ITGAM Gene Systemic Lupus Erythematosus Susceptibility Genetic Test in UAE | 2800 AED | DHA Regulated

ISO 9001:2015 Certified • DHA Regulated

Executive Summary & Core Metrics

✅ Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited NGS Processing.

🚑 Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection — Available daily from 8 AM to 11 PM.

📋 Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by our clinical genetics team.

💳 Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.

Test Overview & Methodology

This advanced genetic test sequences the ITGAM gene using Next-Generation Sequencing (NGS) to detect both common and rare variants that confer elevated risk for systemic lupus erythematosus (SLE). The analysis covers all coding exons, splice sites, and flanking intronic regions to ensure comprehensive variant discovery. Results support early risk stratification, family cascade screening, and personalized preventive care planning in coordination with a rheumatologist and clinical geneticist.

Aspect	Our NGS Test (ITGAM)	Closest Alternative (PCR SNP Genotyping)
Detection Scope	All coding regions, splice sites, rare and novel variants	Only pre-defined common SNPs (limited coverage)
Analytical Sensitivity	99.9%	~85–90% for targeted positions
Turnaround Time	3 – 4 Weeks	2 – 3 Weeks
Clinical Utility	Comprehensive risk profiling; suitable for family screening	Basic risk assessment; may miss rare pathogenic variants

Physician Insight & Safety Protocols

“The ITGAM gene encodes the integrin alpha M subunit, a key component of the complement receptor 3 pathway implicated in immune complex clearance. A comprehensive NGS-based analysis of this gene provides valuable risk information for systemic lupus erythematosus susceptibility, but the result must never be interpreted in isolation. I strongly recommend combining genetic findings with clinical autoantibody profiling and a formal rheumatological assessment before making any changes to surveillance or treatment plans. Pre-test and post-test genetic counselling are essential components of responsible testing.” — Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403

⛔ Medication Advisory

Do not discontinue or alter prescribed immunomodulatory therapy (e.g., hydroxychloroquine, corticosteroids, or immunosuppressants) based solely on this genetic test result. Abrupt medication changes can precipitate severe disease exacerbations. Always consult your treating rheumatologist or physician before making any therapeutic adjustments.

🛑 Safety Exclusion Criteria & ER Red Flags

This test is not indicated for minors without legal guardian consent as defined under Federal Decree-Law No. 4 of 2016 on Medical Liability; a court-appointed guardian must provide written authorization for pediatric genetic testing.
If you experience acute chest pain, severe shortness of breath, sudden vision loss, or seizures, proceed to the nearest emergency department immediately — these may indicate active lupus involvement requiring urgent medical attention.
Patients with active infections or recent blood transfusions should wait 4 weeks before sample collection (please consult our clinical team for guidance).
Test results must be correlated with clinical findings; a negative result does not exclude SLE if symptoms persist.

Patient FAQ & Clinical Guidance

1. How does the ITGAM NGS test help in lupus risk assessment?

This test sequences the entire ITGAM gene to detect rare and common variants that significantly raise the lifetime risk of developing systemic lupus erythematosus, enabling early surveillance and personalised prevention strategies. Results are interpreted by a multidisciplinary team including rheumatologists and clinical geneticists to guide further immunological workup.

2. What is the turnaround time and is pre-test counselling required?

Results are available within 3 to 4 weeks from sample receipt. A mandatory pre-test genetic counselling session is required to document family history, construct a pedigree chart, and obtain informed consent. Post-test counselling is also provided to explain the implications of your result and coordinate appropriate follow-up with a specialist.

3. Can I use my insurance and request home collection?

Yes, we offer direct insurance billing verification — simply send your policy details via WhatsApp to +971 54 548 8731 and our team will confirm coverage within 2 hours. Home collection by a DHA-licensed phlebotomist is available daily from 8 AM to 11 PM, with temperature-controlled cold-chain transport to our ISO-certified laboratory.

UAE Regulatory & Data Privacy Adherence

Regulatory Compliance: This service operates in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic sequence data is encrypted, stored within UAE sovereign infrastructure, and never shared with third parties without explicit written consent. Our laboratory holds ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139) and is licensed by the Dubai Health Authority under facility license number 1143. For clinical inquiries, call or WhatsApp +971 54 548 8731.

Clinical & Logistical Metadata

Test Name	ITGAM Gene Systemic Lupus Erythematosus Susceptibility Genetic Test
Price (AED)	2,800
Turnaround Time	3 – 4 Weeks
Sample Type / Matrix	Peripheral Whole Blood (EDTA) — Home collection available daily 8 AM – 11 PM via VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Logistics
Methodology Used	Next-Generation Sequencing (NGS) – Full Gene Coding Region, Splice Sites, and Flanking Intronic Analysis
ICD-10-CM Code	M32.9, Z15.89, Z13.0
LOINC Code	93505-4
DHA Facility License & Laboratory Address	DHA Facility License Number: 1143 \| DNA Labs UAE \| Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE

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