| Turnaround Time | 3 to 4 Weeks | 6 to 8 Weeks (overseas referral labs) |
| Sample Type | Whole Blood, Extracted DNA, or One Drop Blood on FTA Card | Blood only; no FTA card flexibility |
| Price | 2,800 AED | 3,200โ4,500 AED |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh (DHA Registration ID: 9294403 โ Consultant Medical Genetics) notes: โAs a clinical geneticist who has walked alongside families navigating the uncertainty of autoinflammatory disorders, I understand that pursuing a genetic diagnosis carries both hope and anxiety. This test is a powerful tool, yet it must always be interpreted within the full clinical picture. A positive NLRC4 variant confirms the molecular diagnosis, while a negative result does not exclude the condition if clinical suspicion remains high. I strongly encourage post-test counselling to integrate genomic findings with your personal and family history. Your symptoms are real, your concerns are valid, and we are committed to guiding you through every result with compassion and precision.โ
Advisory: Medication Safety Protocol
Medication Warning: Do not discontinue prescribed medication without consulting your doctor. Abrupt cessation of corticosteroids or biologics may trigger severe disease flares requiring emergency intervention. Always inform our phlebotomist of your current medication list, including immunosuppressants and biologic agents, for accurate test interpretation and safe collection.
Exclusion Criteria & Emergency Red Flags
Exclusion Criteria for At-Home Collection:
- Active febrile episode (temperature >38.5ยฐC) at time of scheduled collection โ reschedule when afebrile for 48 hours.
- Current hospitalization or inpatient status โ requires inpatient phlebotomy per admitting facility protocol.
- Known bleeding diathesis or platelet count <50,000/ยตL without physician clearance for venipuncture.
- Individuals under 18 years without documented guardian consent per UAE Federal Law on medical liability and pediatric care standards.
Emergency Red Flags โ Seek Immediate Medical Attention (Call 998):
- Sudden onset of high fever (>40ยฐC) with confusion or altered consciousness.
- Signs of meningeal irritation: severe headache, neck stiffness, photophobia.
- Acute respiratory distress or stridor with urticarial rash.
- Hemodynamic instability: systolic BP <90 mmHg, tachycardia >120 bpm, or syncope.
- Worsening systemic inflammation unresponsive to prescribed rescue medication.
Patient FAQ & Clinical Guidance
1. What does a positive NLRC4 gene test result mean for my diagnosis and treatment plan?
A positive NLRC4 genetic test result confirms the presence of a pathogenic variant causally linked to Familial Cold Autoinflammatory Syndrome Type 4, enabling your immunologist or dermatologist to tailor targeted anti-IL-1 or anti-IL-18 biologic therapy and establish a personalized long-term monitoring protocol. An indeterminate or variant of uncertain significance (VUS) finding requires correlation with your clinical phenotype and family history; this is not a negative result, and genetic counselling follow-up is essential to reclassify the variant as new evidence emerges. All results are interpreted by DHA-licensed molecular pathologists using 2026 ACMG/AMP variant classification guidelines.
2. How do I prepare for the NLRC4 home blood collection, and is the FTA card option reliable?
Fast from heavy meals for two hours before your scheduled VIP mobile phlebotomy appointment, hydrate adequately with water, and continue all prescribed medications unless your physician has specifically instructed otherwise. The FTA card option is fully validated for NGS workflows โ a single drop of capillary blood from a finger prick is applied to the card, which stabilizes DNA at ambient temperature for transport, eliminating the need for cold-chain logistics while maintaining 99.5% DNA integrity for sequencing. This method is ideal for pediatric patients, individuals with difficult venous access, or remote-area collections across the Emirates. Our ISO 9001:2015 certified laboratory (Cert: INT/EGQ/2509DA/3139) verifies DNA quality upon receipt before initiating sequencing.
3. Is my genetic data protected under UAE law, and who will have access to my NLRC4 results?
Your genetic data is strictly protected under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. These frameworks ensure that only your ordering physician and you receive the results through encrypted, DHA-compliant channels. Data access follows a tiered consent model: the ordering specialist receives the full clinical report; you receive a patient-friendly summary with guidance; and no third party โ including insurers, employers, or family members โ can access your genetic information without explicit written consent. All sequencing data is stored on ISO 27001-certified servers physically located within UAE sovereign data centers, with retention policies compliant with DHA electronic medical record mandates.
UAE Regulatory & Data Privacy Adherence
- โ DHA Facility License Number: 1143 โ Licensed diagnostic laboratory under Dubai Health Authority
- โ ISO 9001:2015 Certified โ Quality Management System (Cert: INT/EGQ/2509DA/3139)
- โ Federal Decree-Law No. 45 of 2021 (PDPL) โ Personal data protection & genetic privacy governance
- โ Federal Law No. 2 of 2019 โ ICT in health fields: secure handling of electronic medical records
- โ Federal Decree-Law No. 4 of 2016 โ Medical liability framework for clinical testing & patient consent
- โ WHO International Patient Safety Goals โ Phlebotomy & specimen handling compliance
- โ Physical Address: Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE
- โ Support & Verification: WhatsApp +971 54 548 8731
Clinical & Logistical Metadata
| Test Name | NLRC4 Gene โ Familial Cold Autoinflammatory Syndrome Type 4 Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Whole Blood, Extracted DNA, or One Drop Blood on FTA Card (VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection) |
| Methodology Used | Next-Generation Sequencing (NGS) with bioinformatics confirmation (100x depth, GRCh38/hg38, ACMG/AMP 2026) |
| ICD-10-CM Code | M04.2 |
| LOINC Code | 21636-6 |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
ุฏุนู ุซูุงุฆู ุงููุบุฉ ู ุชุงุญ
ุงูุชุญูู ู ู ุงูุชุบุทูุฉ ุงูุชุฃู ูููุฉ
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
ุชููู ุนู ุงูุชุฎู ูู. ุฃุฑุณู ุตูุฑุฉ ู ู ุจุทุงูุฉ ุงูุชุฃู ูู ููุตูุฉ ุงูุทุจูุจ ุฅูู ูุฑูู ุงูุชุญูู ุงูู ุนุชู ุฏ ู ู ููุฆุฉ ุงูุตุญุฉ ุจุฏุจู ุนุจุฑ ุงููุงุชุณุงุจ. ุงุญุตู ุนูู ุชุญุฏูุซ ุงูุญุงูุฉ ูู ุฏูุงุฆู.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians