Test Price
1,100 AED✅ Home Collection Available
Hydroxyproline Plasma Test in UAE | 1100 AED | DHA Licensed Laboratory
Executive Summary & Core Metrics
Test Overview & Methodology
Hydroxyproline is a non-proteogenic amino acid integral to collagen structure; its plasma level aids in diagnosing inborn errors of metabolism such as hyperhydroxyprolinemia and assessing collagen turnover. This test employs isotope-dilution liquid chromatography-tandem mass spectrometry (LC-MS/MS), delivering exceptional analytical specificity and sensitivity for precise quantification.
| Feature | Our Test (LC-MS/MS) | Closest Alternative (HPLC-Ion Exchange) |
|---|---|---|
| Precision | Isotope dilution MS; CV <3% | Post-column ninhydrin; CV ~10% |
| Methodology | LC-MS/MS (DHA-Recommended) | Ion-Exchange Chromatography |
| Speed (TAT) | 3 working days | 5-7 working days |
| Sample Stability | Cold-chain home collection, refrigerated/frozen | Often requires in-lab immediate processing |
Physician Insight & Safety Protocols
"The LC-MS/MS method for plasma hydroxyproline offers a level of analytical precision that is essential for reliably detecting subtle alterations in collagen metabolism. However, results must always be contextualised within the patient's full clinical history, dietary intake, and growth parameters. Laboratory data complements—but never replaces—comprehensive medical evaluation."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory & Pre-Test Requirements
⚠️ Critical Medication Warning
Do not discontinue prescribed medication without consulting your doctor. Certain collagen supplements or high-dose vitamin C may transiently alter hydroxyproline levels; inform your physician of all supplements before testing.
Exclusion Criteria & Emergency Indicators
- Exclusion: Active febrile illness within 24 hours; recent trauma or surgery (within 2 weeks) due to altered collagen metabolism.
- Exclusion: Non-compliance with overnight fasting (except pediatric patients where non-fasting sample is acceptable per DHA guidelines).
- ER Red Flag: If the test was ordered due to suspected metabolic crisis and the patient exhibits acute vomiting, lethargy, or hyperammonemia, seek immediate emergency care.
- Pediatric Safety: For minors, collection must adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring parental consent and supervised phlebotomy.
Patient FAQ & Clinical Guidance
1. What is the Hydroxyproline Plasma test used for?
This test helps screen for inborn errors of collagen metabolism and monitor therapeutic response in gelatin-based or anti-aging protocols. The LC-MS/MS method ensures high specificity for accurate clinical decision-making.
2. What does a high Hydroxyproline level indicate?
Elevated hydroxyproline often reflects increased collagen breakdown, possibly from metabolic bone disease, rapid growth, or hyperhydroxyprolinemia. Correlation with the full clinical picture is essential before drawing conclusions.
3. Can I get this test done at home in the UAE?
Yes, VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection is available across all Emirates daily from 8 AM to 11 PM. A trained phlebotomist will collect the sample under strict cold-chain logistics.
UAE Regulatory & Data Privacy Adherence
This test is performed under the regulatory oversight of the Dubai Health Authority (DHA) and complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All patient data is encrypted and stored in compliance with UAE federal health data governance standards. Clinical safety and patient consent procedures follow Federal Decree-Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | Hydroxyproline Plasma Test |
| Price (AED) | 1100 AED |
| Turnaround Time | 3 working days |
| Sample Type / Matrix | 2 mL (1 mL min.) plasma from 1 Green Top (Sodium Heparin) tube. Separate plasma into sterile screw capped vial. Ship refrigerated or frozen. Overnight fasting mandatory; non-fasting acceptable for pediatric patients. |
| Methodology Used | Isotope-Dilution Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) |
| ICD-10-CM Code | E72.5 (Disorder of glycine metabolism) |
| LOINC Code | 14633-5 |
| DHA Facility License & Laboratory Address | DHA Facility License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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