Test Price
2,800 AED✅ Home Collection Available
Purkinje Cell Cytoplasmic Antibody Type Tr (DNER) Autoantibody Test in the UAE | AED 2800 | DNA Labs UAE
Executive Summary & Core Metrics
Gold‑standard detection for paraneoplastic cerebellar degeneration via Cell‑Based Indirect Immunofluorescence (CBA‑IFA).
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified Processing.
- Specimen Collection: Hospital Extraction Only – Sample collection is conducted strictly within an accredited hospital facility; mobile home phlebotomy is disabled for safety.
- Clinical Guidance: Complimentary Telephonic Post‑Test Result Interpretation with a Specialist.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The Purkinje Cell Cytoplasmic Antibody Type Tr (DNER) test identifies autoantibodies against the Delta/Notch‑like EGF‑related receptor (DNER) enriched on cerebellar Purkinje neurons. This specific biomarker is primarily associated with paraneoplastic cerebellar degeneration, most frequently linked to Hodgkin lymphoma. The laboratory method employs Cell‑Based Indirect Immunofluorescence (CBA‑IFA) using recombinant DNER‑expressing cells and primate cerebellum substrate for highest specificity.
| Parameter | Our Test (ISO Lab) | Closest Alternative |
|---|---|---|
| Methodology | Cell‑Based Indirect Immunofluorescence (CBA‑IFA) with primate cerebellum substrate | Commercial line blot / ELISA |
| Diagnostic Specificity | >99% for anti‑DNER (confirmed by recombinant DNER cell assay) | 85‑92% (may miss conformational epitopes) |
| Turnaround Time | 3 weeks (send‑out to reference lab) | 1‑2 weeks local processing |
| Sample Types | Serum (red‑top) & CSF (sterile container) – Hospital extraction only | Serum only |
Physician Insight & Safety Protocols
Advisory: Medication Continuation
⛔ Medication Warning
Do not discontinue prescribed medication without consulting your doctor. Abrupt withdrawal may exacerbate neurological symptoms or mask underlying disease activity.
Exclusion Criteria & Emergency Red Flags
Critical Safety Information
- Exclusion Criteria: Recent intravenous immunoglobulin (IVIg), plasmapheresis, or high‑dose immunosuppressants (within 4 weeks) may cause false‑negative results. Severe hemolysis or lipemia can interfere with immunofluorescence.
- ER Red Flags: If you experience sudden loss of balance, new‑onset double vision, difficulty swallowing, or seizures, seek emergency medical attention immediately.
Patient FAQ & Clinical Guidance
1. What does a positive anti‑DNER antibody result mean?
A positive result indicates an autoimmune attack on Purkinje cells, often linked to paraneoplastic cerebellar degeneration, typically associated with Hodgkin lymphoma. Results should be evaluated together with comprehensive neurological and imaging examinations.
2. How should I prepare for the Purkinje Cell Antibody Type Tr test?
Overnight fasting (8–12 hours) is preferred. A signed Test Send Out Consent Form (Form 35) is mandatory. For serum sample use a plain red‑top tube (3 mL, minimum 2 mL) – do not use SST gel barrier tubes. For CSF sample use a sterile screw‑capped container (2 mL, minimum 1 mL). Note: Both sample collections are performed exclusively in a hospital setting.
3. Why is this test priced at AED 2800 and takes 3 weeks?
The test uses specialized cell‑based immunofluorescence and requires send‑out to a reference lab, ensuring high specificity and accurate correlation. The price covers temperature‑controlled transport, expert technician processing, and comprehensive interpretative reporting.
UAE Regulatory & Data Privacy Adherence
Data Privacy: Compliant with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
Quality Management: ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139).
Licensing: DHA Facility License No. 1143 – Laboratory services regulated by Dubai Health Authority.
Clinical & Logistical Metadata
| Test Name | Purkinje Cell Cytoplasmic Antibody Type Tr (DNER) Autoantibody Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3 weeks (send‑out to reference lab) |
| Sample Type / Matrix | Hospital Extraction Only – Sample collection is conducted strictly within an accredited hospital facility; mobile home phlebotomy is disabled for safety. Specimens: Serum (red‑top tube) and CSF (sterile container). |
| Methodology Used | Cell‑Based Indirect Immunofluorescence (CBA‑IFA) with recombinant DNER cell assay and primate cerebellum substrate |
| ICD-10-CM Code | G13.0 (Paraneoplastic neuromyopathy and neuropathy) |
| LOINC Code | 48753-2 (Purkinje cell antibody type Tr [Presence] in Serum) |
| DHA Facility License & Laboratory Address | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DHA License No: 1143 | DNA Labs UAE |
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