Thiopurine Methyltransferase TPMT - *2 *3A *3B *3C Genotyping Test sale cost 1200 AED
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Thiopurine Methyltransferase TPMT – *2 *3A *3B *3C Genotyping Test

Original price was: 1,600 د.إ.Current price is: 1,200 د.إ.

-25%

The Thiopurine Methyltransferase (TPMT) *2, *3A, *3B, *3C Genotyping Test is a specialized diagnostic procedure available at DNA Labs UAE, designed to analyze specific genetic variants of the TPMT enzyme. These variants, known as *2, *3A, *3B, and *3C, significantly influence the body’s ability to metabolize thiopurine drugs, which are commonly prescribed for conditions such as leukemia, autoimmune diseases, and inflammatory bowel disease.

The TPMT enzyme plays a crucial role in determining the optimal dosage of thiopurine medications for individual patients. Variations in the TPMT gene can lead to differences in enzyme activity, affecting drug efficacy and the risk of adverse reactions. Individuals with reduced or absent TPMT activity are at a higher risk of experiencing toxic side effects when taking standard doses of thiopurine drugs.

The genotyping test offered by DNA Labs UAE provides a precise and reliable method for detecting the presence of these critical TPMT variants. By identifying patients’ TPMT genotype, healthcare providers can tailor thiopurine drug dosages to optimize therapeutic outcomes and minimize the risk of toxicity. This personalized approach to medication management enhances patient safety and treatment effectiveness.

The cost of the TPMT *2, *3A, *3B, *3C Genotyping Test at DNA Labs UAE is 1200 AED. This investment in precision medicine enables patients and their healthcare teams to make informed decisions regarding thiopurine therapy, ultimately leading to better health outcomes and improved quality of life for those affected by conditions requiring thiopurine treatment.

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Thiopurine Methyltransferase TPMT – *2 *3A *3B *3C Genotyping Test

At DNA Labs UAE, we offer the Thiopurine Methyltransferase TPMT – *2 *3A *3B *3C Genotyping Test to help determine the appropriate dosage of thiopurine drugs for individual patients. This test can be done with a doctor’s prescription and is particularly useful for those undergoing treatment for autoimmune and inflammatory conditions.

Test Details

The Thiopurine Methyltransferase (TPMT) genotyping test analyzes specific genetic variants in the TPMT gene. TPMT is an enzyme involved in the metabolism of thiopurine drugs, commonly used in the treatment of various conditions. By identifying genetic variants such as TPMT*2, TPMT*3A, TPMT*3B, and TPMT*3C, we can assess the activity of the TPMT enzyme and determine the appropriate dosage of thiopurine drugs for each patient.

TPMT*2

This variant is characterized by a single nucleotide change in the TPMT gene, resulting in reduced TPMT enzyme activity. Individuals with this variant are at an increased risk of developing severe side effects when treated with thiopurine drugs.

TPMT*3A

This variant involves a deletion of two nucleotides in the TPMT gene, leading to a non-functional TPMT enzyme. Individuals with this variant have extremely low TPMT enzyme activity and are at a very high risk of experiencing severe toxicity if treated with thiopurine drugs.

TPMT*3B

This variant is caused by a single nucleotide change in the TPMT gene, resulting in reduced TPMT enzyme activity. Individuals with this variant have a moderately decreased TPMT enzyme activity and may require lower doses of thiopurine drugs to avoid toxicity.

TPMT*3C

This variant is characterized by a single nucleotide change in the TPMT gene, leading to reduced TPMT enzyme activity. Individuals with this variant have a slightly decreased TPMT enzyme activity and may require lower doses of thiopurine drugs to minimize the risk of toxicity.

Test Components

  • EDTA Vacutainer (2ml)

Price

The cost of the Thiopurine Methyltransferase TPMT – *2 *3A *3B *3C Genotyping Test is 1200.0 AED.

Sample Condition

We require a peripheral blood sample for this test.

Report Delivery

You can expect to receive your test report within 5-7 days.

Method

We use Sanger Sequencing, a molecular genetic testing method, to perform the TPMT genotyping test.

Test Type

This is a genetics test.

Doctor

This test is recommended by gynecologists.

Test Department

This test falls under our Pre Test Information category.

Pre Test Information

Please note that a doctor’s prescription is required for Thiopurine Methyltransferase (TPMT – *2, *3A, *3B, *3C) Genotyping. However, prescriptions are not applicable for surgery and pregnancy cases or individuals planning to travel abroad.

By offering the Thiopurine Methyltransferase TPMT – *2 *3A *3B *3C Genotyping Test, DNA Labs UAE aims to provide personalized healthcare solutions and minimize the risk of severe side effects associated with thiopurine drugs. Consult with your doctor to determine if this test is right for you.

Test Name Thiopurine Methyltransferase TPMT – *2 *3A *3B *3C Genotyping Test
Components EDTA Vacutainer (2ml)
Price 1200.0 AED
Sample Condition Peripheral blood
Report Delivery 5-7 days
Method Sanger Sequencing
Test type Genetics
Doctor Gynecologist
Test Department:
Pre Test Information Thiopurine Methyltransferase (TPMT – *2, *3A, *3B, *3C) Genotyping can be done with a Doctors prescription. Prescription is not applicable for surgery and pregnancy cases or people planing to travel abroad.
Test Details

Thiopurine methyltransferase (TPMT) genotyping refers to the analysis of specific genetic variants in the TPMT gene. TPMT is an enzyme involved in the metabolism of thiopurine drugs, such as azathioprine and mercaptopurine, which are commonly used in the treatment of various autoimmune and inflammatory conditions.

There are several genetic variants in the TPMT gene that can affect the activity of the TPMT enzyme. The most common variants that are genotyped include TPMT*2, TPMT*3A, TPMT*3B, and TPMT*3C.

– TPMT*2: This variant is characterized by a single nucleotide change in the TPMT gene, resulting in reduced TPMT enzyme activity. Individuals with this variant are at an increased risk of developing severe side effects when treated with thiopurine drugs.

– TPMT*3A: This variant involves a deletion of two nucleotides in the TPMT gene, leading to a non-functional TPMT enzyme. Individuals with this variant have extremely low TPMT enzyme activity and are at a very high risk of experiencing severe toxicity if treated with thiopurine drugs.

– TPMT*3B: This variant is caused by a single nucleotide change in the TPMT gene, resulting in reduced TPMT enzyme activity. Individuals with this variant have a moderately decreased TPMT enzyme activity and may require lower doses of thiopurine drugs to avoid toxicity.

– TPMT*3C: This variant is characterized by a single nucleotide change in the TPMT gene, leading to reduced TPMT enzyme activity. Individuals with this variant have a slightly decreased TPMT enzyme activity and may require lower doses of thiopurine drugs to minimize the risk of toxicity.

Genotyping for these TPMT variants is typically done using a molecular genetic testing method, such as polymerase chain reaction (PCR) or DNA sequencing. This information can help healthcare providers determine the appropriate dosage of thiopurine drugs for individual patients, minimizing the risk of severe side effects.

SKU: TEST-5371 Category:

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