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Leucocyte Adhesion Deficiency LAD I and II Test

940 د.إ

-10%

Leucocyte Adhesion Deficiency (LAD) types I and II are rare, inherited immunodeficiency disorders characterized by the body’s inability to fight infections effectively. These conditions result from mutations affecting the adhesion process of leukocytes (white blood cells), which is crucial for the immune response against pathogens. LAD I is caused by defects in the CD18 gene, leading to impaired leukocyte adhesion and migration. LAD II, on the other hand, results from a defect in the SLC35C1 gene, affecting the fucose transporter required for proper leukocyte adhesion.

To diagnose these conditions, a specialized test is conducted, focusing on identifying the genetic mutations associated with LAD I and II. This test is crucial for early diagnosis, enabling appropriate management and treatment strategies to prevent severe infections and improve quality of life.

In the UAE, this vital test is available at DNA Labs, a leading facility equipped with advanced diagnostic technologies. The cost of the Leucocyte Adhesion Deficiency LAD I and II Test at DNA Labs UAE is 940 AED. This investment in health allows for the accurate diagnosis of LAD I and II, guiding healthcare professionals in tailoring the best care plan for affected individuals.

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LEUCOCYTE ADHESION DEFICIENCY (LAD) I and II Test

Test Name: LEUCOCYTE ADHESION DEFICIENCY (LAD) I and II Test

Components: CD11a, CD11b, CD18, CD15s

Price: 940.0 AED

Sample Condition: 3 mL (2 mL min.) whole blood in 1 Lavender Top (EDTA) tube and 3 mL (2 mL min.) whole blood in 1 Green Top (Sodium Heparin) tube. Mix thoroughly & ship immediately at 18-22°C. DO NOT REFRIGERATE OR FREEZE. Specify time of draw and date in test request form. It is mandatory to provide clinical details & CBC report.

Report Delivery: Sample Daily by 9 am; Report Next Working day

Method: Flow Cytometry

Test Type: Immunodeficiency Disorders

Doctor: Pediatrician

Test Department: FLOW CYTOMETRY

Pre Test Information: It is mandatory to provide clinical details & CBC report.

Test Details

Leukocyte Adhesion Deficiency (LAD) is a rare genetic disorder that affects the immune system. There are two types of LAD: LAD I and LAD II. Both types are characterized by a deficiency in the ability of white blood cells (leukocytes) to adhere to the blood vessel walls and migrate to sites of infection or inflammation.

To diagnose LAD, various tests can be performed:

  1. Complete Blood Count (CBC): This test measures the number of different types of blood cells, including white blood cells. LAD patients typically have low levels of neutrophils, a type of white blood cell.
  2. Flow Cytometry: This test measures the expression of adhesion molecules on the surface of white blood cells. LAD patients show reduced or absent expression of these molecules.
  3. Genetic Testing: This test involves analyzing the patient’s DNA to identify mutations in the genes responsible for LAD. LAD I is caused by mutations in the ITGB2 gene, while LAD II is caused by mutations in the SLC35C1 gene.
  4. Adhesion Assay: This test measures the ability of white blood cells to adhere to a substrate. LAD patients show impaired adhesion compared to healthy individuals.
  5. Skin Biopsy: In some cases, a skin biopsy may be performed to examine the presence and function of adhesion molecules on white blood cells.

It is important to note that these tests should be performed by a qualified healthcare professional or a specialized laboratory. Additionally, the diagnosis of LAD should be confirmed by a geneticist or an immunologist.

Test Name LEUCOCYTE ADHESION DEFICIENCY LAD I and II Test
Components *CD11a *CD11b *CD18*CD15s
Price 940.0 AED
Sample Condition 3 mL (2 mL min.) whole blood in 1 Lavender Top (EDTA) tube AND\n3 mL (2 mL min.) whole blood in 1 Green Top (Sodium Heparin) tube. \nMix thoroughly & ship immediately at 18\u0192??22?\u00f8C. DO NOT REFRIGERATE OR FREEZE. Specify time of draw and date in test request form. It is mandatory to provide clinical details& CBC report.
Report Delivery Sample Daily by 9 am; Report Next Working day
Method Flow Cytometry
Test type Immunodeficiency Disorders
Doctor Pediatrician
Test Department: FLOW CYTOMETRY
Pre Test Information It is mandatory to provide clinical details& CBC report.
Test Details

Leukocyte Adhesion Deficiency (LAD) is a rare genetic disorder that affects the immune system. There are two types of LAD: LAD I and LAD II. Both types are characterized by a deficiency in the ability of white blood cells (leukocytes) to adhere to the blood vessel walls and migrate to sites of infection or inflammation.

To diagnose LAD, various tests can be performed:

1. Complete Blood Count (CBC): This test measures the number of different types of blood cells, including white blood cells. LAD patients typically have low levels of neutrophils, a type of white blood cell.

2. Flow Cytometry: This test measures the expression of adhesion molecules on the surface of white blood cells. LAD patients show reduced or absent expression of these molecules.

3. Genetic Testing: This test involves analyzing the patient’s DNA to identify mutations in the genes responsible for LAD. LAD I is caused by mutations in the ITGB2 gene, while LAD II is caused by mutations in the SLC35C1 gene.

4. Adhesion Assay: This test measures the ability of white blood cells to adhere to a substrate. LAD patients show impaired adhesion compared to healthy individuals.

5. Skin Biopsy: In some cases, a skin biopsy may be performed to examine the presence and function of adhesion molecules on white blood cells.

It is important to note that these tests should be performed by a qualified healthcare professional or a specialized laboratory. Additionally, the diagnosis of LAD should be confirmed by a geneticist or an immunologist.