Chromosomal microarray analysis (CMA), also known as chromosomal microarray testing or array comparative genomic hybridization (aCGH), is a genetic test that detects small-scale genetic changes or imbalances in the chromosomes. It is a high-resolution technique used to identify gains or losses of genetic material, known as copy number variations (CNVs), across the entire genome. Chromosomal microarray analysis has significantly improved the detection rate for genetic conditions compared to traditional cytogenetic methods.