ALL FISH PANEL FISH BCRABL TELAML1 MLL E2A Test – Cost, Symptoms, Diagnosis
Welcome to the DNA Labs UAE blog, where we provide detailed information about our genetic testing services. In this blog post, we will discuss the ALL FISH PANEL FISH BCRABL TELAML1 MLL E2A Test, its cost, symptoms, diagnosis, and other important details.
Test Name: ALL FISH PANEL FISH BCRABL TELAML1 MLL E2A Test
- Components: Sodium Heparin Vacutainer (2ml)
- Price: 3200.0 AED
- Sample Condition: Bone marrow / Peripheral blood (Transport immediately)
- Report Delivery: 5-7 days
- Method: FISH
- Test type: Genetics
- Doctor: Oncology
- Test Department:
Pre Test Information
The ALL FISH PANEL FISH BCRABL TELAML1 MLL E2A Test can be done with a doctor’s prescription. However, please note that the prescription is not applicable for surgery and pregnancy cases or people planning to travel abroad.
Test Details
The ALL Fish Panel is a diagnostic test used in the field of hematology to detect specific genetic abnormalities in patients with acute lymphoblastic leukemia (ALL). It is a type of fluorescence in situ hybridization (FISH) test that focuses on four specific gene rearrangements: BCR/ABL, TEL/AML1, MLL, and E2A.
1. BCR/ABL:
This gene rearrangement is commonly found in a subtype of ALL called Philadelphia chromosome-positive ALL (Ph+ ALL). It is characterized by the fusion of the BCR gene on chromosome 22 with the ABL gene on chromosome 9. The resulting BCR/ABL fusion gene produces a protein that promotes uncontrolled cell growth and division, leading to the development of leukemia.
2. TEL/AML1:
This gene rearrangement is also known as the t(12;21) translocation. It involves the fusion of the TEL gene on chromosome 12 with the AML1 gene on chromosome 21. The TEL/AML1 fusion gene is associated with a favorable prognosis in pediatric ALL, as it is commonly found in children with precursor B-cell ALL.
3. MLL:
The MLL gene, also known as the KMT2A gene, is located on chromosome 11. Rearrangements involving the MLL gene are common in infant ALL and are associated with a poor prognosis. The MLL gene rearrangement can result in the fusion of MLL with various partner genes, leading to the production of abnormal fusion proteins that disrupt normal cellular processes.
4. E2A:
The E2A gene, also known as the TCF3 gene, is located on chromosome 19. Rearrangements involving the E2A gene are commonly found in precursor B-cell ALL. The most common fusion partner for E2A is the PBX1 gene, resulting in the formation of the E2A-PBX1 fusion gene. This fusion gene is associated with a poor prognosis in ALL.
The ALL Fish Panel is performed on bone marrow or peripheral blood samples to detect these specific gene rearrangements. The test uses fluorescent probes that bind to the target genes and produce a signal that can be visualized under a fluorescence microscope. The presence or absence of these gene rearrangements helps in determining the subtype of ALL and guiding treatment decisions.
If you suspect any symptoms related to acute lymphoblastic leukemia (ALL) or require further information about the ALL FISH PANEL FISH BCRABL TELAML1 MLL E2A Test, please consult with our oncology specialist.
| Test Name | ALL FISH PANEL FISH BCRABL TELAML1 MLL E2A Test |
|---|---|
| Components | Sodium Heparin Vacutainer (2ml) |
| Price | 3200.0 AED |
| Sample Condition | Bone marrow \/ Peripheral blood (Transport immediately) |
| Report Delivery | 5-7 days |
| Method | FISH |
| Test type | Genetics |
| Doctor | Oncology |
| Test Department: | |
| Pre Test Information | ALL FISH PANEL FISH BCR/ABL, TEL/AML1, MLL, E2A]) can be done with a Doctors prescription. Prescription is not applicable for surgery and pregnancy cases or people planing to travel abroad. |
| Test Details |
The ALL Fish Panel is a diagnostic test used in the field of hematology to detect specific genetic abnormalities in patients with acute lymphoblastic leukemia (ALL). It is a type of fluorescence in situ hybridization (FISH) test that focuses on four specific gene rearrangements: BCR/ABL, TEL/AML1, MLL, and E2A. 1. BCR/ABL: This gene rearrangement is commonly found in a subtype of ALL called Philadelphia chromosome-positive ALL (Ph+ ALL). It is characterized by the fusion of the BCR gene on chromosome 22 with the ABL gene on chromosome 9. The resulting BCR/ABL fusion gene produces a protein that promotes uncontrolled cell growth and division, leading to the development of leukemia. 2. TEL/AML1: This gene rearrangement is also known as the t(12;21) translocation. It involves the fusion of the TEL gene on chromosome 12 with the AML1 gene on chromosome 21. The TEL/AML1 fusion gene is associated with a favorable prognosis in pediatric ALL, as it is commonly found in children with precursor B-cell ALL. 3. MLL: The MLL gene, also known as the KMT2A gene, is located on chromosome 11. Rearrangements involving the MLL gene are common in infant ALL and are associated with a poor prognosis. The MLL gene rearrangement can result in the fusion of MLL with various partner genes, leading to the production of abnormal fusion proteins that disrupt normal cellular processes. 4. E2A: The E2A gene, also known as the TCF3 gene, is located on chromosome 19. Rearrangements involving the E2A gene are commonly found in precursor B-cell ALL. The most common fusion partner for E2A is the PBX1 gene, resulting in the formation of the E2A-PBX1 fusion gene. This fusion gene is associated with a poor prognosis in ALL. The ALL Fish Panel is performed on bone marrow or peripheral blood samples to detect these specific gene rearrangements. The test uses fluorescent probes that bind to the target genes and produce a signal that can be visualized under a fluorescence microscope. The presence or absence of these gene rearrangements helps in determining the subtype of ALL and guiding treatment decisions. |
