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MPZ Full-Length Gene Sequence Analysis Charcot- Maria-Tooth Disease Test

Original price was: 8,000 د.إ.Current price is: 6,000 د.إ.

-25%

The MPZ Full-Length Gene Sequence Analysis Charcot-Marie-Tooth Disease Test is a specialized genetic test offered by DNA Labs UAE, designed to diagnose and understand Charcot-Marie-Tooth (CMT) disease. This test focuses on analyzing the entire length of the MPZ gene, which is crucial as mutations in this gene are known to cause certain forms of CMT disease. The MPZ gene encodes for myelin protein zero, a critical component of the myelin sheath that insulates nerve fibers. Mutations in this gene can lead to the degeneration of peripheral nerves, resulting in the characteristic symptoms of CMT disease, such as muscle weakness and atrophy, decreased muscle tone, and sensory loss.

Given the complexity and the comprehensive nature of the analysis, the test is priced at 6000 AED. Conducting the test at DNA Labs UAE ensures that patients receive accurate and reliable results, utilizing state-of-the-art genetic sequencing technologies. This detailed genetic insight is invaluable for confirming the diagnosis of CMT, understanding the specific subtype, and guiding treatment and management strategies for affected individuals.

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MPZ Full Length Gene Sequence Analysis Charcot- Maria-Tooth Disease Test

Test Cost: AED 6000.0

Test Name

MPZ Full Length Gene Sequence Analysis Charcot- Maria-Tooth Disease Test

Components

  • Sterile container
  • Sterile Normal Saline Container
  • EDTA Vacutainer (2ml)

Price

6000.0 AED

Sample Condition

Peripheral blood/Amniotic Fluid/Chorionic villi/Cord blood

Report Delivery

3-4 weeks

Method

Sanger Sequencing

Test Type

Genetics

Doctor

Gynecologist

Test Department

Pre Test Information

MPZ Full Length Gene Sequence Analysis (Charcot- Maria-Tooth Disease) can be done with a Doctors prescription. Prescription is not applicable for surgery and pregnancy cases or people planning to travel abroad.

Test Details

Charcot-Marie-Tooth (CMT) disease is a hereditary neuropathy that affects the peripheral nerves and results in muscle weakness and atrophy, sensory loss, and foot deformities. One of the genes associated with CMT is the MPZ gene, which encodes for myelin protein zero, a major component of the myelin sheath that surrounds and insulates nerve fibers.

To analyze the full length MPZ gene sequence, genomic DNA can be extracted from a blood or tissue sample and amplified using polymerase chain reaction (PCR) with primers specific to the MPZ gene. The resulting PCR product can then be sequenced using Sanger sequencing or next-generation sequencing technologies.

Sequence analysis of the MPZ gene can identify mutations or variants that may be associated with CMT. For example, some mutations in the MPZ gene can result in the production of abnormal myelin protein zero, which can disrupt the structure and function of the myelin sheath and lead to nerve damage and CMT symptoms.

In addition to identifying disease-causing mutations, MPZ gene sequence analysis can also provide information about the inheritance pattern of CMT within a family. This can be useful for genetic counseling and family planning.

Overall, MPZ gene sequence analysis is an important tool for the diagnosis and management of CMT, as well as for understanding the genetic basis of this complex neurological disorder.

Test Name MPZ Full Length Gene Sequence Analysis Charcot- Maria-Tooth Disease Test
Components Sterile container/ Sterile Normal Saline Container/ EDTA Vacutainer (2ml)
Price 6000.0 AED
Sample Condition Peripheral blood\/Amniotic Fluid\/ Chorionic villi\/ Cord blood
Report Delivery 3-4 weeks
Method Sanger Sequencing
Test type Genetics
Doctor Gynecologist
Test Department:
Pre Test Information MPZ Full Length Gene Sequence Analysis (Charcot- Maria-Tooth Disease) can be done with a Doctors prescription. Prescription is not applicable for surgery and pregnancy cases or people planing to travel abroad.
Test Details

Charcot-Marie-Tooth (CMT) disease is a hereditary neuropathy that affects the peripheral nerves and results in muscle weakness and atrophy, sensory loss, and foot deformities. One of the genes associated with CMT is the MPZ gene, which encodes for myelin protein zero, a major component of the myelin sheath that surrounds and insulates nerve fibers.

To analyze the full length MPZ gene sequence, genomic DNA can be extracted from a blood or tissue sample and amplified using polymerase chain reaction (PCR) with primers specific to the MPZ gene. The resulting PCR product can then be sequenced using Sanger sequencing or next-generation sequencing technologies.

Sequence analysis of the MPZ gene can identify mutations or variants that may be associated with CMT. For example, some mutations in the MPZ gene can result in the production of abnormal myelin protein zero, which can disrupt the structure and function of the myelin sheath and lead to nerve damage and CMT symptoms.

In addition to identifying disease-causing mutations, MPZ gene sequence analysis can also provide information about the inheritance pattern of CMT within a family. This can be useful for genetic counseling and family planning.

Overall, MPZ gene sequence analysis is an important tool for the diagnosis and management of CMT, as well as for understanding the genetic basis of this complex neurological disorder.