NUDT15 Gene Mutation Analysis Test
At DNA Labs UAE, we offer the NUDT15 gene Mutation Analysis Test to help identify specific mutations in the NUDT15 gene that may be present in an individual. This test is important for personalized treatment decisions, especially for patients receiving thiopurine drugs.
Test Details
The NUDT15 gene is responsible for encoding an enzyme called nucleoside diphosphate linked moiety X-type motif 15, which plays a crucial role in the metabolism of thiopurine drugs. Thiopurine drugs are commonly used in the treatment of various diseases, such as leukemia, inflammatory bowel disease, and autoimmune disorders.
Mutations in the NUDT15 gene can lead to altered function of the enzyme, resulting in reduced drug metabolism and increased drug toxicity. Some specific mutations in the NUDT15 gene have been associated with a higher risk of severe side effects, including myelosuppression (reduced blood cell production) and hepatotoxicity (liver damage), when patients are treated with thiopurine drugs.
The NUDT15 gene Mutation Analysis Test involves sequencing the gene to identify any variations or changes in the DNA sequence. We use Sanger Sequencing, a reliable method for this purpose. The test can be performed using a peripheral blood sample collected in an EDTA Vacutainer (2ml).
Test Cost and Report Delivery
The cost of the NUDT15 gene Mutation Analysis Test is 1500.0 AED. The test report will be delivered within 7-8 days.
Pre Test Information
NUDT15 gene Mutation Analysis Test can be done with a doctor’s prescription. However, please note that the prescription is not applicable for surgery and pregnancy cases or people planning to travel abroad.
Who Should Consider the Test?
Genetic testing for NUDT15 gene mutations may be recommended for individuals with a family history of thiopurine-related toxicity or in populations with a higher prevalence of these mutations, such as individuals of East Asian descent.
Conclusion
The NUDT15 gene Mutation Analysis Test offered at DNA Labs UAE is a valuable tool for identifying specific mutations in the NUDT15 gene. This information can help guide personalized treatment decisions, minimize the risk of severe side effects, and improve patient outcomes.
For more information or to schedule a test, please consult with a Gynecologist or visit our Test Department.
| Test Name | NUDT15 gene Mutation Analysis Test |
|---|---|
| Components | EDTA Vacutainer (2ml) |
| Price | 1500.0 AED |
| Sample Condition | Peripheral blood |
| Report Delivery | 7-8 days |
| Method | Sanger Sequencing |
| Test type | Genetics |
| Doctor | Gynecologist |
| Test Department: | |
| Pre Test Information | NUDT15 gene Mutation Analysis can be done with a Doctors prescription. Prescription is not applicable for surgery and pregnancy cases or people planing to travel abroad. |
| Test Details | The NUDT15 gene is responsible for encoding an enzyme called nucleoside diphosphate linked moiety X-type motif 15, which is involved in the metabolism of thiopurine drugs. Thiopurine drugs are commonly used in the treatment of various diseases, including leukemia, inflammatory bowel disease, and autoimmune disorders. Mutations in the NUDT15 gene can lead to altered function of the enzyme, resulting in reduced drug metabolism and increased drug toxicity. Specifically, certain mutations in the NUDT15 gene have been associated with increased risk of severe side effects, such as myelosuppression (reduced blood cell production) and hepatotoxicity (liver damage), when patients are treated with thiopurine drugs. Mutation analysis of the NUDT15 gene can be performed to identify specific mutations that may be present in an individual. This analysis typically involves sequencing the gene to identify any variations or changes in the DNA sequence. Different techniques, such as Sanger sequencing or next-generation sequencing, can be used for this purpose. The results of NUDT15 gene mutation analysis can help guide personalized treatment decisions for patients receiving thiopurine drugs. For individuals with identified mutations, alternative treatment options or adjusted drug dosages may be considered to minimize the risk of severe side effects. Additionally, genetic testing for NUDT15 gene mutations may be recommended for individuals with a family history of thiopurine-related toxicity or in populations with a higher prevalence of these mutations, such as individuals of East Asian descent. |
