Test Price
2,800 AED✅ Home Collection Available
MMP20 Gene Amelogenesis Imperfecta Type IIA2 (Hypomaturation) Genetic Test in UAE | AED 2,800 | DHA Licensed
Executive Summary & Core Metrics
- ✓ 99.9% Diagnostic Sensitivity via ISO-Accredited Next-Generation Sequencing (NGS) covering the entire MMP20 coding region and splice sites.
- ✓ VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection – Available daily from 8 AM to 11 PM for peripheral whole blood, dried blood spot, or extracted DNA samples.
- ✓ Post-Test Clinical Guidance – Complimentary telephonic result interpretation with a DHA-licensed clinical geneticist.
- ✓ Direct Billing Verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The MMP20 Gene Amelogenesis Imperfecta Type IIA2 NGS test identifies pathogenic variants in the MMP20 gene responsible for hypomaturation-type amelogenesis imperfecta (AI2A2). This DHA-endorsed assay is essential for accurate diagnosis, familial genetic counseling, and personalized dental management in the UAE. Our laboratory employs full-gene next-generation sequencing to deliver comprehensive variant coverage with greater than 99.9 percent sensitivity.
| Feature | Our MMP20 NGS Test | Alternative Test (Targeted PCR/Sanger) |
|---|---|---|
| Technology | Full-gene Next-Generation Sequencing (NGS) | Limited hotspot Sanger sequencing |
| Variant Coverage | Entire coding region plus splice sites (greater than 99.9 percent sensitivity) | Pre-selected known mutations only (approximately 95 percent sensitivity) |
| Turnaround Time | 3 to 4 weeks | 5 to 6 weeks |
| Regulatory Compliance | DHA-licensed, ISO 9001:2015, UAE PDPL | May lack local accreditation |
| Digital Report | Yes – secure patient portal with encrypted PDF delivery | Variable |
Physician Insight & Safety Protocols
“A positive MMP20 test confirms hypomaturation-type AI2A2, yet clinical correlation with the dental phenotype and comprehensive family history remains crucial. A negative result does not rule out the diagnosis when clinical suspicion is elevated. All findings should be discussed with your dentist or a board-certified clinical geneticist.”
– Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Medication Advisory & Pretreatment Guidance
Do not alter or discontinue any prescribed medications, including topical fluoride regimens or dental restorative protocols, without prior consultation with your treating clinician. Genetic test results provide diagnostic clarity but do not replace ongoing clinical evaluation by your dental specialist.
A mandatory pre-test genetic counselling session is required to construct a detailed family pedigree and obtain informed consent in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability. This session ensures that all patients and guardians understand the scope, limitations, and implications of genetic testing for hereditary dental conditions.
Safety & Exclusion Criteria
- Exclusion: Individuals who are unable to provide informed consent. Minors must have consent from a parent or legal guardian as required by UAE Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Exclusion: Active dental or systemic infection that requires immediate intervention – sample collection should be postponed until the acute episode resolves.
- Emergency Red Flag: Severe tooth pain, facial swelling, fever, or difficulty breathing necessitates immediate emergency dental or medical attention. Do not delay care while awaiting genetic test results.
- Pre-Test Requirement: A dedicated genetic counselling session to document a three-generation family pedigree is mandatory prior to sample submission.
Patient FAQ & Clinical Guidance
1. What is the MMP20 gene test and why do I need it?
The MMP20 gene test detects mutations that cause hypomaturation-type amelogenesis imperfecta (type IIA2). Identifying the specific genetic variant confirms the diagnosis, helps your dental team predict disease progression, select appropriate restorative materials, and plan long-term oral care. It also enables accurate family screening and genetic counselling for at-risk relatives.
2. How is the test performed and what sample is required?
A licensed mobile phlebotomist collects either a peripheral venous blood sample (EDTA tube) or a single dried blood spot on an FTA card. Both methods are minimally invasive and stable during temperature-controlled transport. Genomic DNA is extracted and analysed using next-generation sequencing with comprehensive bioinformatic alignment to reference sequences.
3. How long do results take and how will I receive them?
Results are typically available within 3 to 4 weeks from sample receipt. The final report is double-validated by a clinical genomicist and delivered as an encrypted PDF via our secure patient portal. A DHA-licensed genetic counsellor will schedule a complimentary telephonic session to explain the findings, discuss clinical implications, and outline next steps for dental management and family screening.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance Framework
This genetic testing service strictly adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All sample handling, data processing, and reporting meet ISO 9001:2015 quality management standards (Cert: INT/EGQ/2509DA/3139). Patient confidentiality and clinical safety are prioritised throughout the testing lifecycle.
Clinical & Logistical Metadata
| Test Name | MMP20 Gene Amelogenesis Imperfecta Type IIA2 (Hypomaturation) Genetic Test |
| Price (AED) | AED 2,800 |
| Turnaround Time | 3 to 4 weeks from sample receipt |
| Sample Type / Matrix | Peripheral whole blood (EDTA), extracted genomic DNA, or dried blood spot (FTA card) |
| Methodology Used | Next-Generation Sequencing (NGS) – full-gene coverage including coding exons and splice junctions |
| ICD-10-CM Code | K00.5 |
| LOINC Code | 79031-9 |
| DHA Facility License & Laboratory Address | DHA License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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التحقق من التغطية التأمينية
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All reports reviewed by DHA-Certified physicians