Test Price
220 AEDโ Home Collection Available
Anti-dsDNA Antibody (Crithidia IFA) Test in Dubai | 220 AED | DHA-Approved Diagnostic Service
Executive Summary & Core Metrics
This gold-standard immunofluorescence assay offers near-perfect diagnostic specificity for detecting native double-stranded DNA antibodies, essential for confirming Systemic Lupus Erythematosus and monitoring disease activity. DNA Labs UAE delivers this test with ISO 9001:2015 accredited processing, VIP mobile phlebotomy home collection (8 AM โ 11 PM), and post-test clinical guidance by a DHA-licensed General Practitioner.
- โAccuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
- โPremium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (8 AM โ 11 PM daily).
- โClinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by DHA-licensed clinicians.
- โInsurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The Anti-dsDNA Antibody Crithidia IFA Test is the gold-standard, highly specific immunofluorescence assay for detecting antibodies against native double-stranded DNA, used primarily for the diagnosis and longitudinal monitoring of Systemic Lupus Erythematosus (SLE). This method provides superior specificity compared to ELISA-based alternatives, reducing false-positive results.
| Parameter | Our Test (Crithidia IFA) | Closest Alternative (ELISA) |
|---|---|---|
| Diagnostic Specificity | ~98โ100% (Crithidia-native dsDNA) | ~85โ95% (recombinant antigen) |
| Methodology | Immunofluorescence Assay (IFA) on Crithidia luciliae | Enzyme-Linked Immunosorbent Assay (ELISA) |
| Turnaround Time | Same Day (sample by 11 AM) | 24โ72 Hours |
| Clinical Utility | SLE diagnosis, disease activity monitoring, renal flare prediction | Screening; lower specificity may yield false positives |
| Standard Code Alignment | LOINC 5130-5 (IFA) | LOINC varies (ELISA) |
Physician Insight & Safety Protocols
"The Crithidia luciliae IFA remains the unmatched confirmatory assay for anti-dsDNA antibodies. A positive result must always be correlated with clinical findings โ including malar rash, arthritis, proteinuria, and serositis โ as isolated seropositivity without symptoms does not establish an SLE diagnosis. I urge every patient to discuss their results thoroughly with their treating rheumatologist to integrate serological data with the full clinical picture."
โ Dr. Ajay Singh
DHA Registration ID: 36234132 | General Practitioner
Medication Advisory
Prescription Continuity Warning
Do not discontinue prescribed medication โ including corticosteroids, hydroxychloroquine, mycophenolate mofetil, or any immunosuppressant โ without consulting your treating physician. Abrupt cessation may trigger severe disease flares.
Safety Exclusion Criteria & Emergency Red Flags
Exclusion Criteria (Do Not Proceed)
- Active high-grade fever (>38.5ยฐC) of unknown origin โ requires emergency evaluation first.
- Current hospitalization for acute organ-threatening SLE flare.
- Severe hemolysis or icteric serum sample (may interfere with IFA interpretation).
- Patient under 18 years without guardian consent (per Federal Decree-Law No. 4 of 2016 on Medical Liability).
ER Red Flags (Seek Immediate Care)
- Sudden pleuritic chest pain with dyspnea โ possible lupus pleuritis or pulmonary embolism.
- Acute oliguria or anuria with facial/leg edema โ suspect lupus nephritis flare.
- Altered mental status or seizures โ may indicate neuropsychiatric SLE (NPSLE).
- Petechiae, purpura, or uncontrolled bleeding โ evaluate for thrombocytopenia or catastrophic APS.
Patient FAQ & Clinical Guidance
1. What is the Anti-dsDNA Crithidia IFA test, and why is it considered the gold standard for lupus diagnosis?
The Anti-dsDNA Crithidia IFA test is a highly specific immunofluorescence assay that detects antibodies binding exclusively to native double-stranded DNA on the kinetoplast of Crithidia luciliae, offering near-perfect diagnostic specificity for Systemic Lupus Erythematosus. Unlike ELISA-based methods that may cross-react with single-stranded DNA, the Crithidia substrate ensures that only true anti-dsDNA antibodies are visualized, making it indispensable for confirming SLE diagnosis and monitoring disease activity, particularly renal involvement.
2. How should I prepare for the Anti-dsDNA test, and are there any medications I need to pause?
Overnight fasting of 8 to 10 hours is preferred before blood collection to ensure optimal serum quality for the immunofluorescence assay. You must inform your physician about all current medications โ especially biotin supplements, corticosteroids, and any immunosuppressive therapy โ as certain compounds may interfere with the IFA reading; however, never discontinue any prescribed medication without explicit medical clearance from your treating doctor.
3. What does a positive Anti-dsDNA Crithidia IFA result mean, and what should I do next?
A positive Anti-dsDNA Crithidia IFA result indicates the presence of antibodies targeting native double-stranded DNA, which is strongly associated with active Systemic Lupus Erythematosus and may signal an increased risk of lupus nephritis. You should promptly schedule a comprehensive rheumatology consultation to correlate this serological finding with clinical symptoms, urinalysis for proteinuria, serum complement levels (C3/C4), and renal function tests, as treatment decisions depend on the complete clinical picture rather than serology alone.
UAE Regulatory & Data Privacy Adherence
- โ Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) โ Patient Data Confidentiality
- โ Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields โ Digital Health Records Security
- โ Federal Decree-Law No. 4 of 2016 on Medical Liability โ Informed Consent & Patient Safety
- โ DHA Facility License Number: 1143 | DNA Labs UAE | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE
Clinical & Logistical Metadata
| Test Name | Anti-dsDNA Antibody (Crithidia IFA) Test |
| Price (AED) | 220 All-Inclusive |
| Turnaround Time | Same Day (sample by 11 AM) |
| Sample Type / Matrix | Serum (1 SST tube, 2 mL minimum) |
| Methodology Used | Indirect Immunofluorescence Assay (IFA) on Crithidia luciliae |
| ICD-10-CM Code | M32.9, M32.10, Z01.89 |
| LOINC Code | 5130-5 |
| DHA Facility License & Laboratory Address | License No. 1143 | DNA Labs UAE | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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