Test Price
2,200 AED✅ Home Collection Available
Pregnenolone Test in UAE | 2200 AED | 2026 DHA Guidelines
تحليل البريغنينولون في الإمارات | 2200 درهم | معتمد من هيئة الصحة بدبي
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited LC‑MS/MS Processing.
- Premium Logistics: ISO Certified Cold‑Chain Home Collection & VIP Mobile Phlebotomy (AED 2200 all‑inclusive).
- Clinical Guidance: Telephonic Post‑Test Clinical Guidance by a DHA‑licensed endocrinologist.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview
Pregnenolone is the master precursor hormone produced in the adrenal glands and central nervous system. This highly sensitive test quantifies serum pregnenolone using LC‑MS/MS to aid in the diagnosis of congenital adrenal hyperplasia (CAH) and monitor hormone replacement or anti‑aging protocols under specialist supervision.
يُعتبر البريغنينولون الهرمون الأساسي السليفي الذي يُصنع في الغدد الكظرية. يقيس هذا التحليل تركيزه في المصل بأعلى مستويات الخصوصية، مما يساعد أطباء الغدد الصماء وأخصائيي مكافحة الشيخوخة في تشخيص فرط التنسج الكظري الخلقي وتقييم مسارات الستيرويدات.
| Parameter | Pregnenolone (Our Lab – DHA/MOHAP) | Immunoassay (Alternate Labs) |
|---|---|---|
| Methodology | LC‑MS/MS (Gold Standard) | ELISA / CLIA |
| Analytical Specificity | >99% – no cross‑reactivity | Moderate, possible steroid cross‑reactivity |
| Precision (CV%) | <5% | 10–15% |
| Sample Volume | 1 mL serum (Red Top tube) | Often 0.5–1 mL serum |
| Turnaround Time | 2–3 weeks (send‑out batch) | 3–5 days (in‑house) |
Physician Insight & Safety Protocol
“Pregnenolone is a critical neurosteroid and adrenal precursor; its measurement by LC‑MS/MS offers unrivalled specificity that guides targeted interventions in congenital adrenal hyperplasia and functional endocrinology. I always correlate results with the full clinical picture – symptoms, cortisol pathway metabolites, and genetic testing when indicated – because a single hormone value never tells the whole story.”
— Dr. Prabhakar Reddy, DHA License No. 61713011 (Consultant Endocrinologist)
⚠ Important Safety Notice
Do not discontinue any prescribed medication (especially corticosteroids or hormone therapy) without explicit instruction from your treating physician. Abrupt cessation can precipitate adrenal crisis.
Exclusion Criteria & Red Flags:
- Recent steroid use: Testing within 24–48 hours of exogenous glucocorticoid administration may distort results; discuss with your doctor.
- Acute illness or severe stress: Postpone the test if you are febrile, hypotensive, or recovering from surgery, as adrenal output fluctuates.
- Pregnancy: Pregnenolone levels are physiologically altered; interpret only under maternal‑fetal medicine guidance.
- Emergency red flags: If you experience severe dizziness, confusion, vomiting, or extreme weakness before or after the test, seek emergency care immediately – these could indicate adrenal insufficiency or crisis.
Patient FAQ & Clinical Guidance
What is pregnenolone and why is this test performed?
Direct Answer: This test measures pregnenolone levels to assess adrenal gland function and detect congenital adrenal hyperplasia. Pregnenolone is the first key steroid synthesized from cholesterol in the adrenal cortex; it serves as a precursor to all downstream hormones like cortisol, DHEA, and estrogens. Endocrinologists order it when they suspect enzyme deficiencies (e.g., 21‑hydroxylase deficiency) or when monitoring anti‑aging hormone optimization protocols. The LC‑MS/MS method eliminates interference from similar molecules, ensuring accurate diagnosis.
يقيس هذا التحليل مستوى البريغنينولون لتقييم وظيفة الغدة الكظرية واكتشاف فرط التنسج الكظري الخلقي بدقة. وهو أول هرمون ستيرويدي يُصنع من الكوليسترول في قشرة الكظر، ويستخدمه الأطباء لتشخيص عوز الإنزيمات ومراقبة بروتوكولات مكافحة الشيخوخة.
How should I prepare for the Pregnenolone test?
Direct Answer: Fasting is not needed, but avoid steroid medications for 24 hours prior to blood draw. Use a plain red top tube (no gel separator). Ship the sample refrigerated or frozen. If you are taking hormone therapy (glucocorticoids, DHEA, or pregnenolone supplements), your doctor will advise whether to withhold them before the collection. A mandatory Send Out Consent Form (Form 35) must be completed.
لا يُشترط الصيام، ولكن يجب تجنب أدوية الستيرويد لمدة 24 ساعة قبل سحب الدم. يُستخدم أنبوب أحمر عادي (بدون جل فاصل) ويُرسل العينة مبردة أو مجمدة مع نموذج الموافقة الإلزامي (Form 35).
What do abnormal pregnenolone results indicate?
Direct Answer: Elevated pregnenolone may suggest congenital adrenal hyperplasia, enzyme deficiency, or adrenal tumor requiring endocrinologist evaluation. Low levels can be seen in adrenal insufficiency or with certain genetic defects. Because pregnenolone sits early in the steroidogenic pathway, it must be interpreted alongside cortisol, 17‑OH progesterone, and DHEA to pinpoint the metabolic block. Your specialist will decide if genetic testing or imaging is needed.
ارتفاع البريغنينولون قد يشير إلى فرط التنسج الكظري الخلقي أو عوز إنزيمي أو ورم كظري، ويستدعي تقييم أخصائي الغدد الصماء. أما انخفاضه فيمكن أن يترافق مع قصور الكظر. يجب أن يُقرأ التحليل ضمن لوحة كاملة من الستيرويدات.
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