Test Price
750 AED✅ Home Collection Available
ANCA Panel with Auto-Reflex to MPO & PR3 – 750 AED
Executive Summary & Core Metrics
- ✓ Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139). Dual-platform verification with IIF and ELISA ensures clinical-grade reliability.
- ✓ Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM across all Emirates.
- ✓ Clinical Guidance: Complimentary telephonic post-test clinical guidance for result interpretation by qualified laboratory consultants.
- ✓ Insurance: Direct billing verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The ANCA (Anti-Neutrophil Cytoplasmic Antibodies) Panel with automatic reflex to MPO and PR3 is a high-specificity autoimmune diagnostic test designed to detect and differentiate vasculitides including Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangiitis (MPA). This reflex protocol ensures that any positive ANCA screen is automatically confirmed and subtyped without requiring a second blood draw, reducing diagnostic delay and patient burden.
| Feature | Our Test – ANCA with Reflex | Closest Alternative – Standalone ANCA |
|---|---|---|
| Precision | Dual-platform: IIF + ELISA reflex for MPO & PR3 | Single-platform IIF only; no automated subtyping |
| Methodology | Indirect Immunofluorescence + ELISA/EIA quantification | Indirect Immunofluorescence only |
| Turnaround | Next-day reporting by 6 PM | 3–5 business days; reflex requires second visit |
| ISO Accreditation | ISO 9001:2015 (INT/EGQ/2509DA/3139) | Variable; often unaccredited |
| Price | 750 AED (all-inclusive reflex) | 600–900 AED (plus additional charges for reflex) |
Physician Insight & Safety Protocols
Dr. Ajay Singh
General Practitioner | DHA Registration ID: 36234132
"As a general practitioner experienced in managing autoimmune conditions, I understand the anxiety that accompanies vasculitis testing. The ANCA panel with reflex is a reliable tool, but results must always be interpreted alongside clinical findings and other lab markers. Always consult your rheumatologist for a comprehensive diagnosis and treatment plan."
Medication Warning
Do not discontinue any prescribed medication, including corticosteroids, immunosuppressants, or any other treatment regimen, without consulting your doctor. Abrupt cessation of immunosuppressive therapy may trigger disease flare or adrenal insufficiency.
Safety Exclusion Criteria & Emergency Red Flags
Exclusion Criteria
- Active severe systemic infection or sepsis contraindicating elective phlebotomy.
- Hemodynamic instability (systolic BP < 90 mmHg) precluding safe venous access.
- Known severe coagulopathy or platelet count < 30,000/µL without physician clearance.
- Inability to provide informed consent per Federal Decree-Law No. 4 of 2016 on Medical Liability.
ER Red Flags – Seek Immediate Care
- Acute hemoptysis (coughing up blood) or sudden breathlessness.
- Rapidly progressive kidney injury (oliguria, facial or pedal edema).
- Severe mononeuritis multiplex or acute foot/wrist drop.
- Palpable purpura with necrosis or digital ischemia.
If you experience any of the above symptoms, proceed to the nearest Emergency Department immediately. These results are for diagnostic support only and do not replace urgent clinical assessment.
Patient FAQ & Clinical Guidance
1. What is the ANCA with Reflex to MPO & PR3 test and why is it ordered?
The ANCA with Reflex to MPO & PR3 test detects anti-neutrophil cytoplasmic antibodies and automatically reflexes positive screens to MPO and PR3 antibody assays for precise vasculitis subtyping and disease monitoring. This test is primarily ordered when a physician suspects systemic autoimmune vasculitis—conditions where the body's immune system mistakenly attacks its own small blood vessels. Clinical indications include unexplained multisystem symptoms such as persistent sinusitis, pulmonary infiltrates, hemoptysis, rapidly progressive glomerulonephritis, palpable purpura, mononeuritis multiplex, or constitutional symptoms like fever of unknown origin and unintentional weight loss. The reflex protocol is critical because distinguishing between c-ANCA (typically PR3-associated, seen in Granulomatosis with Polyangiitis) and p-ANCA (typically MPO-associated, seen in Microscopic Polyangiitis and Eosinophilic Granulomatosis with Polyangiitis) directly influences treatment strategy and prognosis.
2. Why is overnight fasting preferred before the ANCA blood draw?
Overnight fasting is preferred to reduce lipemic interference in serum samples, which can obscure indirect immunofluorescence pattern interpretation and compromise ELISA optical density readings for accurate ANCA and MPO/PR3 quantification. Postprandial lipemia—elevated chylomicrons and very-low-density lipoproteins after a meal—causes light scattering in immunofluorescence microscopy and matrix effects in enzyme immunoassays. This can lead to false-negative or indeterminate results, particularly in borderline-positive cases where subtle perinuclear (p-ANCA) or cytoplasmic (c-ANCA) staining patterns must be distinguished. Fasting for 8–12 hours (water is permitted) ensures optimal sample integrity. Patients on chronic medications should take them as prescribed with a sip of water unless specifically instructed otherwise by their physician.
3. How quickly will I receive my ANCA test results in the UAE?
ANCA test results are reported by 6 PM the next day when samples are collected on Monday, Wednesday, or Friday mornings before 9 AM through our ISO-certified laboratory with DHA license 1143. The testing workflow follows a sequential protocol: upon arrival, serum is separated and subjected to indirect immunofluorescence on ethanol-fixed neutrophil substrates. If the ANCA screen is positive, the sample is automatically reflexed to MPO-IgG and PR3-IgG ELISA assays on the same day. Results are validated by a clinical pathologist and released through our secure online portal with optional WhatsApp notification. For urgent clinical scenarios, expedited same-day reporting may be available upon physician request. Our home collection service operates 8 AM – 11 PM daily, and results can be discussed during a complimentary telephonic consultation.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance & Data Privacy
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL): Patient data is encrypted, stored within UAE sovereign data centers, and never shared without explicit consent.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields: All electronic health data handling complies with mandated security standards.
- Federal Decree-Law No. 4 of 2016 on Medical Liability: Patient consent and safety protocols adhere to this law.
- DHA Facility License: 1143 | ISO 9001:2015 Certification: INT/EGQ/2509DA/3139.
Clinical & Logistical Metadata
| Test Name | ANCA Panel with Auto-Reflex to MPO & PR3 |
| Price (AED) | 750 |
| Turnaround Time | 1 business day (by 6 PM next day) |
| Sample Type / Matrix | Serum |
| Methodology Used | Indirect Immunofluorescence (IIF) + Enzyme-Linked Immunosorbent Assay (ELISA) |
| ICD-10-CM Code | M31.3 |
| LOINC Code | 98731-4 |
| DHA Facility License & Address | DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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