IMMUNOSUPPRESSANT DRUG PROFILE 3 Test
Test cost: AED 1400.0
Test Components:
- Cyclosporine
- Tacrolimus
Sample Condition: 3 mL (2 mL min.) whole blood in 1 Lavender Top (EDTA) tube. Ship refrigerated. Ideal sampling time: Just before the next dose (Trough levels). Provide date & time of sampling, dose taken & time of dosing.
Report Delivery: Sample Daily by 5 pm; Report Same day
Method: LC-MS/MS
Test type: Therapeutic Drug Monitoring
Doctor: Gastroenterologist, Nephrologist
Test Department: GENETIC
Pre Test Information: Provide date & time of sampling, dose taken & time of dosing.
Test Details
Drug Name: Tacrolimus
Drug Class: Immunosuppressant
Mechanism of Action: Tacrolimus inhibits the activation of T-lymphocytes, which are key mediators of the immune response. It binds to a protein called FK506-binding protein 12 (FKBP-12), and the complex then inhibits the enzyme calcineurin. This inhibition prevents the activation of T-cells and the subsequent release of cytokines involved in the immune response.
Indications: Tacrolimus is primarily used in the prevention of organ rejection in patients who have undergone liver, kidney, or heart transplant. It is also indicated for the treatment of certain autoimmune diseases, such as rheumatoid arthritis and psoriasis.
Dosage and Administration: Tacrolimus is available in oral and intravenous formulations. The dosage varies depending on the indication, patient’s age, and other factors. For transplant patients, the initial oral dose is usually 0.1 to 0.2 mg/kg/day, divided into two doses. The dosage may be adjusted based on therapeutic drug monitoring and individual patient response.
Adverse Effects: Common side effects of tacrolimus include tremor, headache, hypertension, and gastrointestinal disturbances such as nausea and diarrhea. Long-term use of the drug may increase the risk of developing infections, lymphoma, and skin cancer. Tacrolimus can also cause nephrotoxicity, neurotoxicity, and hepatotoxicity in some patients.
Contraindications and Precautions: Tacrolimus is contraindicated in patients with a hypersensitivity to the drug or any of its components. It should be used with caution in patients with impaired renal or hepatic function. Tacrolimus can interact with many other medications, so it is important to consider potential drug interactions before initiating therapy.
Monitoring: Therapeutic drug monitoring is essential for tacrolimus therapy to ensure that the drug levels are within the therapeutic range. Blood levels of tacrolimus should be monitored regularly, especially during the early post-transplant period. Renal function, blood pressure, and liver function should also be monitored.
Conclusion: Tacrolimus is a potent immunosuppressant drug that is commonly used in transplantation medicine. It inhibits T-cell activation and is effective in preventing organ rejection. However, it carries the risk of various adverse effects and requires close monitoring to ensure therapeutic efficacy and safety.
| Test Name | IMMUNOSUPPRESSANT DRUG PROFILE 3 Test |
|---|---|
| Components | *Cyclosporine*Tacrolimus |
| Price | 1400.0 AED |
| Sample Condition | 3 mL (2 mL min.) whole blood in 1 Lavender Top (EDTA) tube. Ship refrigerated. Ideal sampling time: Just before the next dose (Trough levels). Provide date & time of sampling, dose taken & time of dosing. |
| Report Delivery | Sample Daily by 5 pm; Report Same day |
| Method | LC-MS/MS |
| Test type | Therapeutic Drug Monitoring |
| Doctor | Gastroenterologist, Nephrologist |
| Test Department: | GENETIC |
| Pre Test Information | Provide date & time of sampling, dose taken & time of dosing. |
| Test Details |
Drug Name: Tacrolimus Drug Class: Immunosuppressant Mechanism of Action: Tacrolimus inhibits the activation of T-lymphocytes, which are key mediators of the immune response. It binds to a protein called FK506-binding protein 12 (FKBP-12), and the complex then inhibits the enzyme calcineurin. This inhibition prevents the activation of T-cells and the subsequent release of cytokines involved in the immune response. Indications: Tacrolimus is primarily used in the prevention of organ rejection in patients who have undergone liver, kidney, or heart transplant. It is also indicated for the treatment of certain autoimmune diseases, such as rheumatoid arthritis and psoriasis. Dosage and Administration: Tacrolimus is available in oral and intravenous formulations. The dosage varies depending on the indication, patient’s age, and other factors. For transplant patients, the initial oral dose is usually 0.1 to 0.2 mg/kg/day, divided into two doses. The dosage may be adjusted based on therapeutic drug monitoring and individual patient response. Adverse Effects: Common side effects of tacrolimus include tremor, headache, hypertension, and gastrointestinal disturbances such as nausea and diarrhea. Long-term use of the drug may increase the risk of developing infections, lymphoma, and skin cancer. Tacrolimus can also cause nephrotoxicity, neurotoxicity, and hepatotoxicity in some patients. Contraindications and Precautions: Tacrolimus is contraindicated in patients with a hypersensitivity to the drug or any of its components. It should be used with caution in patients with impaired renal or hepatic function. Tacrolimus can interact with many other medications, so it is important to consider potential drug interactions before initiating therapy. Monitoring: Therapeutic drug monitoring is essential for tacrolimus therapy to ensure that the drug levels are within the therapeutic range. Blood levels of tacrolimus should be monitored regularly, especially during the early post-transplant period. Renal function, blood pressure, and liver function should also be monitored. Conclusion: Tacrolimus is a potent immunosuppressant drug that is commonly used in transplantation medicine. It inhibits T-cell activation and is effective in preventing organ rejection. However, it carries the risk of various adverse effects and requires close monitoring to ensure therapeutic efficacy and safety. |
