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ALL PANEL Cytogenetics and FISH BCR-ABL TEL-AML1 MLL E2A Test

4,400 د.إ

-21%

The “All Panel Cytogenetics and FISH BCR-ABL TEL-AML1 MLL E2A Test” is a comprehensive diagnostic examination conducted at DNA Labs UAE, designed to detect chromosomal abnormalities and specific genetic mutations that are often associated with various types of leukemia and other hematologic disorders. This test employs both Cytogenetics and Fluorescence In Situ Hybridization (FISH) techniques to identify the presence of genetic alterations such as the BCR-ABL fusion gene, TEL-AML1 (ETV6-RUNX1) translocation, MLL (KMT2A) rearrangements, and E2A (TCF3) translocations. These genetic markers are critical for diagnosing conditions like Chronic Myeloid Leukemia (CML), Acute Lymphoblastic Leukemia (ALL), and other related blood cancers. The identification of these specific genetic abnormalities aids in determining prognosis, guiding treatment decisions, and monitoring response to therapy. The test is priced at 4400 AED, reflecting the comprehensive and sophisticated nature of the analysis conducted by DNA Labs UAE, a facility known for its advanced diagnostic capabilities and expertise in genetic testing.

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ALL PANEL Cytogenetics and FISH BCRABL TELAML1 MLL E2A Test

Test Cost: AED 4400.0

Symptoms and Diagnosis

The ALL PANEL Cytogenetics and FISH BCRABL TELAML1 MLL E2A Test is a diagnostic test that examines the chromosomes in a person’s cells for abnormalities. This test can help identify genetic conditions or diseases. It includes specific FISH tests for the detection of genetic abnormalities commonly found in Acute Lymphoblastic Leukemia (ALL).

Test Components

  • Sodium Heparin Vacutainer (2ml)

Price

AED 4400.0

Sample Condition

Bone marrow / Peripheral blood (Transport immediately)

Report Delivery

5-7 days

Method

Cell Culture + FISH

Test Type

Genetics

Doctor

Gynecologist

Test Department

Pre Test Information

ALL PANEL (Cytogenetics + FISH BCR/ABL, TEL/AML1, MLL, E2A) can be done with a doctor’s prescription. Prescription is not applicable for surgery and pregnancy cases or people planning to travel abroad.

Test Details

A cytogenetics panel is a diagnostic test that examines the chromosomes in a person’s cells for abnormalities. The FISH (Fluorescence In Situ Hybridization) technique is a specific type of cytogenetic test that uses fluorescent probes to detect and locate the presence or absence of specific DNA sequences on chromosomes.

The ALL panel, which stands for Acute Lymphoblastic Leukemia panel, includes specific FISH tests for the detection of genetic abnormalities commonly found in this type of leukemia. These abnormalities include:

  1. BCR/ABL: This FISH test detects the fusion of the BCR (breakpoint cluster region) gene on chromosome 22 with the ABL (Abelson) gene on chromosome 9. This fusion is characteristic of a specific subtype of ALL called Philadelphia chromosome-positive ALL (Ph+ ALL).
  2. TEL/AML1: This FISH test detects the fusion of the TEL (ETV6) gene on chromosome 12 with the AML1 (RUNX1) gene on chromosome 21. This fusion is commonly found in pediatric cases of ALL and is associated with a favorable prognosis.
  3. MLL: This FISH test detects rearrangements involving the MLL (Mixed Lineage Leukemia) gene on chromosome 11. MLL rearrangements are associated with a poor prognosis in ALL and are more commonly found in infants and young children.
  4. E2A: This FISH test detects rearrangements involving the E2A (TCF3) gene on chromosome 19. E2A rearrangements are found in a subset of ALL cases and can be associated with a variable prognosis.

By performing these FISH tests as part of the ALL panel, healthcare providers can identify specific genetic abnormalities that may influence the prognosis and treatment approach for individuals with acute lymphoblastic leukemia.

Test Name ALL PANEL Cytogenetics and FISH BCRABL TELAML1 MLL E2A Test
Components Sodium Heparin Vacutainer (2ml)
Price 4400.0 AED
Sample Condition Bone marrow \/ Peripheral blood (Transport immediately)
Report Delivery 5-7 days
Method Cell Culture + FISH
Test type Genetics
Doctor Gynecologist
Test Department:
Pre Test Information ALL PANEL (Cytogenetics + FISH BCR/ABL, TEL/AML1, MLL, E2A]) can be done with a Doctors prescription. Prescription is not applicable for surgery and pregnancy cases or people planing to travel abroad.
Test Details

A cytogenetics panel is a diagnostic test that examines the chromosomes in a person’s cells for abnormalities. This can help identify genetic conditions or diseases. The FISH (Fluorescence In Situ Hybridization) technique is a specific type of cytogenetic test that uses fluorescent probes to detect and locate the presence or absence of specific DNA sequences on chromosomes.

The ALL panel, which stands for Acute Lymphoblastic Leukemia panel, includes specific FISH tests for the detection of genetic abnormalities commonly found in this type of leukemia. These abnormalities include:

1. BCR/ABL: This FISH test detects the fusion of the BCR (breakpoint cluster region) gene on chromosome 22 with the ABL (Abelson) gene on chromosome 9. This fusion is characteristic of a specific subtype of ALL called Philadelphia chromosome-positive ALL (Ph+ ALL).

2. TEL/AML1: This FISH test detects the fusion of the TEL (ETV6) gene on chromosome 12 with the AML1 (RUNX1) gene on chromosome 21. This fusion is commonly found in pediatric cases of ALL and is associated with a favorable prognosis.

3. MLL: This FISH test detects rearrangements involving the MLL (Mixed Lineage Leukemia) gene on chromosome 11. MLL rearrangements are associated with a poor prognosis in ALL and are more commonly found in infants and young children.

4. E2A: This FISH test detects rearrangements involving the E2A (TCF3) gene on chromosome 19. E2A rearrangements are found in a subset of ALL cases and can be associated with a variable prognosis.

By performing these FISH tests as part of the ALL panel, healthcare providers can identify specific genetic abnormalities that may influence the prognosis and treatment approach for individuals with acute lymphoblastic leukemia.