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IGVH Mutation Load Test Cost

Original price was: 2,000 د.إ.Current price is: 1,600 د.إ.

-20%

The IGVH Mutation Load Test is a sophisticated diagnostic procedure offered by DNA Labs UAE, aimed at patients with chronic lymphocytic leukemia (CLL). This test evaluates the mutational status of the immunoglobulin heavy chain variable region (IGHV) gene, which is crucial for predicting the disease’s progression and guiding treatment strategies. A high mutation load in the IGVH gene is generally associated with a more favorable prognosis and may influence the choice of therapeutic approaches. Priced at 1600 AED, this test provides vital information for clinicians to tailor treatment plans more effectively, enhancing the potential for positive outcomes in CLL patients.

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IGVH Mutation Load Test

At DNA Labs UAE, we offer the IGVH Mutation Load Test for the diagnosis and prognosis of chronic lymphocytic leukemia (CLL) and other B-cell lymphomas. This test is crucial in determining the number and type of mutations present in the variable region of the immunoglobulin heavy chain gene (IGHV), which plays a significant role in recognizing and binding to specific antigens.

Test Details

The IGVH Mutation Load Test is performed using Sanger Sequencing, a reliable method for genetic analysis. The test requires a 2ml EDTA Vacutainer and can be conducted using bone marrow or peripheral blood samples. It is important to transport the sample immediately to ensure accurate results. The cost of the test is AED 1600.0, and the report is delivered within 7-8 days.

Prognostic Marker

The IGHV mutation load serves as a prognostic marker in CLL, providing valuable information about the disease outcome and guiding treatment decisions. Patients with a high IGHV mutation load (2% difference from the germline sequence) have a more favorable prognosis, with slower disease progression and longer overall survival. On the other hand, patients with a low IGHV mutation load (<2% difference from the germline sequence) have a poorer prognosis, with more aggressive disease and shorter survival.

Test Process

The IGHV mutation load is determined through sequencing analysis of the IGHV gene in CLL cells. This analysis compares the sequence of the CLL cells to the germline sequence, which represents the unmutated form of the gene. The percentage of sequence differences between the CLL cells and the germline sequence is used to determine the mutation load.

Importance in Treatment

By assessing the IGHV mutation load, healthcare professionals can make informed decisions regarding the aggressiveness of the disease and the most suitable treatment options for CLL patients. The IGVH Mutation Load Test is an essential tool in personalized medicine, allowing for targeted therapies and improved patient outcomes.

Pre-Test Information

The IGVH Mutation Load Test can be performed with a doctor’s prescription. However, it is not applicable for surgery and pregnancy cases or individuals planning to travel abroad.

Consultation with a Gynecologist

For the IGVH Mutation Load Test and other genetic tests, it is recommended to consult with a gynecologist who specializes in genetics. They can provide personalized guidance and ensure the appropriate testing is conducted based on individual needs and medical history.

Conclusion

The IGVH Mutation Load Test offered by DNA Labs UAE is a valuable diagnostic tool for CLL and other B-cell lymphomas. By analyzing the mutations in the IGHV gene, this test provides crucial information about the disease prognosis and helps guide treatment decisions. With a high IGHV mutation load indicating a more favorable prognosis and a low mutation load indicating a poorer prognosis, this test plays a vital role in personalized medicine and improving patient outcomes.

Test Name IGVH Mutation load Test
Components EDTA Vacutainer (2ml)
Price 1600.0 AED
Sample Condition Bone marrow \/ Peripheral blood (Transport immediately)
Report Delivery 7-8 days
Method Sanger Sequencing
Test type Genetics
Doctor Gynecologist
Test Department:
Pre Test Information IGVH Mutation load can be done with a Doctors prescription. Prescription is not applicable for surgery and pregnancy cases or people planing to travel abroad.
Test Details

The IGVH mutation load refers to the number and type of mutations present in the variable region of the immunoglobulin heavy chain gene (IGHV) in B-cell lymphomas, particularly chronic lymphocytic leukemia (CLL). The IGHV gene is responsible for encoding the variable region of the B-cell receptor, which is crucial for recognizing and binding to specific antigens.

In CLL, the IGHV mutation load is an important prognostic marker that can help predict the disease outcome and guide treatment decisions. CLL patients with a high IGHV mutation load (2% difference from germline sequence) have a more favorable prognosis, with slower disease progression and longer overall survival. On the other hand, CLL patients with a low IGHV mutation load (<2% difference from germline sequence) have a poorer prognosis, with more aggressive disease and shorter survival.

The IGHV mutation load is determined through sequencing analysis of the IGHV gene in CLL cells. This analysis compares the sequence of the CLL cells to the germline sequence, which represents the unmutated form of the gene. The percentage of sequence differences between the CLL cells and the germline sequence is used to determine the mutation load.

Overall, the IGHV mutation load is a valuable biomarker in CLL that provides important information about the aggressiveness of the disease and helps guide treatment decisions.

SKU: TEST-5146 Category:

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