Test Price
2,200 AED✅ Home Collection Available
Pregnenolone Test in Dubai – LC‑MS/MS | Premium Diagnostics by DNA Labs UAE
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited LC‑MS/MS Processing.
- Premium Logistics: ISO Certified Cold‑Chain Home Collection & VIP Mobile Phlebotomy (AED 2,200 all‑inclusive).
- Clinical Guidance: Telephonic Post‑Test Clinical Guidance by a DHA‑licensed General Practitioner.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
Pregnenolone is the master precursor hormone synthesised in the adrenal glands and central nervous system. This highly sensitive test quantifies serum pregnenolone using Liquid Chromatography‑Tandem Mass Spectrometry (LC‑MS/MS) to aid in the diagnosis of congenital adrenal hyperplasia (CAH), adrenal insufficiency, and to monitor hormone replacement or anti‑aging protocols under specialist supervision. The assay eliminates cross‑reactivity from structurally similar steroids, providing unrivalled analytical specificity.
| Parameter | DNA Labs UAE (DHA Licensed – LC‑MS/MS) | Immunoassay (Alternate Labs) |
|---|---|---|
| Methodology | LC‑MS/MS (Gold Standard) | ELISA / CLIA |
| Analytical Specificity | >99% – no cross‑reactivity | Moderate; possible steroid cross‑reactivity |
| Precision (CV%) | <5% | 10–15% |
| Sample Volume | 1 mL serum (Red Top tube – no gel) | 0.5–1 mL serum or plasma |
| Turnaround Time | 2–3 weeks (send‑out batch, ISO cold‑chain) | 3–5 days (in‑house) |
Physician Insight & Safety Protocols
“As a General Practitioner, I frequently encounter patients presenting with fatigue, mood disturbances, or unexplained hormonal symptoms. The pregnenolone test measured by LC‑MS/MS offers precise quantification of this master precursor, enabling early identification of adrenal dysfunction. However, results must always be interpreted within the full clinical picture – including cortisol, DHEA, and 17‑OH progesterone – and never lead to self‑adjustment of hormone therapies. Always consult your specialist before making any changes.”
— Dr. Ajay Singh, DHA License No. 36234132 (General Practitioner)
Safety Protocol & Clinical Guidance
⚠ Important Safety Notice
Do not discontinue any prescribed medication (especially corticosteroids, DHEA, or hormone replacement therapy) without explicit instruction from your treating physician. Abrupt cessation can precipitate adrenal crisis or hormone imbalance.
- Fasting not required – but avoid exogenous steroids for 24 hours prior to collection (discuss with your doctor).
- Sample requirement: 1 mL serum in a plain red top tube (no gel separator). Ship refrigerated or frozen.
- Consent: A mandatory Send Out Consent Form (Form 35) must be completed prior to collection.
- Emergency red flags: If you experience severe dizziness, confusion, vomiting, or extreme weakness before or after the test, seek emergency care immediately – these could indicate adrenal insufficiency or crisis.
Patient Exclusion Criteria
The following conditions may invalidate results or pose health risks:
- Recent steroid use: Testing within 24–48 hours of exogenous glucocorticoid administration may distort results; discuss with your doctor.
- Acute illness or severe stress: Postpone the test if you are febrile, hypotensive, or recovering from surgery, as adrenal output fluctuates.
- Pregnancy: Pregnenolone levels are physiologically altered; interpret only under maternal‑fetal medicine guidance.
- History of adrenal insufficiency or crisis: Only proceed under direct supervision of an endocrinologist.
Patient FAQ & Clinical Guidance
1. What is pregnenolone and why is this test performed?
Answer: This test measures pregnenolone levels to evaluate adrenal gland function, detect congenital adrenal hyperplasia, and monitor hormone replacement or anti‑aging protocols. Pregnenolone is the first key steroid synthesised from cholesterol in the adrenal cortex; it serves as a precursor to all downstream hormones like cortisol, DHEA, and estrogens. The LC‑MS/MS method eliminates interference from similar molecules, ensuring accurate diagnosis.
2. How should I prepare for the Pregnenolone test?
Answer: Fasting is not needed. Avoid steroid medications for 24 hours prior to blood draw (consult your doctor). Use a plain red top tube (no gel separator). Ship the sample refrigerated or frozen. A mandatory Send Out Consent Form (Form 35) must be completed. If you are taking hormone therapy (glucocorticoids, DHEA, or pregnenolone supplements), your doctor will advise whether to withhold them before collection.
3. What do abnormal pregnenolone results indicate?
Answer: Elevated pregnenolone may suggest congenital adrenal hyperplasia, enzyme deficiency (e.g., 21‑hydroxylase), or adrenal tumour requiring endocrinologist evaluation. Low levels can be seen in adrenal insufficiency or with certain genetic defects. Because pregnenolone sits early in the steroidogenic pathway, it must be interpreted alongside cortisol, 17‑OH progesterone, and DHEA to pinpoint the metabolic block. Your specialist will decide if genetic testing or imaging is needed.
UAE Regulatory & Data Privacy Adherence
🔒 Data Protection & Legal Compliance
- All personal health data is processed in strict compliance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Clinical testing safety and patient consent adhere to Federal Decree‑Law No. 4 of 2016 on Medical Liability.
- This facility operates under DHA License No. 1143 and follows all Dubai Healthcare City Authority regulations.
- Results are transmitted via encrypted channels; physical reports are delivered in sealed envelopes. No third‑party sharing without your explicit consent.
Clinical & Logistical Metadata
| Test Name | Pregnenolone, Serum |
| Price (AED) | 2,200 AED (all‑inclusive, home collection) |
| Turnaround Time | 2–3 weeks (send‑out batch, ISO cold‑chain courier) |
| Sample Type / Matrix | Serum (1 mL, Red Top tube – no gel separator) |
| Methodology Used | LC‑MS/MS (Liquid Chromatography‑Tandem Mass Spectrometry) – Gold Standard |
| ICD-10-CM Code | E27.9 (Adrenal disorder, unspecified) – Use for test indication |
| LOINC Code | 2092-8 (Pregnenolone [Mass/volume] in Serum or Plasma) |
| DHA Facility License & Laboratory Address | DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Lab: DNA Labs UAE |
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