MPZ Full Length Gene Sequence Analysis Charcot- Maria-Tooth Disease Test
Test Cost: AED 6000.0
Test Name
MPZ Full Length Gene Sequence Analysis Charcot- Maria-Tooth Disease Test
Components
- Sterile container
- Sterile Normal Saline Container
- EDTA Vacutainer (2ml)
Price
6000.0 AED
Sample Condition
Peripheral blood/Amniotic Fluid/Chorionic villi/Cord blood
Report Delivery
3-4 weeks
Method
Sanger Sequencing
Test Type
Genetics
Doctor
Gynecologist
Test Department
Pre Test Information
MPZ Full Length Gene Sequence Analysis (Charcot- Maria-Tooth Disease) can be done with a Doctors prescription. Prescription is not applicable for surgery and pregnancy cases or people planning to travel abroad.
Test Details
Charcot-Marie-Tooth (CMT) disease is a hereditary neuropathy that affects the peripheral nerves and results in muscle weakness and atrophy, sensory loss, and foot deformities. One of the genes associated with CMT is the MPZ gene, which encodes for myelin protein zero, a major component of the myelin sheath that surrounds and insulates nerve fibers.
To analyze the full length MPZ gene sequence, genomic DNA can be extracted from a blood or tissue sample and amplified using polymerase chain reaction (PCR) with primers specific to the MPZ gene. The resulting PCR product can then be sequenced using Sanger sequencing or next-generation sequencing technologies.
Sequence analysis of the MPZ gene can identify mutations or variants that may be associated with CMT. For example, some mutations in the MPZ gene can result in the production of abnormal myelin protein zero, which can disrupt the structure and function of the myelin sheath and lead to nerve damage and CMT symptoms.
In addition to identifying disease-causing mutations, MPZ gene sequence analysis can also provide information about the inheritance pattern of CMT within a family. This can be useful for genetic counseling and family planning.
Overall, MPZ gene sequence analysis is an important tool for the diagnosis and management of CMT, as well as for understanding the genetic basis of this complex neurological disorder.
Test Name | MPZ Full Length Gene Sequence Analysis Charcot- Maria-Tooth Disease Test |
---|---|
Components | Sterile container/ Sterile Normal Saline Container/ EDTA Vacutainer (2ml) |
Price | 6000.0 AED |
Sample Condition | Peripheral blood\/Amniotic Fluid\/ Chorionic villi\/ Cord blood |
Report Delivery | 3-4 weeks |
Method | Sanger Sequencing |
Test type | Genetics |
Doctor | Gynecologist |
Test Department: | |
Pre Test Information | MPZ Full Length Gene Sequence Analysis (Charcot- Maria-Tooth Disease) can be done with a Doctors prescription. Prescription is not applicable for surgery and pregnancy cases or people planing to travel abroad. |
Test Details | Charcot-Marie-Tooth (CMT) disease is a hereditary neuropathy that affects the peripheral nerves and results in muscle weakness and atrophy, sensory loss, and foot deformities. One of the genes associated with CMT is the MPZ gene, which encodes for myelin protein zero, a major component of the myelin sheath that surrounds and insulates nerve fibers. To analyze the full length MPZ gene sequence, genomic DNA can be extracted from a blood or tissue sample and amplified using polymerase chain reaction (PCR) with primers specific to the MPZ gene. The resulting PCR product can then be sequenced using Sanger sequencing or next-generation sequencing technologies. Sequence analysis of the MPZ gene can identify mutations or variants that may be associated with CMT. For example, some mutations in the MPZ gene can result in the production of abnormal myelin protein zero, which can disrupt the structure and function of the myelin sheath and lead to nerve damage and CMT symptoms. In addition to identifying disease-causing mutations, MPZ gene sequence analysis can also provide information about the inheritance pattern of CMT within a family. This can be useful for genetic counseling and family planning. Overall, MPZ gene sequence analysis is an important tool for the diagnosis and management of CMT, as well as for understanding the genetic basis of this complex neurological disorder. |