DPD GENE MUTATIONS 5-FU TOXICITY DETECTION Test
Test Cost: AED 1870.0
Symptoms and Diagnosis
The DPD gene mutations (5-FU toxicity) detection test is a diagnostic test used to identify mutations in the DPD (dihydropyrimidine dehydrogenase) gene. These mutations can lead to an increased risk of toxicity when patients are treated with the chemotherapy drug 5-fluorouracil (5-FU).
The DPD enzyme is responsible for breaking down 5-FU in the body. Mutations in the DPD gene can result in reduced or absent enzyme activity, leading to the accumulation of toxic levels of 5-FU in the body. This can cause severe side effects, such as severe gastrointestinal toxicity, myelosuppression, and even death.
Test Details
The DPD gene mutations (5-FU toxicity) detection test typically involves obtaining a blood or tissue sample from the patient. The sample is then analyzed in a laboratory using techniques such as DNA sequencing or polymerase chain reaction (PCR) to identify any mutations in the DPD gene.
It is important to note that not all patients with DPD gene mutations will experience severe toxicity when treated with 5-FU. However, the test can provide valuable information to healthcare providers to help personalize treatment plans and improve patient safety.
Test Components and Price
- Components: DPD GENE MUTATIONS 5-FU TOXICITY DETECTION Test
- Price: AED 1870.0
Sample Condition
4 mL (2 mL min.) whole blood in 1 Lavender top (EDTA) tube. Ship refrigerated. DO NOT FREEZE.
Report Delivery
12-15 working days
Method
PCR (Polymerase Chain Reaction)
Test Type
Pharmacogenomics
Doctor
Physician
Test Department
Molecular Diagnostics
Pre Test Information
Duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory.
| Test Name | DPD GENE MUTATIONS 5-FU TOXICITY DETECTION Test |
|---|---|
| Components | |
| Price | 1870.0 AED |
| Sample Condition | 4 mL (2 mL min.) whole blood in 1 Lavender top (EDTA) tube. Ship refrigerated. DO NOT FREEZE. Duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory. |
| Report Delivery | 12-15 working days |
| Method | PCR |
| Test type | Pharmacogenomics |
| Doctor | Physician |
| Test Department: | MOLECULAR DIAGNOSTICS |
| Pre Test Information | Duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory. |
| Test Details | The DPD gene mutations (5-FU toxicity) detection test is a diagnostic test that is used to identify mutations in the DPD (dihydropyrimidine dehydrogenase) gene. These mutations can lead to an increased risk of toxicity when patients are treated with the chemotherapy drug 5-fluorouracil (5-FU). The DPD enzyme is responsible for breaking down 5-FU in the body. Mutations in the DPD gene can result in reduced or absent enzyme activity, leading to the accumulation of toxic levels of 5-FU in the body. This can cause severe side effects, such as severe gastrointestinal toxicity, myelosuppression, and even death. The DPD gene mutations (5-FU toxicity) detection test typically involves obtaining a blood or tissue sample from the patient. The sample is then analyzed in a laboratory to identify any mutations in the DPD gene. This can be done through various techniques, such as DNA sequencing or polymerase chain reaction (PCR). The results of the test can help guide treatment decisions for patients who are being considered for 5-FU chemotherapy. Patients with DPD gene mutations may require dose adjustments or alternative treatment options to minimize the risk of toxicity. It is important to note that not all patients with DPD gene mutations will experience severe toxicity when treated with 5-FU. However, the test can provide valuable information to healthcare providers to help personalize treatment plans and improve patient safety. |
