ALL PANEL Cytogenetics and FISH BCRABL TEL-AML1 MLL E2A Test Price 4400 AED
Symptoms and Diagnosis
The ALL PANEL Cytogenetics and FISH BCRABL TELAML1 MLL E2A Test is a diagnostic test that examines the chromosomes in a person’s cells for abnormalities. This test can help identify genetic conditions or diseases. It includes specific FISH tests for the detection of genetic abnormalities commonly found in Acute Lymphoblastic Leukemia (ALL).
An Insight into the ALL PANEL Cytogenetics and FISH Test in the UAE
Acute Lymphoblastic Leukemia (ALL) is a form of blood cancer that predominantly impacts children, although adults can also be affected. If you or a loved one has been diagnosed with ALL in the UAE, the ALL PANEL Cytogenetics and FISH BCR-ABL TEL-AML1 MLL E2A Test can be an essential instrument for your doctor to identify the specific variant of ALL and steer treatment choices.
Comprehending Blood Cancers and ALL:
Blood comprises various cell types, including lymphocytes, which are integral to the immune system. In ALL, the bone marrow (the production center for blood cells) begins to generate abnormal, immature lymphocytes. These irregular cells displace healthy blood cells, resulting in symptoms such as exhaustion, infections, and easy bruising.
What Constitutes the ALL PANEL Cytogenetics and FISH Test?
This test amalgamates two methodologies to scrutinize the genetic composition of your leukemia cells:
Cytogenetics: This method inspects the chromosomes in your leukemia cells for irregularities like rearrangements or additional copies.
FISH (Fluorescence In Situ Hybridization): This method employs fluorescent probes to target specific genes implicated in ALL progression. The ALL PANEL FISH segment of the test concentrates on five distinct genetic abnormalities:
BCR-ABL: This is a prevalent translocation (rearrangement) observed in ALL, correlated with a specific leukemia variant. TEL-AML1: This translocation is also linked with a particular subtype of ALL. MLL: This gene rearrangement is associated with a more aggressive variant of ALL. E2A: This rearrangement can transpire in diverse types of ALL.
Advantages of the ALL PANEL Cytogenetics and FISH Test:
Precise Diagnosis: The test outcomes assist in identifying the specific genetic subtype of your ALL, leading to a more accurate diagnosis. Risk Classification: Recognizing the genetic subtype enables doctors to evaluate your overall risk of recurrence (cancer reappearing) and steer treatment decisions. Targeted Therapy: Certain genetic subtypes may respond more favorably to specific treatments. The test outcomes can aid in customizing your treatment plan for optimal results. Enhanced Prognosis: Comprehending the specific genetic structure of your ALL can assist in forecasting your overall prognosis and treatment response.
Who Can Gain from the ALL PANEL Cytogenetics and FISH Test?
This test is generally recommended for all individuals newly diagnosed with ALL, especially children.
What to Anticipate During the Test?
The ALL PANEL Cytogenetics and FISH Test typically involves a bone marrow aspiration or biopsy to gather a sample of your bone marrow cells. The sample is then dispatched to a specialized laboratory for examination. Results may take a few weeks.
Collaborating for Effective Treatment
If you’ve been diagnosed with ALL, the ALL PANEL Cytogenetics and FISH Test plays a critical role in your doctor’s capacity to determine the most suitable treatment course. By understanding the specific genetic structure of your leukemia, your doctor can devise a personalized treatment plan aimed at maximizing your chances of successful recovery.
Test Details
A cytogenetics panel is a diagnostic test that examines the chromosomes in a person’s cells for abnormalities. The FISH (Fluorescence In Situ Hybridization) technique is a specific type of cytogenetic test that uses fluorescent probes to detect and locate the presence or absence of specific DNA sequences on chromosomes.
The ALL panel, which stands for Acute Lymphoblastic Leukemia panel, includes specific FISH tests for the detection of genetic abnormalities commonly found in this type of leukemia. These abnormalities include:
- BCR/ABL: This FISH test detects the fusion of the BCR (breakpoint cluster region) gene on chromosome 22 with the ABL (Abelson) gene on chromosome 9. This fusion is characteristic of a specific subtype of ALL called Philadelphia chromosome-positive ALL (Ph+ ALL).
- TEL/AML1: This FISH test detects the fusion of the TEL (ETV6) gene on chromosome 12 with the AML1 (RUNX1) gene on chromosome 21. This fusion is commonly found in pediatric cases of ALL and is associated with a favorable prognosis.
- MLL: This FISH test detects rearrangements involving the MLL (Mixed Lineage Leukemia) gene on chromosome 11. MLL rearrangements are associated with a poor prognosis in ALL and are more commonly found in infants and young children.
- E2A: This FISH test detects rearrangements involving the E2A (TCF3) gene on chromosome 19. E2A rearrangements are found in a subset of ALL cases and can be associated with a variable prognosis.
By performing these FISH tests as part of the ALL panel, healthcare providers can identify specific genetic abnormalities that may influence the prognosis and treatment approach for individuals with acute lymphoblastic leukemia.
Test Components
- Sodium Heparin Vacutainer (2ml)
Price
4400.0 AED
Sample Condition
Bone marrow / Peripheral blood (Transport immediately)
Report Delivery
5-7 days
Method
Cell Culture + FISH
Test Type
Genetics
Doctor
Gynecologist
Test Department
Pre Test Information
ALL PANEL (Cytogenetics + FISH BCR/ABL, TEL/AML1, MLL, E2A) can be done with a doctor’s prescription. Prescription is not applicable for surgery and pregnancy cases or people planning to travel abroad.
| Test Name | ALL PANEL Cytogenetics and FISH BCRABL TELAML1 MLL E2A Test |
|---|---|
| Components | Sodium Heparin Vacutainer (2ml) |
| Price | 4400.0 AED |
| Sample Condition | Bone marrow \/ Peripheral blood (Transport immediately) |
| Report Delivery | 5-7 days |
| Method | Cell Culture + FISH |
| Test type | Genetics |
| Doctor | Gynecologist |
| Test Department: | |
| Pre Test Information | ALL PANEL (Cytogenetics + FISH BCR/ABL, TEL/AML1, MLL, E2A]) can be done with a Doctors prescription. Prescription is not applicable for surgery and pregnancy cases or people planing to travel abroad. |
| Test Details | A cytogenetics panel is a diagnostic test that examines the chromosomes in a person’s cells for abnormalities. This can help identify genetic conditions or diseases. The FISH (Fluorescence In Situ Hybridization) technique is a specific type of cytogenetic test that uses fluorescent probes to detect and locate the presence or absence of specific DNA sequences on chromosomes. The ALL panel, which stands for Acute Lymphoblastic Leukemia panel, includes specific FISH tests for the detection of genetic abnormalities commonly found in this type of leukemia. These abnormalities include: 1. BCR/ABL: This FISH test detects the fusion of the BCR (breakpoint cluster region) gene on chromosome 22 with the ABL (Abelson) gene on chromosome 9. This fusion is characteristic of a specific subtype of ALL called Philadelphia chromosome-positive ALL (Ph+ ALL). 2. TEL/AML1: This FISH test detects the fusion of the TEL (ETV6) gene on chromosome 12 with the AML1 (RUNX1) gene on chromosome 21. This fusion is commonly found in pediatric cases of ALL and is associated with a favorable prognosis. 3. MLL: This FISH test detects rearrangements involving the MLL (Mixed Lineage Leukemia) gene on chromosome 11. MLL rearrangements are associated with a poor prognosis in ALL and are more commonly found in infants and young children. 4. E2A: This FISH test detects rearrangements involving the E2A (TCF3) gene on chromosome 19. E2A rearrangements are found in a subset of ALL cases and can be associated with a variable prognosis. By performing these FISH tests as part of the ALL panel, healthcare providers can identify specific genetic abnormalities that may influence the prognosis and treatment approach for individuals with acute lymphoblastic leukemia. |
