UGT1A1 Gene Polymorphism Nucleotide 'TA' Repeats Detection Test sale cost 1290 AED
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UGT1A1 Gene Polymorphism Nucleotide ‘TA’ Repeats Detection Test Cost

Original price was: 1,430 د.إ.Current price is: 1,290 د.إ.

-10%

The UGT1A1 gene polymorphism nucleotide ‘TA’ repeats detection test is a specialized genetic assay designed to identify variations in the number of thymine-adenine (TA) repeats within the promoter region of the UGT1A1 gene. This gene plays a crucial role in the process of glucuronidation, a phase II metabolic pathway responsible for the detoxification and elimination of various endogenous and exogenous substances, including bilirubin and certain drugs. Variations in the TA repeat length, particularly the presence of additional repeats, are associated with reduced enzyme activity, which can lead to conditions such as Gilbert’s syndrome, characterized by mild jaundice, and can influence drug metabolism and toxicity.

Conducted at DNA Labs UAE, this test is essential for individuals who may be at risk of drug-related toxicity or those experiencing unexplained jaundice, as it helps in the personalized adjustment of drug dosages and in the understanding of certain medical conditions. The test, priced at 1290 AED, offers a detailed insight into the genetic makeup of the UGT1A1 gene, empowering healthcare providers with critical information for tailored treatment and management strategies.

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UGT1A1 GENE POLYMORPHISM NUCLEOTIDE ‘TA’ REPEATS DETECTION Test

Test Name: UGT1A1 GENE POLYMORPHISM NUCLEOTIDE ‘TA’ REPEATS DETECTION Test

Components: Price 1290.0 AED

Sample Condition: 4 mL (2 mL min.) whole Blood in 1 Lavender top (EDTA) tube. Ship refrigerated. DO NOT FREEZE.

Report Delivery: SampleMon / Wed by 9 am; Report 7 Working days

Method: PCR, Fragment analysis

Test type: Disorders of Liver, Pharmacogenomics

Doctor: Gastroenterologist, Oncologist

Test Department: MOLECULAR DIAGNOSTICS

Pre Test Information: No special preparation required

Test Details:

The UGT1A1 gene polymorphism detection test is a genetic test that identifies the presence of a specific variation in the UGT1A1 gene. This variation involves the repetition of a specific sequence of nucleotides, specifically ‘TA’ repeats, within the gene. The UGT1A1 gene encodes an enzyme called uridine diphosphate glucuronosyltransferase 1A1, which is involved in the metabolism and elimination of various drugs and toxins from the body.

The number of ‘TA’ repeats in the UGT1A1 gene can affect the activity of this enzyme, leading to variations in drug metabolism and response. The UGT1A1 gene polymorphism detection test typically involves analyzing a person’s DNA sample, usually obtained through a blood or saliva sample. The DNA is examined to determine the number of ‘TA’ repeats in the UGT1A1 gene.

The results of the test can help healthcare professionals predict how an individual may respond to certain medications. For example, individuals with a specific number of ‘TA’ repeats may have reduced activity of the UGT1A1 enzyme, resulting in slower metabolism of drugs that are cleared by this enzyme. This can increase the risk of adverse drug reactions and require dosage adjustments.

The UGT1A1 gene polymorphism detection test is particularly important in the context of certain medications, such as irinotecan, which is used in the treatment of various cancers. Individuals with specific UGT1A1 gene variations may be at higher risk of severe side effects from irinotecan, such as neutropenia and diarrhea. Therefore, testing for this gene polymorphism can help guide personalized treatment decisions and optimize drug safety and efficacy.

It is important to note that the UGT1A1 gene polymorphism detection test is typically ordered by a healthcare professional and should be interpreted in conjunction with other clinical information. Genetic counseling may also be recommended to help individuals understand the implications of their test results and make informed decisions about their healthcare.

Test Name UGT1A1 GENE POLYMORPHISM NUCLEOTIDE ‘TA’ REPEATS DETECTION Test
Components
Price 1290.0 AED
Sample Condition 4 mL (2 mL min.) whole Blood in 1 Lavender top (EDTA) tube. Ship refrigerated. DO NOT FREEZE.
Report Delivery SampleMon / Wed by 9 am; Report 7 Working days
Method PCR, Fragment analysis
Test type Disorders of Liver, Pharmacogenomics
Doctor Gastroenterologist, Oncologist
Test Department: MOLECULAR DIAGNOSTICS
Pre Test Information No special preparation required
Test Details

The UGT1A1 gene polymorphism detection test is a genetic test that identifies the presence of a specific variation in the UGT1A1 gene. This variation involves the repetition of a specific sequence of nucleotides, specifically ‘TA’ repeats, within the gene.

The UGT1A1 gene encodes an enzyme called uridine diphosphate glucuronosyltransferase 1A1, which is involved in the metabolism and elimination of various drugs and toxins from the body. The number of ‘TA’ repeats in the UGT1A1 gene can affect the activity of this enzyme, leading to variations in drug metabolism and response.

The UGT1A1 gene polymorphism detection test typically involves analyzing a person’s DNA sample, usually obtained through a blood or saliva sample. The DNA is examined to determine the number of ‘TA’ repeats in the UGT1A1 gene.

The results of the test can help healthcare professionals predict how an individual may respond to certain medications. For example, individuals with a specific number of ‘TA’ repeats may have reduced activity of the UGT1A1 enzyme, resulting in slower metabolism of drugs that are cleared by this enzyme. This can increase the risk of adverse drug reactions and require dosage adjustments.

The UGT1A1 gene polymorphism detection test is particularly important in the context of certain medications, such as irinotecan, which is used in the treatment of various cancers. Individuals with specific UGT1A1 gene variations may be at higher risk of severe side effects from irinotecan, such as neutropenia and diarrhea. Therefore, testing for this gene polymorphism can help guide personalized treatment decisions and optimize drug safety and efficacy.

It is important to note that the UGT1A1 gene polymorphism detection test is typically ordered by a healthcare professional and should be interpreted in conjunction with other clinical information. Genetic counseling may also be recommended to help individuals understand the implications of their test results and make informed decisions about their healthcare.

SKU: TEST-5518 Category:

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