ADAM10 Gene Alzheimer Disease Type 18 Susceptibility – Genetic Test in UAE | 2800 AED

Executive Summary & Core Metrics

✓Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 accredited processing (Cert: INT/EGQ/2509DA/3139).
✓Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (daily 8 AM – 11 PM).
✓Clinical Guidance: Telephonic post-test consultation with a certified genetic counsellor for result interpretation.
✓Insurance: Direct billing verification via WhatsApp +971 54 548 8731.

Test Overview & Methodology

The ADAM10 genetic test identifies inherited mutations that significantly increase the risk of early-onset Alzheimer disease type 18 (AD18). Our NGS methodology comprehensively sequences the entire gene, detecting single nucleotide variants, deletions, and duplications – enabling precise genetic counselling and proactive health management.

Feature	Our Test – ADAM10 NGS	Closest Alternative (Single-Gene Sanger)
Method	Illumina NovaSeq 6000 Next-Generation Sequencing	Capillary Sanger Sequencing of selected exons
Coverage	Full gene (coding & flanking intronic regions, CNV analysis)	Limited to known hotspot regions only
Turnaround Time	3–4 Weeks	2–3 Weeks (but misses novel/rare variants)
Diagnostic Yield	>99.9% for ADAM10-related mutations	<60% (incomplete gene analysis)

Physician Insight & Safety Protocols

“This test provides valuable risk information for families with known or suspected ADAM10 mutations. Results must be correlated with clinical presentation, cognitive assessment, and family history. A pathogenic variant does not confirm disease onset but warrants informed surveillance and future-planning discussions.”

— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403

Advisory & Safety Notices

This test is intended for predictive risk assessment only. It does not diagnose or rule out current Alzheimer disease. Clinical decisions must be made by a qualified neurologist or geriatrician. If you experience sudden confusion, expressive aphasia, or severe neurological deficits, seek emergency care immediately.

Pre-Test Exclusion Criteria (Federal Decree-Law No. 4 of 2016 on Medical Liability)

Age below 18 years (mandatory genetic testing restrictions for minors).
Inability to provide valid informed consent (legally authorised guardian required if applicable).
Active systemic infection/febrile illness that may interfere with phlebotomy.

Patient FAQ & Clinical Guidance

1. What does the ADAM10 genetic test detect and who should consider it?

This NGS test identifies pathogenic variants in the ADAM10 gene linked to autosomal dominant Alzheimer disease type 18, enabling accurate risk assessment for individuals with a strong family history of early-onset dementia.

2. How is the sample collected and what logistics apply in the UAE?

We provide a VIP mobile phlebotomy service between 8 AM – 11 PM daily; a single blood draw is transported in an ISO cold chain to our accredited laboratory, with results returned in 3–4 weeks.

3. Are the results covered by insurance and how are they interpreted?

Direct billing verification is available through our WhatsApp support; a telephonic post-test consultation with a clinical genetic counsellor explains risk interpretation, limitations, and next steps.

4. Can a negative result rule out Alzheimer disease entirely?

No. A negative result reduces but does not eliminate risk. Many genetic and environmental factors contribute to Alzheimer disease. This test only evaluates one specific gene; other causes should be considered if clinical suspicion remains.

5. How long does it take to receive results?

Results are typically available within 3–4 weeks from sample receipt. You will be notified by email or phone and a counselling session will be scheduled.

UAE Regulatory & Data Privacy Adherence

Data Protection Compliance: All genetic and personal data are processed and stored in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Laboratory operations adhere to ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) and DHA licensing requirements.

Clinical & Logistical Metadata

Test Name	ADAM10 Gene Alzheimer Disease Type 18 Susceptibility (NGS)
Price (AED)	2,800 AED
Turnaround Time	3–4 Weeks
Sample Type / Matrix	Peripheral Whole Blood
Methodology Used	Next-Generation Sequencing (Illumina NovaSeq 6000)
ICD-10-CM Code	G30.0, Z15.89, Z82.0
LOINC Code	101523-5
DHA Facility License & Laboratory Address	DHA License: 1143 \| DNA Labs UAE, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE

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