COL4A4 Gene Alport Syndrome (Autosomal Recessive) Genetic Test in UAE | 2800 AED | DHA Licensed

Executive Summary & Core Metrics

✓Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
✓Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily 8 AM to 11 PM.
✓Clinical Guidance: Telephonic Post-Test Clinical Guidance for result interpretation and counselling.
✓Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.

Test Overview & Methodology

The COL4A4 Gene Alport Syndrome (Autosomal Recessive) NGS Test identifies pathogenic variants in the COL4A4 gene causing autosomal recessive Alport syndrome, a progressive kidney disease with hearing and vision involvement. Our test delivers clinical-grade precision using full-gene sequencing and comprehensive reporting aligned with international standards.

Feature	Our Test (COL4A4 NGS)	Closest Alternative (Sanger Sequencing)
Precision / Coverage	Full gene sequencing – all exons and splice sites	Single‑exon or targeted mutation analysis only
Methodology	Next Generation Sequencing (Illumina NovaSeq)	Sanger sequencing
Turnaround Time	3 to 4 Weeks	6 to 8 Weeks
UAE Regulatory Compliance	Full – ISO 9001:2015, PDPL	Variable

Physician Insight & Safety Protocols

“As a DHA‑licensed Consultant Medical Geneticist, I emphasize that a positive COL4A4 mutation requires comprehensive clinical correlation with renal function, audiometry, and family history. Genetic results are a key piece of the diagnostic puzzle but should be interpreted alongside clinical findings. I encourage post-test genetic counselling for all patients.” — Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA: 9294403)

Medication Advisory

Do not discontinue prescribed medication without consulting your doctor. This test provides genetic information only and does not alter acute treatment protocols.

Exclusion Criteria & Emergency Red Flags

Testing of minors without parental/legal guardian consent (in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability).
Asymptomatic individuals without a confirmed family history or a prior genetic counselling session.
This test is not a substitute for renal biopsy, ophthalmologic examination, or audiological assessment.

ER Red Flags – seek immediate medical attention if the patient experiences:

Sudden hearing loss or tinnitus.
Oliguria (low urine output) or anuria.
Severe flank pain with fever.
Rapid weight gain from edema.

Patient FAQ & Clinical Guidance

1. What is the COL4A4 gene Alport syndrome test?

This NGS test identifies genetic variants in COL4A4 responsible for autosomal recessive Alport syndrome affecting the kidneys, ears, and eyes. It confirms the diagnosis at a molecular level, aids in family risk assessment, and guides monitoring for extra-renal complications.

2. Who should consider this test in the UAE?

Individuals with unexplained hematuria, hearing loss, or family history of Alport syndrome require genetic confirmation for optimal management. The test is equally indicated for potential carriers in consanguineous families, a common presentation in the region.

3. How accurate is the test and what does it cost?

Our NGS offers >99.9% analytical sensitivity and specificity at 2800 AED with home collection and 3-4 week TAT. The price covers the full gene sequencing, genetic counselling online session, and a detailed clinical report aligned with DHA standards.

UAE Regulatory & Data Privacy Adherence

Regulatory Compliance Framework

This test is conducted in compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient data is encrypted, anonymized, and stored in UAE-based servers.

Clinical safety and patient consent procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Our facility is DHA-licensed and ISO 9001:2015 certified.

Clinical & Logistical Metadata

Test Name	COL4A4 Gene Alport Syndrome (Autosomal Recessive) Genetic Test
Price (AED)	2,800 AED
Turnaround Time	3 to 4 Weeks
Sample Type / Matrix	Peripheral Whole Blood – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
Methodology Used	Next Generation Sequencing (NGS) – full gene sequencing (Illumina NovaSeq)
ICD-10-CM Code	Q87.81
LOINC Code	82187-8
DHA Facility License & Laboratory Address Invariants	Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE \| License #1143