Symptoms and Testing information for AML FISH PANEL FISH AMLETO inv16 PMLRARA MLL Test

Symptoms and Testing information for AML FISH PANEL FISH AMLETO inv16 PMLRARA MLL Test


Acute Myeloid Leukemia (AML) is a fast-progressing form of cancer of the blood and bone marrow. AML is characterized by the overproduction of immature white blood cells, known as myeloblasts or leukemic blasts. These cells crowd out normal cells, leading to serious health problems such as anemia, infection, and bleeding. In order to accurately diagnose and categorize AML, specific genetic tests are conducted. One such test is the AML FISH (Fluorescence In Situ Hybridization) Panel, which includes the FISH AMLETO inv16, PMLRARA, and MLL tests. This panel is crucial for determining the genetic abnormalities associated with AML, thereby guiding treatment decisions.

The cost of the AML FISH Panel test at DNA Labs UAE is 2970 AED. This comprehensive testing approach is vital for the effective management and treatment of AML.

For more information, please visit DNA Labs UAE.

Understanding the Symptoms

Recognizing the symptoms of AML can be challenging, as they are often vague and not specific. However, certain signs should prompt individuals to seek medical evaluation, which might lead to genetic testing, including the AML FISH Panel. Some of these symptoms include:

  • Fever and night sweats
  • Fatigue and weakness
  • Shortness of breath
  • Pale skin
  • Frequent infections
  • Bruising or bleeding easily
  • Weight loss
  • Bone or joint pain

It is important to note that these symptoms can be caused by a wide range of other health conditions. Therefore, a thorough evaluation by a healthcare professional, including specific genetic tests like the AML FISH Panel, is essential for an accurate diagnosis.

Significance of the AML FISH Panel

The AML FISH Panel is a targeted genetic test that looks for specific chromosomal abnormalities associated with AML. This panel includes tests for inv16, PMLRARA, and MLL rearrangements. These genetic markers are crucial for diagnosing certain subtypes of AML, understanding the prognosis, and determining the most effective treatment strategies. Here’s a brief overview of each component:

  • inv16: This test detects the inversion of chromosome 16, which is associated with a subtype of AML that generally has a good response to certain treatments.
  • PMLRARA: This test identifies the presence of the PML-RARA fusion gene, which is indicative of Acute Promyelocytic Leukemia (APL), a subtype of AML. APL is particularly responsive to all-trans retinoic acid (ATRA) as part of the treatment regimen.
  • MLL: This test looks for rearrangements of the MLL gene, which can be found in various subtypes of AML and is important for prognosis and treatment planning.

The AML FISH Panel provides essential genetic information that helps in tailoring the most effective treatment plans for patients with AML, thereby significantly impacting their overall prognosis and quality of life.


AML is a complex disease that requires precise diagnostic tools for effective management. The AML FISH Panel, including the FISH AMLETO inv16, PMLRARA, and MLL tests, plays a pivotal role in the diagnosis and treatment of AML by identifying key genetic abnormalities. Recognizing the symptoms of AML and undergoing timely genetic testing can lead to better treatment outcomes. With a cost of 2970 AED, DNA Labs UAE provides this crucial testing service, supporting patients and healthcare providers in the fight against AML.

For detailed information and to access this test, visit DNA Labs UAE.

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