Test Price
40,000 AEDโ Home Collection Available
Amyloid Protein Identification Test in UAE | 40000 AED | DHA Licensed Laboratory
Executive Summary & Core Metrics
Definitive Proteomic Subtyping for Amyloidosis
This advanced histopathology assay employs laser capture microdissection coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS) to identify the precise amyloid protein subtype deposited in tissue. Accurate differentiation of AL, ATTR, and rare hereditary forms is essential for directing targeted therapy. The test is performed under ISO 9001:2015 accreditation using archival formalin-fixed paraffin-embedded (FFPE) tissue blocks. The price of 40000 AED includes secure medical courier solid tissue specimen retrieval, the full proteomic analysis, and a telephonic post-test clinical guidance session with a qualified specialist.
99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing, utilizing gold-standard LC-MS/MS proteomic analysis for precise amyloid subtyping across more than 20 known variants.
Secure Medical Courier Solid Tissue Specimen Retrieval for pre-existing FFPE blocks. Temperature-controlled chain of custody ensures sample integrity from referring laboratory to our facility.
Telephonic Post-Test Clinical Guidance by a qualified specialist to interpret your Amyloid Typing results and correlate with clinical findings.
Direct Billing Verification & Pre-Approval Assistance via WhatsApp: +971 54 548 8731
Test Overview & Methodology
The Amyloid Protein Identification Test is the definitive, proteomics-based assay for subtyping amyloid deposits in formalin-fixed paraffin-embedded (FFPE) tissue biopsies. In the UAE, this test is pivotal for differentiating AL amyloidosis from ATTR and other rare hereditary forms, directly guiding targeted chemotherapy, immunotherapy, or stabilizer therapy. The methodology employs laser capture microdissection to isolate amyloid-rich areas, followed by tryptic digestion and LC-MS/MS analysis to identify the causative protein with high specificity.
| Feature | Our Test | Closest Alternative (IHC) |
|---|---|---|
| Precision | Direct protein sequencing; identifies >20 amyloid subtypes. | Antibody-based; limited by availability and cross-reactivity. |
| Methodology | Laser Capture Microdissection + LC-MS/MS. | Immunohistochemistry (IHC) staining. |
| Turnaround Time | 2-3 weeks from monthly batch submission (sample cutoff 7th of month). | 5-7 days. |
| Regulatory Status | DHA/MOHAP Referral, ISO 9001:2015 Certified, fully compliant with UAE health data regulations. | Routine Pathology Accreditation. |
Physician Insight & Safety Protocols
Dr. Prabhakar Reddy Kalathoor (Specialist Diagnostic Radiology, DHA ID: 61713011): "Amyloidosis is a master of disguise. A precise proteomic diagnosis via LC-MS/MS is not just a testโit is the critical fork in the road between prescribing plasma-cell directed chemotherapy for AL amyloidosis or a transthyretin stabilizer for ATTR. I strongly advise clinical correlation with cardiology and nephrology findings."
Advisory & Safety Precautions
Important Medication Advisory
Do not discontinue any prescribed medication, including amyloid-modifying therapies, without explicit instruction from your treating physician. This test is a diagnostic aid and does not replace ongoing clinical management.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Inadequate FFPE tissue with less than 10% amyloid deposition on Congo Red stain.
- Exclusion: Missing mandatory Form 35 (Test Send Out Consent) or original histopathology report.
- Exclusion: Samples not received by the 7th of the calendar month.
- Emergency Red Flag: If you experience severe chest pain, acute breathlessness, or sudden syncope, proceed directly to the Emergency Department. Do not wait for test results.
- Data Privacy: All proteomic data is managed under UAE Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL).
Patient FAQ & Clinical Guidance
1. Why is specialized LC-MS/MS necessary when a standard biopsy already confirmed amyloidosis?
A standard biopsy with Congo Red stain confirms the presence of amyloid deposits, but only direct proteomic identification accurately differentiates between the over 20 amyloid-causing proteins. Determining whether you have AL amyloidosis (light chain) or ATTR amyloidosis (transthyretin) is essential, as treatment strategies are fundamentally different: chemotherapy for AL versus gene-silencing drugs or stabilizers for ATTR.
2. The report mentions a monthly processing cycle. What does this mean for my sample timeline?
Your FFPE block must arrive by the 7th of the month to be included in the concurrent batch, with results reported approximately 2 to 3 weeks after the batch processing date. This specialized laboratory calendar is designed to maintain the highest quality mass spectrometry calibration and proteomic data integrity for accurate subtyping.
3. Is the 40000 AED cost covered by insurance, and how do I arrange logistics?
The 40000 AED fee is typically covered under advanced pathology benefits, and our team provides direct insurance pre-approval verification via WhatsApp to minimize out-of-pocket surprises. We coordinate secure medical courier retrieval of your pre-existing FFPE block from the referring histopathology laboratory, ensuring essential cold-chain custody and mandatory documentation transfer.
UAE Regulatory & Data Privacy Adherence
Our laboratory operates in full compliance with UAE health and data protection laws:
- Data Protection: Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Health Information Technology: Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Medical Liability & Patient Consent: Federal Decree-Law No. 4 of 2016 on Medical Liability ensures all testing is conducted with informed consent and professional accountability.
- Accreditation: ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139).
This service adheres to DHA/MOHAP standard nomenclature for amyloid typing and relevant clinical guidelines.
Clinical & Logistical Metadata
| Test Name | Amyloid Protein Identification (LC-MS/MS) |
| Price (AED) | 40,000 AED |
| Turnaround Time | 2-3 weeks from monthly batch submission (sample cutoff: 7th of month) |
| Sample Type / Matrix | Formalin-Fixed Paraffin-Embedded (FFPE) Tissue Block |
| Methodology Used | Laser Capture Microdissection + Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) |
| ICD-10-CM Code | E85.9 (Amyloidosis, unspecified) |
| LOINC Code | 94122-7 (Amyloid protein identification in Tissue by Liquid chromatography-tandem mass spectrometry) |
| DHA Facility License & Laboratory Address | DHA Facility License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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All reports reviewed by DHA-Certified physicians