Xeroderma Pigmentosum (XP) is a rare genetic disorder characterized by an extreme sensitivity to ultraviolet (UV) rays from sunlight. This condition primarily affects the skin and eyes, and in some cases, the nervous system. One of the genes associated with this condition is the ERCC5 gene, also known as Xeroderma Pigmentosum Group G. Individuals with mutations in the ERCC5 gene have a subtype of Xeroderma Pigmentosum known as XPG. DNA Labs UAE offers a comprehensive genetic test for the ERCC5 gene to help diagnose Xeroderma Pigmentosum Group G, providing essential information for management and treatment options.
Symptoms of Xeroderma Pigmentosum Group G
Xeroderma Pigmentosum Group G, caused by mutations in the ERCC5 gene, manifests through a variety of symptoms. The most notable symptom is an acute sensitivity to sunlight, leading to sunburns after only a few minutes of exposure. These burns often heal poorly and can develop into blisters or cause skin discoloration. Over time, individuals with XPG may notice an increase in freckling on sun-exposed areas of the skin during childhood. Other common symptoms include:
- Dry, scaly skin
- Pigmentation changes, such as areas of increased or decreased pigmentation
- Premature aging of the skin
- Development of numerous skin cancers at a young age
- Eye problems, such as photophobia (sensitivity to light), keratitis (inflammation of the cornea), or conjunctivitis (pink eye)
- Neurological issues in some cases, including hearing loss, poor coordination, and cognitive deficits
It’s important to note that symptoms can vary significantly from person to person, even among those with the same genetic mutation.
Importance of Genetic Testing for ERCC5 Gene Xeroderma Pigmentosum Group G
Genetic testing for mutations in the ERCC5 gene is crucial for the diagnosis of Xeroderma Pigmentosum Group G. Early diagnosis allows for the implementation of protective measures to minimize UV exposure, potentially reducing the risk of skin damage and skin cancers. Additionally, knowing one’s genetic status can inform family planning decisions, as Xeroderma Pigmentosum is inherited in an autosomal recessive manner, meaning both copies of the gene in each cell have mutations.
ERCC5 Gene Xeroderma Pigmentosum Group G Genetic Test at DNA Labs UAE
DNA Labs UAE offers a specialized genetic test for the ERCC5 gene to diagnose Xeroderma Pigmentosum Group G. The test is designed to detect mutations in the ERCC5 gene that are responsible for the condition. By providing a simple saliva or blood sample, individuals can learn if they have mutations in the ERCC5 gene that may lead to Xeroderma Pigmentosum Group G.
Test Cost
The cost of the ERCC5 gene Xeroderma Pigmentosum Group G genetic test at DNA Labs UAE is 4400 AED. This price includes the cost of the sample collection kit, analysis, and a comprehensive report detailing the findings.
Conclusion
Understanding the genetic basis of Xeroderma Pigmentosum Group G through testing of the ERCC5 gene can provide valuable information for affected individuals and their families. It allows for early intervention, informed decision-making, and personalized management of the condition. DNA Labs UAE is committed to providing accurate and reliable genetic testing services, including the ERCC5 gene test for Xeroderma Pigmentosum Group G, to help individuals understand their genetic health.
For more information about the ERCC5 gene Xeroderma Pigmentosum Group G genetic test, please visit DNA Labs UAE.
