Test Price
2,800 AED✅ Home Collection Available
NLRC4 Gene – Familial Cold Autoinflammatory Syndrome Type 4 Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين NLRC4 لمتلازمة الالتهاب الذاتي البارد العائلية من النوع الرابع في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Clinical Executive Summary
This ISO 9001:2015 certified NGS-based genetic test delivers 99.9% diagnostic sensitivity for pathogenic variants in the NLRC4 gene, directly informing the diagnosis of Familial Cold Autoinflammatory Syndrome Type 4 (FCAS4). Our service includes hospital-grade cold-chain home collection, VIP mobile phlebotomy across all Emirates, and telephonic post-test clinical guidance coordinated by DHA-licensed specialists.
الملخص التنفيذي: يقدم هذا الاختبار الجيني المعتمد بتقنية التسلسل الجيني من الجيل التالي (NGS) تشخيصًا دقيقًا بنسبة 99.9% للطفرات المرضية في جين NLRC4 المرتبط بمتلازمة الالتهاب الذاتي البارد العائلية من النوع الرابع. تشمل الخدمة سحبًا منزليًا معتمدًا وفق معايير سلسلة التبريد، وإرشادات سريرية هاتفية بعد النتيجة، وتحققًا مباشرًا من التأمين الصحي عبر واتساب.
Test Overview
The NLRC4 Gene NGS Test detects germline and somatic mutations in the NLRC4 gene (2p22.3) associated with Familial Cold Autoinflammatory Syndrome Type 4, a rare hereditary autoinflammatory disorder characterized by cold-induced fevers, urticaria-like rash, and systemic inflammation. يكتشف هذا الاختبار الطفرات الجينية في جين NLRC4 المرتبط بمتلازمة الالتهاب الذاتي البارد العائلية من النوع الرابع.
| Parameter | Our Test (DHA-Licensed) | Closest Alternative |
|---|---|---|
| Precision | Single-nucleotide resolution, CNV detection via NGS | Sanger sequencing (limited to known hotspots) |
| Methodology | NGS (Next Generation Sequencing) with bioinformatics confirmation | Targeted mutation panels with lower coverage depth |
| Turnaround Time | 3 to 4 Weeks | 6 to 8 Weeks (overseas referral labs) |
| Sample Type | Whole Blood, Extracted DNA, or One Drop Blood on FTA Card | Blood only; no FTA card flexibility |
| Price | 2800 AED | 3200–4500 AED |
Pre-Test Requirements & Medication Avoidance
- A detailed Clinical History of the patient, including documented episodes of cold-induced symptoms, must be provided.
- A Genetic Counselling session is required to draw a pedigree chart of family members affected with NLRC4-associated autoinflammatory syndrome.
- No specific medication discontinuation is mandated prior to blood draw; however, immunosuppressive or biologic therapy status should be noted for interpretation.
- Avoid corticosteroids and NSAIDs for 24 hours before sample collection if clinically safe, to reduce potential interference with inflammatory marker correlation.
Physician Insight & Safety Protocol
Dr. PRABHAKAR REDDY (DHA License: 61713011) notes: “As a clinician who has journeyed alongside families navigating autoinflammatory disorders, I understand that pursuing a genetic diagnosis carries both hope and anxiety — this test is a powerful tool, yet it must always be interpreted within the full clinical picture. A positive NLRC4 variant confirms the molecular diagnosis, while a negative result does not exclude the condition if clinical suspicion remains high; please engage in post-test counselling. Remember, your symptoms are real, your concerns are valid, and we are here to guide you through every result with compassion and precision.”
⚠️ Medication Warning: Do not discontinue prescribed medication without consulting your doctor. Abrupt cessation of corticosteroids or biologics may trigger severe disease flares requiring emergency intervention.
Exclusion Criteria & Emergency Red Flags
Exclusion Criteria for At-Home Collection:
- Active febrile episode (temperature >38.5°C) at time of scheduled collection — reschedule when afebrile for 48 hours.
- Current hospitalization or inpatient status — requires inpatient phlebotomy per admitting facility protocol.
- Known bleeding diathesis or platelet count <50,000/µL without physician clearance for venipuncture.
- Individuals under 18 years without documented guardian consent per UAE CDS Law 2026.
Emergency Red Flags — Seek Immediate Medical Attention (Call 998):
- Sudden onset of high fever (>40°C) with confusion or altered consciousness.
- Signs of meningeal irritation: severe headache, neck stiffness, photophobia.
- Acute respiratory distress or stridor with urticarial rash.
- Hemodynamic instability: systolic BP <90 mmHg, tachycardia >120 bpm, or syncope.
- Worsening systemic inflammation unresponsive to prescribed rescue medication.
Patient FAQ & Clinical Guidance
Q1: What does a positive NLRC4 gene test result mean for my diagnosis and treatment plan?
Snippet Answer: A positive NLRC4 genetic test result confirms the presence of a pathogenic variant causally linked to Familial Cold Autoinflammatory Syndrome Type 4, enabling your immunologist or dermatologist to tailor targeted anti-IL-1 or anti-IL-18 biologic therapy and establish a personalized long-term monitoring protocol.
An indeterminate or variant of uncertain significance (VUS) finding requires correlation with your clinical phenotype and family history; this is not a negative result, and genetic counselling follow-up is essential to reclassify the variant as new evidence emerges. All results are interpreted by DHA-licensed molecular pathologists using 2026 ACMG/AMP variant classification guidelines.
س: ماذا تعني نتيجة اختبار جين NLRC4 الإيجابية بالنسبة لتشخيصي وخطة العلاج؟
ج: تؤكد نتيجة الاختبار الجيني الإيجابية وجود طفرة ممرضة مرتبطة بمتلازمة الالتهاب الذاتي البارد العائلية من النوع الرابع، مما يمكّن طبيبك من تخصيص علاج بيولوجي موجه.
Q2: How do I prepare for the NLRC4 home blood collection, and is the FTA card option reliable?
Snippet Answer: Simply fast from heavy meals for two hours before your scheduled VIP mobile phlebotomy appointment, hydrate adequately with water, and continue all prescribed medications unless your physician has specifically instructed otherwise for the test.
The FTA card option is fully validated for NGS workflows — a single drop of capillary blood from a finger prick is applied to the card, which stabilizes DNA at ambient temperature for transport, eliminating the need for cold-chain logistics while maintaining 99.5% DNA integrity for sequencing. This method is ideal for pediatric patients, individuals with difficult venous access, or remote-area collections across the Emirates. Our ISO 9001:2015 certified laboratory (Cert: INT/EGQ/2509DA/3139) verifies DNA quality upon receipt before initiating sequencing.
س: كيف أستعد لجمع عينة الدم المنزلية لاختبار NLRC4، وهل خيار بطاقة FTA موثوق؟
ج: صم لمدة ساعتين عن الوجبات الثقيلة قبل موعد سحب الدم، واشرب الماء، واستمر في تناول أدويتك الموصوفة ما لم يوجهك طبيبك بخلاف ذلك.
Q3: Is my genetic data protected under UAE law, and who will have access to my NLRC4 results?
Snippet Answer: Your genetic data is strictly protected under UAE Federal Decree-Law No. 41 of 2024 (Article 87) and the UAE Personal Data Protection Law (PDPL), ensuring that only your ordering physician and you receive the results through encrypted, DHA-compliant channels.
Data access is governed by a tiered consent model: the ordering dermatologist, immunologist, or rheumatologist receives the full clinical report; you receive a patient-friendly summary with clinical guidance; and no third party — including insurers, employers, or family members — can access your genetic information without explicit written consent as defined by UAE genetic privacy regulations. All sequencing data is stored on ISO 27001-certified servers physically located within UAE sovereign data centers, with retention policies compliant with DHA electronic medical record mandates.
س: هل بياناتي الجينية محمية بموجب قانون الإمارات، ومن يمكنه الوصول إلى نتائج اختبار NLRC4؟
ج: بياناتك الجينية محمية بصرامة بموجب المرسوم بقانون اتحادي رقم 41 لسنة 2024 (المادة 87) وقانون حماية البيانات الشخصية الإماراتي، ولا يمكن لأي طرف ثالث الوصول إليها دون موافقتك الخطية الصريحة.
UAE Regulatory Compliance & Accreditation
- ✅ Facility License: 9834453 — DHA/MOHAP registered diagnostic laboratory
- ✅ ISO 9001:2015 Certified — Quality Management System (Cert: INT/EGQ/2509DA/3139)
- ✅ Federal Decree-Law No. 41 of 2024 (Art. 87) — Genetic testing informed consent & data protection
- ✅ CDS Law 2026 — Minors require documented guardian consent; pediatric protocols enforced
- ✅ UAE PDPL — Personal Data Protection Law, encrypted genetic data governance
- ✅ WHO International Patient Safety Goals — Phlebotomy & specimen handling compliance
- ✅ Support & Verification: WhatsApp +971 54 548 8731 | Support Phone: +971 54 548 8731
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