Test Price
220 AEDโ Home Collection Available
ANCA (Antineutrophil Cytoplasmic Antibodies) IFA Test in UAE | 220 AED
Executive Summary & Core Metrics
The ANCA IFA test is a high-sensitivity screening immunofluorescence assay that detects autoantibodies against neutrophil cytoplasmic antigens. This test is essential for diagnosing and monitoring ANCA-associated vasculitides, including granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA).
- Diagnostic Accuracy: 99.9% sensitivity via ISO 9001:2015 accredited processing with gold-standard IFA pattern recognition.
- Collection Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Post-Test Support: Telephonic result interpretation by a DHA-licensed General Practitioner.
- Insurance Verification: Direct billing confirmation via WhatsApp +971 54 548 8731.
Test Overview & Methodology
Indirect Immunofluorescence Assay (IFA) on ethanol-fixed and formalin-fixed human neutrophils remains the gold-standard screening method for ANCA detection. The assay differentiates cytoplasmic (c-ANCA) and perinuclear (p-ANCA) staining patterns, providing critical diagnostic orientation before antigen-specific confirmatory testing for MPO and PR3 antibodies.
| Feature | DNA Labs UAE โ ANCA IFA | Alternative โ ANCA ELISA |
|---|---|---|
| Screening Breadth | Detects all ANCA subtypes including atypical patterns via visual fluorescence microscopy | Restricted to predefined MPO and PR3 antigens; may miss rare or atypical ANCA |
| Methodological Gold Standard | Indirect Immunofluorescence Assay (IFA) โ internationally recommended first-line screen | Enzyme-Linked Immunosorbent Assay (ELISA) โ reserved for confirmatory antigen specificity |
| Turnaround Time | Same-day result when sample arrives by 11 AM | Next-day or extended turnaround typical |
Physician Insight & Safety Protocols
Dr. Ajay Singh (DHA Registration ID: 36234132), General Practitioner at DNA Labs UAE, advises: โA positive ANCA result must always be interpreted within the full clinical picture including renal function, inflammatory markers, and imaging findings. The IFA pattern guides the diagnostic pathway, but antigen-specific ELISA confirmation and specialist rheumatology or nephrology consultation are indispensable before initiating immunosuppressive therapy.โ
Clinical Advisory
โ ๏ธ Diagnostic Guidance: This ANCA IFA test is a screening and diagnostic aid. Do not alter or discontinue any prescribed medication without direct consultation with your treating physician. Results must be correlated with clinical evaluation and additional laboratory parameters.
Exclusion Criteria & Emergency Indicators
Pre-Test Considerations & Urgent Warning Signs
- Exclusion for Sample Integrity: Inform the laboratory if you have received immunoglobulin therapy or plasma exchange within the past 8 weeks, as these interventions may interfere with antibody detection accuracy.
- Emergency Red Flags: Seek immediate emergency care if you experience sudden vision loss, severe unremitting headache, hemoptysis (coughing up blood), or acutely reduced urine output โ these may signal a severe vasculitis flare requiring urgent hospital management.
- Minor Consent Protocol: In accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability, individuals under 18 years must present with a legal guardian holding a valid Emirates ID for sample collection consent.
Patient FAQ & Clinical Guidance
1. What is the ANCA IFA test and when is it prescribed?
The ANCA IFA test detects autoantibodies directed against neutrophil cytoplasmic components. Physicians order this test when patients present with unexplained renal impairment, pulmonary hemorrhage, chronic sinusitis, mononeuritis multiplex, or other systemic symptoms concerning for ANCA-associated vasculitis such as granulomatosis with polyangiitis, microscopic polyangiitis, or eosinophilic granulomatosis with polyangiitis.
2. How should I prepare for the ANCA blood draw?
Overnight fasting (8โ12 hours) is recommended for optimal serum clarity. You may drink plain water. Continue all prescribed medications unless explicitly instructed otherwise by your doctor. Inform the phlebotomist if you have undergone plasma exchange or received immunoglobulin therapy within the preceding 8 weeks.
3. What does a positive c-ANCA or p-ANCA pattern mean?
A cytoplasmic (c-ANCA) pattern typically correlates with anti-PR3 antibodies and is strongly associated with granulomatosis with polyangiitis. A perinuclear (p-ANCA) pattern often corresponds to anti-MPO antibodies and is linked to microscopic polyangiitis and eosinophilic granulomatosis with polyangiitis. However, IFA patterns are orientation-only; confirmatory antigen-specific ELISA testing is required for definitive classification.
4. What is the turnaround time for results?
When your blood sample reaches the DNA Labs UAE facility by 11 AM, results are processed and reported on the same day. Standard turnaround is 24โ48 hours for samples arriving later. Reports are delivered digitally and can be discussed via telephonic consultation with our DHA-licensed physician.
5. Can I have my blood drawn at home?
Yes. DNA Labs UAE offers VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection daily between 8 AM and 11 PM. A certified phlebotomist visits your residence, and the specimen is transported under rigorous cold-chain conditions to preserve serum integrity for accurate IFA analysis.
UAE Regulatory & Data Privacy Adherence
All laboratory testing performed by DNA Labs UAE strictly complies with:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) โ ensuring full confidentiality of your medical records and test results.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields โ governing secure electronic health data exchange and telemedicine frameworks.
- Federal Decree-Law No. 4 of 2016 on Medical Liability โ regulating clinical safety, patient consent protocols, and professional accountability.
Our diagnostic services operate under DHA Facility License No. 1143 and adhere to ISO 9001:2015 quality management standards.
Clinical & Logistical Metadata
| Test Name | ANCA (Antineutrophil Cytoplasmic Antibodies) IFA Test |
| Price (AED) | 220 |
| Turnaround Time | Same-day (sample by 11 AM) / 24โ48 hours standard |
| Sample Type / Matrix | Serum (peripheral whole blood) |
| Methodology Used | Indirect Immunofluorescence Assay (IFA) on ethanol and formalin-fixed neutrophils |
| ICD-10-CM Code | M31.30 |
| LOINC Code | 24541-4 |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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