Dubin-Johnson Syndrome (DJS) is a rare genetic disorder characterized by chronic jaundice. This condition arises due to a mutation in the ABCC2 gene, which plays a crucial role in the secretion of conjugated bilirubin from hepatocytes into the bile. The ABCC2 gene Dubin-Johnson Syndrome Genetic Test is a pivotal step towards diagnosing this condition, enabling individuals to manage their symptoms effectively and improve their quality of life. DNA Labs UAE offers this genetic test, providing a comprehensive analysis for those suspected of having DJS.
Symptoms of Dubin-Johnson Syndrome
Dubin-Johnson Syndrome manifests primarily through jaundice, which is the yellowing of the skin and the whites of the eyes. This symptom is due to an accumulation of conjugated bilirubin in the bloodstream. However, individuals with DJS may experience a range of symptoms, including:
- Mild to moderate jaundice, which may fluctuate over time
- Dark-colored urine
- General fatigue and weakness
- Upper abdominal discomfort
- Enlargement of the liver (hepatomegaly), although this is usually not accompanied by significant liver dysfunction
It is important to note that many individuals with DJS may not exhibit significant clinical symptoms beyond jaundice, and the condition does not typically lead to serious liver damage. However, during periods of illness, stress, pregnancy, or alcohol consumption, symptoms may become more pronounced.
The ABCC2 Gene Dubin-Johnson Syndrome Genetic Test
DNA Labs UAE offers the ABCC2 Gene Dubin-Johnson Syndrome Genetic Test, a specialized analysis designed to detect mutations in the ABCC2 gene. This test is essential for a definitive diagnosis of DJS, helping healthcare providers to distinguish it from other forms of jaundice and liver disorders. The genetic test involves a simple blood draw or cheek swab, making it a non-invasive procedure.
The process of testing includes collecting a DNA sample from the patient, which is then analyzed in the laboratory for the presence of the specific mutation associated with DJS. The results of this test can provide crucial information for the management of the condition, including lifestyle adjustments and monitoring strategies to mitigate the impact of the syndrome.
Cost of the Test
The cost of the ABCC2 Gene Dubin-Johnson Syndrome Genetic Test at DNA Labs UAE is 4400 AED. While the cost may seem significant, it is important to consider the value of a precise diagnosis, which can lead to improved management of the condition and a better quality of life. Health insurance may cover part or all of the cost of the test, depending on the policy.
Conclusion
Dubin-Johnson Syndrome is a rare but manageable condition with a definitive diagnosis made possible through the ABCC2 Gene Dubin-Johnson Syndrome Genetic Test. DNA Labs UAE is committed to providing accurate and reliable genetic testing services, including the test for DJS. If you or a loved one are experiencing symptoms associated with DJS, consider reaching out to DNA Labs UAE for more information and to schedule a test.
For more details on the ABCC2 Gene Dubin-Johnson Syndrome Genetic Test, please visit https://dnalabsuae.com/tests/abcc2-gene-dubin-johnson-syndrome-genetic-test/.
