ALL PANEL Cytogenetics and FISH BCRABL TELAML1 MLL E2A Test
Test Cost: AED 4400.0
Symptoms and Diagnosis
The ALL PANEL Cytogenetics and FISH BCRABL TELAML1 MLL E2A Test is a diagnostic test that examines the chromosomes in a person’s cells for abnormalities. This test can help identify genetic conditions or diseases. It includes specific FISH tests for the detection of genetic abnormalities commonly found in Acute Lymphoblastic Leukemia (ALL).
Test Components
- Sodium Heparin Vacutainer (2ml)
Price
AED 4400.0
Sample Condition
Bone marrow / Peripheral blood (Transport immediately)
Report Delivery
5-7 days
Method
Cell Culture + FISH
Test Type
Genetics
Doctor
Gynecologist
Test Department
Pre Test Information
ALL PANEL (Cytogenetics + FISH BCR/ABL, TEL/AML1, MLL, E2A) can be done with a doctor’s prescription. Prescription is not applicable for surgery and pregnancy cases or people planning to travel abroad.
Test Details
A cytogenetics panel is a diagnostic test that examines the chromosomes in a person’s cells for abnormalities. The FISH (Fluorescence In Situ Hybridization) technique is a specific type of cytogenetic test that uses fluorescent probes to detect and locate the presence or absence of specific DNA sequences on chromosomes.
The ALL panel, which stands for Acute Lymphoblastic Leukemia panel, includes specific FISH tests for the detection of genetic abnormalities commonly found in this type of leukemia. These abnormalities include:
- BCR/ABL: This FISH test detects the fusion of the BCR (breakpoint cluster region) gene on chromosome 22 with the ABL (Abelson) gene on chromosome 9. This fusion is characteristic of a specific subtype of ALL called Philadelphia chromosome-positive ALL (Ph+ ALL).
- TEL/AML1: This FISH test detects the fusion of the TEL (ETV6) gene on chromosome 12 with the AML1 (RUNX1) gene on chromosome 21. This fusion is commonly found in pediatric cases of ALL and is associated with a favorable prognosis.
- MLL: This FISH test detects rearrangements involving the MLL (Mixed Lineage Leukemia) gene on chromosome 11. MLL rearrangements are associated with a poor prognosis in ALL and are more commonly found in infants and young children.
- E2A: This FISH test detects rearrangements involving the E2A (TCF3) gene on chromosome 19. E2A rearrangements are found in a subset of ALL cases and can be associated with a variable prognosis.
By performing these FISH tests as part of the ALL panel, healthcare providers can identify specific genetic abnormalities that may influence the prognosis and treatment approach for individuals with acute lymphoblastic leukemia.
Test Name | ALL PANEL Cytogenetics and FISH BCRABL TELAML1 MLL E2A Test |
---|---|
Components | Sodium Heparin Vacutainer (2ml) |
Price | 4400.0 AED |
Sample Condition | Bone marrow \/ Peripheral blood (Transport immediately) |
Report Delivery | 5-7 days |
Method | Cell Culture + FISH |
Test type | Genetics |
Doctor | Gynecologist |
Test Department: | |
Pre Test Information | ALL PANEL (Cytogenetics + FISH BCR/ABL, TEL/AML1, MLL, E2A]) can be done with a Doctors prescription. Prescription is not applicable for surgery and pregnancy cases or people planing to travel abroad. |
Test Details | A cytogenetics panel is a diagnostic test that examines the chromosomes in a person’s cells for abnormalities. This can help identify genetic conditions or diseases. The FISH (Fluorescence In Situ Hybridization) technique is a specific type of cytogenetic test that uses fluorescent probes to detect and locate the presence or absence of specific DNA sequences on chromosomes. The ALL panel, which stands for Acute Lymphoblastic Leukemia panel, includes specific FISH tests for the detection of genetic abnormalities commonly found in this type of leukemia. These abnormalities include: 1. BCR/ABL: This FISH test detects the fusion of the BCR (breakpoint cluster region) gene on chromosome 22 with the ABL (Abelson) gene on chromosome 9. This fusion is characteristic of a specific subtype of ALL called Philadelphia chromosome-positive ALL (Ph+ ALL). 2. TEL/AML1: This FISH test detects the fusion of the TEL (ETV6) gene on chromosome 12 with the AML1 (RUNX1) gene on chromosome 21. This fusion is commonly found in pediatric cases of ALL and is associated with a favorable prognosis. 3. MLL: This FISH test detects rearrangements involving the MLL (Mixed Lineage Leukemia) gene on chromosome 11. MLL rearrangements are associated with a poor prognosis in ALL and are more commonly found in infants and young children. 4. E2A: This FISH test detects rearrangements involving the E2A (TCF3) gene on chromosome 19. E2A rearrangements are found in a subset of ALL cases and can be associated with a variable prognosis. By performing these FISH tests as part of the ALL panel, healthcare providers can identify specific genetic abnormalities that may influence the prognosis and treatment approach for individuals with acute lymphoblastic leukemia. |