Leucocyte Adhesion Deficiency (LAD) is a rare, genetically inherited immunodeficiency disorder that affects the immune system’s ability to fight off infections. It is characterized by the body’s inability to properly produce or utilize certain proteins necessary for white blood cells (leucocytes) to adhere to and penetrate the walls of blood vessels to reach sites of infection. This condition is categorized into two main types: LAD I and LAD II, each with its own set of symptoms, severity, and genetic causes. Understanding the symptoms of LAD I and II is crucial for early diagnosis and treatment. DNA Labs UAE offers a comprehensive test for Leucocyte Adhesion Deficiency LAD I and II, providing a critical tool for accurate diagnosis. This test is available at a cost of 940 AED. For more information, please visit DNA Labs UAE.
Symptoms of Leucocyte Adhesion Deficiency LAD I and II
Both LAD I and LAD II share some common symptoms, primarily revolving around the body’s impaired ability to combat infections. However, each type also presents unique characteristics that distinguish them from one another. It is essential to recognize these symptoms early to seek appropriate medical intervention.
Common Symptoms of LAD I and II
- Delayed separation of the umbilical cord beyond the normal time frame, often taking more than 3 weeks to fall off
- Recurrent bacterial infections that are often severe and difficult to treat, including skin infections, pneumonia, and gingivitis
- Poor wound healing, with wounds remaining open and susceptible to infection for extended periods
- Absence of pus formation in infected areas despite the presence of severe infections
Specific Symptoms of LAD I
LAD I is typically more severe than LAD II and is associated with a higher rate of mortality if not diagnosed and treated early. Symptoms specific to LAD I include:
- Severe recurrent infections starting from a very young age, including life-threatening infections such as septicemia
- Leukocytosis, which is an abnormally high level of white blood cells, as the body attempts to fight infections without the ability of these cells to effectively reach infection sites
Specific Symptoms of LAD II
LAD II, while also serious, tends to present with milder symptoms compared to LAD I. In addition to the common symptoms, LAD II is characterized by:
- A distinct form of short stature and developmental delay
- A noticeable Bombay blood phenotype, which is a rare blood group
- Intellectual disability of varying degrees
Testing for Leucocyte Adhesion Deficiency LAD I and II
Early diagnosis and treatment of LAD I and II are crucial for improving the quality of life and survival rates of affected individuals. DNA Labs UAE offers a comprehensive testing service for LAD I and II at a cost of 940 AED. This test is vital for confirming the diagnosis and facilitating the appropriate management and treatment strategies for patients with this condition.
For families with a history of LAD or those who observe symptoms indicative of LAD in their children, it is highly recommended to seek testing. Early intervention can significantly reduce the risk of severe infections and other complications associated with this disorder.
To learn more about the Leucocyte Adhesion Deficiency LAD I and II test and to schedule a test, please visit DNA Labs UAE. Our team of experts is dedicated to providing accurate diagnoses and supporting families through their journey with LAD.
